A5059373783- EEG and Brain-Computer Interfaces
- Medicinal Plants and Neuroprotection
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Pediatric Pain Management Techniques
- High Altitude and Hypoxia
- Regulation of Appetite and Obesity
- Medicinal Plant Research
- Neural dynamics and brain function
- Pelvic floor disorders treatments
- Musculoskeletal pain and rehabilitation
- Diet and metabolism studies
- Spinal Cord Injury Research
- Menopause: Health Impacts and Treatments
- Ion channel regulation and function
- Brain Tumor Detection and Classification
- Biochemical Analysis and Sensing Techniques
University of Indonesia
2016-2025
University of Malakand
2025
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2019-2024
Innovation Cluster (Canada)
2024
Czech Academy of Sciences, Institute of Physiology
2020
King Faisal Specialist Hospital & Research Centre
2013-2018
National Research Centre
2015
Augusta University
1989-2003
Oregon Health & Science University
2002-2003
University of Occupational and Environmental Health Japan
1997-2002
Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in the mammal. We used a transgenic mouse model which POMC were labeled with enhanced green fluorescent protein to perform visualized, whole-cell patch recordings from prepubertal female hypothalamic slices. The POMC-enhanced expressed same endogenous conductances (a transient outward K+ current and hyperpolarization-activated, cation current) that have been described guinea pig neurons. In...
The function of presynaptic GABA receptors in the regulation transmitter release supraoptic nucleus (SON) magnocellular neurons was investigated by recording spontaneous postsynaptic currents from rat SON a slice preparation (150μM thick, 1.8 mm diameter) using whole‐cell patch‐clamp technique. Both EPSCs and IPSCs were TTX resistant. abolished 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX), whereas picrotoxin, suggesting that are synaptic inputs glutamatergic GABAergic neurons, respectively....
Microphthalmia is a developmental eye defect that highly variable in severity and its potential for systemic association. Despite the discovery of many disease genes microphthalmia, at least 50% patients remain undiagnosed genetically. Here, we describe cohort 147 (93 families) from our consanguineous population with various forms microphthalmia (including distinct entity posterior microphthalmos) were investigated using next‐generation sequencing multi‐gene panel (i‐panel) as well whole...
This research study explores different patterns of violations among Police and their impact on policing in Swat, Khyber Pakhtunkhwa, Pakistan. The employs qualitative methodologies, utilizing interviews observations to get a detailed narrative the police working environment. data was collected from 28 personnel scales understand issue coherently logically. field show that many deviate expected pattern hampers effective service. Among various Police, Thana culture, irregularity First...
BACKGROUND: Hypoxia inducible factor-1α (HIF-1α), nuclear factor erythroid 2-related 2 (Nrf-2), and vascular endothelial growth (VEGF), play a crucial role as neuroprotective factors. Currently, there is lack of studies examining the biomolecular responses brain to intermittent hypoxia resulting from various pressures. This study was conducted investigate physiological responses, histopathological features, cellular adaptive in brains rats that were intermittently exposed hypobaric hypoxic...
ABSTRACT Prompt identification of Hyperparathyroidism‐Jaw Tumor Syndrome (HPT‐JT) is vital, particularly for those with a family history or unusual symptoms like progressive facial changes. By employing thorough diagnostic strategy that includes biochemical tests, imaging, and genetic analysis, we can achieve early diagnosis effective intervention. In this case, the patient displayed maxillofacial tumors, hypercalcemia, increased parathyroid hormone levels. Imaging confirmed adenoma, while...
Cardiopulmonary bypass during tetralogy of Fallot corrective surgery is associated with oxidative stress, and contributes to peri-operative problems. Curcumin has been known as a potent scavenger reactive oxygen species, which enhances the activity antioxidants suppresses phosphorylation transcription factors involved in inflamation apoptosis.To evaluate effects curcumin an antioxidant by evaluating concentrations malondialdehyde glutathione, nuclear factor-kappa B, c-Jun N-terminal kinase,...
