A5014534197- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Alzheimer's disease research and treatments
- Fungal and yeast genetics research
- Invertebrate Immune Response Mechanisms
- Genetic Neurodegenerative Diseases
- Signaling Pathways in Disease
- Nerve injury and regeneration
- Insect Utilization and Effects
- Insect and Arachnid Ecology and Behavior
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Cellular transport and secretion
- Sirtuins and Resveratrol in Medicine
- Insect symbiosis and bacterial influences
- Hemiptera Insect Studies
- Bioinformatics and Genomic Networks
- Microfluidic and Bio-sensing Technologies
- Physiological and biochemical adaptations
- Toxin Mechanisms and Immunotoxins
- Endoplasmic Reticulum Stress and Disease
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Biochemical and biochemical processes
- Insect Pest Control Strategies
KU Leuven
2011-2023
Physiol (Belgium)
2021
Centre de Recherche Jean Pierre Aubert
2015
Université de Lille
2015
University of Graz
2015
BioTechMed-Graz
2015
ADx NeuroSciences
2015
Ablynx (Belgium)
2015
Inserm
2015
Catholic University of America
2006
SNCA (α-synuclein) misfolding and aggregation is strongly associated with both idiopathic familial forms of Parkinson disease (PD). Evidence suggests that has an impact on cell clearance routes protein quality control systems such as the ubiquitin-proteasome system (UPS) autophagy. Recent advances in key role autosomal recessive PARK2/PARKIN PINK1 genes mitophagy, highlighted this process a prominent new pathogenic mechanism. Nevertheless, autophagy/mitophagy pathogenesis sporadic dominant...
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, which arises from a yet elusive concurrence between genetic and environmental factors. The protein α-synuclein (αSyn), principle toxic effector in PD, has been shown to interfere with neuronal Ca2+ fluxes, arguing for an involvement deregulated homeostasis this demise. Here, we identify Golgi-resident Ca2+/Mn2+ ATPase PMR1 (plasma membrane-related Ca2+-ATPase 1) as phylogenetically conserved mediator...
The conserved protein kinase Sch9 is a central player in the nutrient-induced signaling network yeast, although only few of its direct substrates are known. We now provide evidence that controls vacuolar proton pump (V-ATPase) to maintain cellular pH homeostasis and ageing. A synthetic sick phenotype arises when deletion SCH9 combined with dysfunctional V-ATPase, lack has significant impact on cytosolic (pHc) homeostasis. physically interacts with, influences glucose-dependent...
Parkinson's disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated α-synuclein and its interaction partner, synphilin-1. While synphilin-1 to accelerate inclusion formation in mammalian cells, effect on cytotoxicity remains elusive.We expressed wild-type or R621C mutant either alone combination with yeast Saccharomyces cerevisiae monitored intracellular localization proteins well repercussions growth, oxidative stress cell death....
DFNA5 was first identified as a gene responsible for autosomal dominant deafness. Different mutations were found, but they all resulted in exon 8 skipping during splicing and premature termination of the protein. Later, it became clear that protein also has tumor suppression function can induce apoptosis. Epigenetic silencing is associated with different types cancers, including gastric colorectal cancers well breast tumors. We introduced wild-type mutant allele yeast Saccharomyces...
Unraveling the biochemical and genetic alterations that control aggregation of protein tau is crucial to understand etiology tau-related neurodegenerative disorders. We expressed wild type six clinical frontotemporal dementia with parkinsonism (FTDP) mutants human in wild-type yeast cells lacking Mds1 or Pho85, respective orthologues kinases GSK3β cdk5. compared phosphorylation levels sarkosyl-insoluble (SinT), as a measure for aggregation. The deficiency Pho85 enhanced significantly...
Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of multitude neurodegenerative diseases called tauopathies, exemplified by Alzheimer′s disease. In spite an enormous amount research performed on biology, several crucial questions concerning the mechanisms toxicity remain unanswered. this paper we will highlight some processes involved in biology pathology, focusing phosphorylation interplay with oxidative stress. addition, introduce development tau‐expressing yeast...
Abstract Synphilin-1 is a major component of Parkinson’s disease (PD) inclusion bodies implicated in PD pathogenesis. However, the machinery controlling synphilin-1 formation remains unclear. Here, we investigated using systematic genome-wide, high-content imaging based screening approach (HCI) yeast Saccharomyces cerevisiae . By combining with secondary for mutants showing significant changes on fluorescence signal intensity, filtered out hits that significantly decreased expression level...
Abstract In different parts of the world, locust swarms cause severe ecological and economic damage. However, physiological mechanisms underlying this gregarization process remain elusive. study, we present a detailed quantitative analysis two neuroparsin precursor ( Scg ‐NPP1 ‐NPP2) transcripts in brain, fat body, gut, gonads accessory glands male female, gregarious solitarious desert locusts Schistocerca gregaria ). These are generally more abundant than animals. contrast to their...
The subcellular localization of polyQ-expanded huntingtin exon1 (Httex1) modulates polyQ toxicity in models Huntington's disease. Using genome-wide screens a yeast model system, we report that the ribosome quality control (RQC) machinery, recently implicated neurodegeneration, is key determinant for nucleocytoplasmic distribution Httex1-103Q. Deletion RQC genes, LTN1 or RQC1, caused accumulation Httex1-103Q nucleus through process required CAT-tail tagging activity Rqc2 and transport via...
Insects have a highly developed innate immune system, including humoral and cellular components. The responses refer to hemocyte-mediated processes such as phagocytosis, nodulation, encapsulation. Nodulation is considered the predominant defense reaction infection in insects. Treating third instar larvae of grey flesh fly, Neobellieria bullata, with laminarin (β-1,3-glucan, typical component fungal cell walls) induced nodulation dose-dependent manner. This was initiated very soon after...