Sirtuin 1 (SIRT1) is a nuclear deacetylase that modulates lipid metabolism and enhances mitochondrial activity. SIRT1 targets multiple transcription factors coactivators. Thyroid hormone (T(3)) stimulates the expression of hepatic genes involved in fatty acid oxidation gluconeogenesis. We reported T(3) induces for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), phosphoenolpyruvate carboxykinase (pepck). increases these via activation several factors, including...

Statin use is associated with increased calorie intake and consequent weight gain. It speculated that statin-dependent improvements in lipid profile may undermine the perceived need to follow lipid-lowering other dietary recommendations leading consequently intake. However, increases statin users also be related decreases satiety factors such as leptin, an adipocyte-derived adipokine. The objective of our study was examine direct effects statins on leptin expression. Adipocytes are main...

Primary hypothyroidism has been thought of as an inflammatory condition characterized by raised levels cytokines such C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Depression is also well known to occur in hypothyroidism. elevated cytokines. We planned study whether play important part linking these two conditions.(1) To know the prevalence depression overt due autoimmune thyroid disease. (2) correlate markers with occurrence depression. (3) effect...

Vascular dysfunction and insulin resistance (IR) are associated with obstructive sleep apnea (OSA), which is characterized by frequent episodes of nocturnal intermittent hypoxia (IH). While it recognized that the balance between vasoconstrictive (endothelin-1) vasodilatory molecules (nitric oxide, NO) determine vascular profile, molecular mechanisms contributing to IR in OSA not completely understood. Caveolin-1 a membrane protein regulates endothelial nitric oxide synthase (eNOS) activity...

This work presents automated apnea event de-tection using blood oxygen saturation (SpO2) and pulse rate (PR), conveniently recorded with a oximeter. A large, diverse cohort of patients (n=8068, age≥40 years) from the sleep heart health study dataset annotated events have been employed in this study. deep-learning model is trained to detect successive 30 s epochs performances are assessed on two independent sub-cohorts test data. The proposed algorithm showcases highest performance 90.4 %...

<b>Background:</b> Cervical cancer is the commonest malignancy among women in developing countries. Cytological screening (Pap smear) have been claimed to reduce incidence and mortality of carcinoma cervix significantly for which sensitization required through community-based approach. <b> Objectives:</b> To find out number cervical cases patients reporting a general health care camp program study prevalence perceived morbidity its confirmation. Settings:</b> Cross-sectional attending...

The conversion of pyruvate to acetyl-CoA in mitochondria is catalyzed by the dehydrogenase complex (PDC). Activity PDC inhibited phosphorylation via kinases (PDKs). Here, we examined regulation Pdk4 gene expression CCAAT/enhancer-binding protein β (C/EBPβ). C/EBPβ modulates multiple hepatic genes including those involved metabolism, development, and inflammation. We found that induced decreased activity. This transcriptional induction was mediated through two binding sites promoter....

Urinary tract infection (UTI) is the most common experienced by humans after respiratory and gastro-intestinal infections, also cause of nosocomial infections for patients admitted to hospitals indeed UTIs are frequent bacterial in women.

Akt substrate of 160 kDa (AS160) phosphorylation on Thr(642) and Ser(588) by is essential for insulin's full effect glucose transport. However, protein determined the balance actions kinases phosphatases, specific phosphatase(s) controlling AS160 dephosphorylation (are) unknown. Accordingly, we assessed roles highly expressed skeletal muscle serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C) dephosphorylation. Preliminary screening candidate used an assay. Lysates from insulin-stimulated...

BACKGROUND: There is growing recognition of the role mobile learning (M-learning) for undergraduate (UG) academic education and teaching purposes, but teacher attitudes toward it can be variable.OBJECTIVE: To determine incorporation M-learning methods UG medical among resident doctors at a government college in Delhi, India.METHODS: A cross-sectional study was conducted 3-months duration (2019) 60 final year junior senior doctors. The participants were selected from all preclinical...

It is imperative to explore the gigantic available chemical space identify new scaffolds for drug lead discovery. Identifying potent hits from virtual screening of large databases challenging and computationally demanding. Rather than traditional two-dimensional (2D)/three-dimensional (3D) approaches on smaller libraries a few hundred thousand compounds, we screened ZINC library 15 million compounds using multiple computational methods. Here, present successful application methodology that...

A traditional physicochemical descriptors-based QSAR analysis was conducted on a data-set of Endothelin-A Receptor Antagonists for the treatment Pulmonary Arterial Hypertension. variety statistical techniques, including non-linear techniques like artificial neural networks and linear analytical i.e., 'Multiple Linear Regression' 'Partial Least Squares' implicated in current research. The development models were then put through validation process leave one out, which supported their high...

Objective : To study the hematological profile of anemic pregnant women who were attending antenatal hospital.Material and Methods Pregnant had hemoglobin value < 11gm selected.Total 66 enrolled for study.. Pretested questionnaire was used to collect general information.Blood samples collected by qualified technician estimation.Results Out total participated, 11 (16%) belong age group <20, 36 (54%) 20-25 19 (30%) from > 25 years.Out 66, 28 (42%) primi gravidae, 26 (39%) multigravidae 12...

The aim of this study was to investigate the morphologic and ultrastructural features biofilms slow fast-growing mycobacteria in different stress conditions, presence absence oleic acid albumin dextrose catalase (OADC) enrichment at temperatures: 30, 37 42 °C. Four hundred mycobacterial isolates were taken. biomass each biofilm quantified using a modified microtiter plate assay method. Isolates divided into those that formed fully established biofilms, moderately attached weakly adherent by...

Typhoid has been reported to be a common and significant cause of morbidity in pre-school school-age children the endemic countries like India. The incidence typhoid as high 27.3 per 1000 person-years less than 5 years age. Serious complications occur about 10% cases requiring hospitalization. mean cost treatment episode blood culture-confirmed fever calculated INR 3,597 (1996 prices) an outdoor setting, whereas case hospitalization, illness increases by several folds (INR 18,131). Vi...