Abstract We have reported that supraoptic nucleus (SON) neurones are excited by prostaglandin E 2 (PGE ) presumably via dual postsynaptic PG receptors, FP receptors and unidentified EP presynaptic may also be involved in the excitation. In present study, to clarify receptor mechanism of PGE ‐mediated actions on SON neurones, we studied pre‐ effects four newly developed agonists selective for each 1−4 , rat using extracellular recording whole‐cell patch‐clamp techniques. The 4 agonist...
To determine the role of anthropometric measurement, menopausal symptoms and biochemical marker changes as screening methods for mild cognitive impairment (MCI) in postmenopausal women Methods: A cross-sectional study included 282 Jakarta, further classified into two groups, with without MCI. Some related variables such age, body mass index (BMI), duration menopause, vasomotor symptoms, hormone levels follicle stimulating (FSH), luteinizing hormone, leptin, estradiol, status, were assessed...
Retinal dystrophies (RDs) are hereditary blinding eye conditions that highly variable in their clinical presentation. The remarkable genetic heterogeneity characterizes RD was a major challenge establishing the molecular diagnosis these patients until recent advent of next‐generation sequencing. It remains unclear, however, what percentage autosomal recessive remain undiagnosed when all established genes sequenced. We enrolled 75 families which segregates an apparently manner. show yield...
Prostaglandins (PGs) have been implicated in the regulation of vasopressin (VP) and oxytocin (OT) release response to various stimuli. To examine site mechanism actions PGs, we studied effects PGE 2 PG‐receptor agonists on supraoptic nucleus (SON) neurones rat hypothalamic slice preparations using extracellular recording whole‐cell patch‐clamp techniques. modulated electrical activity more than 80% studied. The both phasic non‐phasic were mostly excitatory, dose‐dependent. mimicked by PG F α...
An extremely rare pellagra-like condition has been described, which was partially responsive to niacin and associated with a multisystem involvement. The proposed represent novel autosomal recessive entity but the underlying mutation remained unknown for almost three decades. objective of this study identify causal in investigate mechanism by confers clinical benefit. Autozygosity mapping exome sequencing were used mutation, comet assay on patient fibroblasts before after treatment assess...
We present a Qatari family with two children who displayed characteristic phenotype of congenital marked pain insensitivity hypohidrosis and progressive aseptic destruction joints vertebrae resembling that hereditary sensory autonomic neuropathies (HSANs). The patients, aged 10 14, remained uncertain genetic diagnosis until whole genome sequencing was pursued. Genome identified novel homozygous C65S mutation in the LIFR gene is predicted to markedly destabilize alter structure particular...
Through its ability to facilitate the absorption of serotonin into presynaptic neurons, transporter, also known as SERT, an essential component in control neurotransmission. To discover SERT possible therapeutic application, it is have a solid understanding dynamic behavior, ligand interactions, and functional consequences. Within scope this investigation, predictive simulations crucial investigate complexities gain fresh operation. We use 6AWN model describe sequence simulate behavior...
Prostaglandin E2 (PGE 2 ) has been implicated in the excitatory regulation of magnocellular neurones supraoptic nucleus (SON). We have recently reported that PGE excited SON by directly activating postsynaptic receptors (EP receptors) a subclass other than EP 1–3 , but did not affect currents (EPSCs). In present study, we examined presynaptic effects on rat measuring spontaneous inhibitory (IPSCs) slice patch‐clamp technique. inhibited IPSCs dose‐dependent and reversible manner. selectively...
Bioreactor provides a biomimetic ecosystem that is able to culture cells in physically controlled system. In general, the controlled-parameters are temperature, pH, fluid flow, nutrition etc. this study, we develop bioreactor specifically targeted neural stem cells. This could overcome some limitations of conventional technology, such as petri dish, by providing specific range observation area and uniform treatment. Moreover, microfluidic bioreactor, which small-controlled environment,...