A5037487763- Sleep and Wakefulness Research
- Sleep and related disorders
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
Semmelweis University
2018-2022
Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these promoted wakefulness inhibited rapid eye movement sleep (REMS) rodents. The interaction are also present other physiological functions, such as regulation appetite. Blockade 5-HT2C modulat effect CB1 receptor antagonist, presumably consecutive or interdependent steps. Here we investigate, whether previous blockade can affect functions...
Study objectives: a) To describe the microarchitecture of wakefulness and sleep following administrations 5 10 mg/kg AM-251 in rats. b) develop a new statistical method to follow bout-to-bout dynamics. Method: Wistar rats (n = 6) had been equipped with electroencephalography (EEG) electromyography (EMG) electrodes. Following their recovery habituation after surgery, animals were injected vehicle intraperitoneally EEG, EMG motor activity was analyzed for subsequent three hours. Results:...
Stress disorders impair sleep and quality of life; however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator; we therefore hypothesized that PrRP may be involved in the development disorders. produced by medullary A1/A2 noradrenaline (NA) cells, which transmit signals to forebrain centers, non-NA cells hypothalamic dorsomedial nucleus. We found male rats both PrRP-NA innervate melanin-concentrating hormone (MCH) producing neurons dorsolateral...
The endocannabinoid and serotonin (5-HT) systems have key roles in the regulation of several physiological functions such as motor activity food intake but also development psychiatric disorders. Here we tested hypothesis, whether blockade 2C (5-HT2C) receptors prevents reduced locomotor other behavioral effects caused by a cannabinoid 1 (CB1) receptor antagonist. As pretreatment, administered SB-242084 (1 mg/kg, ip.), 5-HT2C antagonist or vehicle (VEH) followed treatment with AM-251 (5 10...