A5020695044- Melanoma and MAPK Pathways
- Cellular Mechanics and Interactions
- Polyamine Metabolism and Applications
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- melanin and skin pigmentation
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Synthesis of Tetrazole Derivatives
- Pancreatic function and diabetes
- bioluminescence and chemiluminescence research
- Biomarkers in Disease Mechanisms
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Bacteriophages and microbial interactions
- CAR-T cell therapy research
- Heat shock proteins research
- Connexins and lens biology
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
Laboratoire de Biologie du Développement de Villefranche-sur-Mer
2022
Inserm
2018-2021
Fondation pour la Recherche Médicale
2021
La Ligue Contre le Cancer
2020
Université Côte d'Azur
2018-2020
Centre Méditerranéen de Médecine Moléculaire
2017-2019
Observatoire de la Côte d’Azur
2018
CEA Paris-Saclay
2014
Centre National de la Recherche Scientifique
2014
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2014
Abstract T-cells play a crucial role in progression of autoimmunity, including vitiligo, yet the initial steps triggering their activation and tissue damage remain unknown. Here we demonstrate increased presence type-1 innate lymphoid cells (NK ILC1)-producing interferon gamma (IFNγ) blood non-lesional skin vitiligo patients. Melanocytes patients have strong basal expression chemokine-receptor-3 (CXCR3) isoform B which is directly regulated by IFNγ. CXCR3B CXCL10 at surface cultured human...
Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers associated with therapy failure. BRAF-mutant melanomas treated BRAF MEK inhibitors almost invariably develop resistance that frequently transcriptional reprogramming de-differentiated cell state. Melanoma cells secrete their own ECM proteins, an event promoted by oncogenic inhibition. Yet, the contribution cancer cell-derived tumor mechanics to drug adaptation remains poorly...
We report the development of four novel fluorescent probes to monitor activity β-galactosidase enzyme (β-gal), in vitro and living cells. The fluorophores are based on a 6-amino-styryl-benzothiazole push-pull core display strong ICT emission. encompass motif that is connected β-d-galactopyranoside moiety through self-immolative benzyl carbamate linker (βGal-1-4). screening different enabled us access new light-up two-band ratiometric reporters. probes, βGal-1-4, exhibited an extremely fast...
Abstract Although tumorigenesis is dependent on the reprogramming of cellular metabolism, metabolic pathways engaged in formation metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma 1-alpha (PGC1α) plays a pleiotropic role control cancer cell metabolism and has been associated with good prognosis prostate cancer. Here, we show that PGC1α represses metastatic properties cells via modulation polyamine biosynthesis pathway....
In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series bioactive products identified promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines isolated from patients including ones derived tumors resistant to BRAF inhibitors. Moreover, CRO15 was able decrease viability broad range cancer types. acts by two distinct mechanisms. First activating AMPK pathway induced mitochondrial disorder. Second inhibition MELK...
The sea urchin Paracentrotus lividus has been used as a model system in biology for more than century. Over the past decades, it at center of number studies cell, developmental, ecological, toxicological, evolutionary, and aquaculture research. Due to this previous work, significant amount information is already available on development species. However, fragmented rather incomplete. Here, we propose comprehensive developmental atlas species, describing its ontogeny from fertilization...
DsrA is an Escherichia coli small noncoding RNA that acts by base pairing to some mRNAs in order control their translation and turnover. It was recently shown able self-associate a way similar DNA build nanostructures. Although functional consequence of this self-assembly vivo not yet understood, the formation such assemblage more than likely influences function. We report here for first time thermodynamic basis natural self-assembly. In particular we show assembling ribonucleic acid...
An amendment to this paper has been published and can be accessed via the original article.
<p>Legends to supplementary data</p>
<p>PGC-a regulates c-MYC and ODC1 expression</p>
<p>PGC-1a suppresses PCa cell aggressiveness and polyamine synthesis</p>
<p>The downregulation of ODC1 inhibits PCa aggressiveness in ShPGC-1a cells</p>
<p>PGC-1a, c-MYC and ODC1 expression in the Taylor database</p>
<p>Lung micrometastasis</p>
<div>Abstract<p>Although tumorigenesis is dependent on the reprogramming of cellular metabolism, metabolic pathways engaged in formation metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma 1-alpha (PGC1α) plays a pleiotropic role control cancer cell metabolism and has been associated with good prognosis prostate cancer. Here, we show that PGC1α represses metastatic properties cells via modulation polyamine...
<p>Legends to supplementary data</p>
<p>PGC-1a suppresses PCa cell aggressiveness and polyamine synthesis</p>
<p>PGC-a regulates c-MYC and ODC1 expression</p>
<p>Lung micrometastasis</p>
<p>PGC-1a, c-MYC and ODC1 expression in the Taylor database</p>
<div>Abstract<p>Although tumorigenesis is dependent on the reprogramming of cellular metabolism, metabolic pathways engaged in formation metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma 1-alpha (PGC1α) plays a pleiotropic role control cancer cell metabolism and has been associated with good prognosis prostate cancer. Here, we show that PGC1α represses metastatic properties cells via modulation polyamine...