A5032605840- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Cardiac Structural Anomalies and Repair
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Airway Management and Intubation Techniques
- Pancreatitis Pathology and Treatment
- Neonatal and Maternal Infections
- Heart Failure Treatment and Management
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Musculoskeletal pain and rehabilitation
- Cardiac Ischemia and Reperfusion
- Health Policy Implementation Science
Estudios Clínicos Latinoamérica
2006-2025
Helios Salud
2021
Hospital Fernández
2005
Agbar (Spain)
2004
Hospital de Clínicas "José de San Martín"
1992-2003
Universidad Nacional de La Plata
2000-2001
Hospital Universitário Clementino Fraga Filho
2000
The University of Texas Health Science Center at San Antonio
2000
Pontificia Universidad Católica de Chile
2000
Hospital Universitario de Getafe
2000
A 1-d point-prevalence study was performed with the aim of describing characteristics conventional mechanical ventilation in intensive care units ICUs from North America, South Spain, and Portugal. The involved 412 medical-surgical 1,638 patients receiving at moment study. main outcome measures were characterization indications for initiation ventilation, artificial airways used to deliver ventilator modes settings, methods weaning. median age 61 yr, duration time 7 d. Common included acute...
Objective To determine if measurements of gastric intramucosal pH have prognostic implications regarding ICU mortality. Design Prospective comparison outcome. Setting General adult ICUs in two teaching hospitals. Patients Eighty consecutive patients age 18 to 84 yrs (mean 63.4), 50 men and 30 women, 55% the medical 45% surgical services. Methods Gastric was measured on admission again 12 hrs later. A value ≥7.35 used differentiate between normal low pH. Measurements Main Results Fifty-four...
To prospectively evaluate the performance of Clinical Pulmonary Infection Score (CPIS) and its components to identify early in hospital course ventilator-associated pneumonia (VAP) which patients are responding therapy.Prospective, multicenter, a cohort mechanically ventilated patients.The intensive care unit six hospitals located metropolitan area Buenos Aires, Argentina.Sixty-three patients, from 472 hospitalized for >72 hrs, had clinical evidence VAP bacteriologic confirmation by...
Abstract Introduction Our goal was to assess the effects of titration a norepinephrine infusion increasing levels mean arterial pressure (MAP) on sublingual microcirculation. Methods Twenty septic shock patients were prospectively studied in two teaching intensive care units. The mechanically ventilated and required maintain 65 mmHg. We measured systemic hemodynamics, oxygen transport consumption (DO 2 VO ), lactate, albumin-corrected anion gap, gastric intramucosal-arterial PCO difference...
Objective To determine whether high-dose dexamethasone increases the number of ventilator-free days (VFD) among patients with acute respiratory distress syndrome (ARDS) caused by COVID-19. Design Multicenter, randomized, open-label, clinical trial. Participants Consecutive confirmed COVID-19-related ARDS were enrolled from June 17, 2020, to March 27, 2021, in four intensive care units (ICUs) Argentina Intervention 16 mg intravenously daily for five followed 8 or 6 10 days. Main Outcome and...
Resuscitation goals for septic shock remain controversial. Despite the normalization of systemic hemodynamic variables, tissue hypoperfusion can still persist. Indeed, lactate or oxygen venous saturation may be difficult to interpret. Our hypothesis was that a gastric intramucosal pH-guided resuscitation protocol might improve outcome compared with standard approach aimed at normalizing parameters such as cardiac index (CI). The 130 septic-shock patients were randomized two different goals:...
Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular fluid management sepsis in Argentina, a low middle-income country (LMIC). Furthermore, we sought test whether the utilization dynamic tests responsiveness, as guide for after initial resuscitation with persistent or recurrent hypoperfusion, associated decreased mortality.Secondary analysis national, multicenter prospective cohort study (n = 787)...
Abstract Introduction An elevation in intramucosal–arterial P CO 2 gradient (ΔP ) could be determined either by tissue hypoxia or reduced blood flow. Our hypothesis was that hypoxic with preserved flow, ΔP should not altered. Methods In 17 anesthetized and mechanically ventilated sheep, oxygen delivery decreasing flow (ischemic hypoxia, IH) arterial saturation (hypoxic HH), no intervention made (sham). the IH group ( n = 6), lowered stepwise hemorrhage; HH hydrochloric acid instilled...
The new Sepsis-3 definitions have been scarcely assessed in low- and middle-income countries; besides, regional information of sepsis outcomes is sparse. Our objective was to evaluate definition performance Argentina.Cohort study 3-month duration beginning on July 1, 2016.Forty-nine ICUs.Consecutive patients admitted the ICU with suspected infection that triggered blood cultures antibiotic administration.None.Patients were classified as having infection, (infection + change Sequential Organ...
Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis also significant inequities. In Argentina, public hospitals serve poorest segment population, while private institutions patients with coverage. Our objective was to analyze differences mortality between hospitals, using Sepsis-3 definitions. This is a multicenter, prospective cohort study including admitted 49 Argentine ICUs...