A5040254954- Anesthesia and Sedative Agents
- Pediatric Pain Management Techniques
- Anesthesia and Neurotoxicity Research
- Orthopedic Surgery and Rehabilitation
- Airway Management and Intubation Techniques
- Facial Nerve Paralysis Treatment and Research
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Infant Development and Preterm Care
- Pharmaceutical studies and practices
- Veterinary Pharmacology and Anesthesia
- Infant Health and Development
- Pediatric Urology and Nephrology Studies
- Treatment of Major Depression
- Medical Malpractice and Liability Issues
- Ear Surgery and Otitis Media
- Anesthesia and Pain Management
- Peripheral Nerve Disorders
- Analytical Methods in Pharmaceuticals
- Neonatal and fetal brain pathology
- Central Venous Catheters and Hemodialysis
- Bacterial Infections and Vaccines
- Metabolism and Genetic Disorders
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
The University of Queensland
2016-2023
Princess Margaret Hospital for Children
2022-2023
Mater Research
2016-2023
Queensland Children’s Hospital
2016-2023
The University of Western Australia
2022-2023
Royal Children's Hospital
2022
Murdoch Children's Research Institute
2022
Children's Hospital at Westmead
2022
Starship Children's Health
2007-2022
Gold Coast Hospital
2022
Summary Aim: We aimed to produce a racemic ketamine manual infusion regimen capable of maintaining steady‐state blood concentration associated with anesthesia in children aged 1.5–12 years. Method: The literature was searched for humans. Pharmacokinetic parameter estimates were taken from published studies data and used pharmacokinetic simulation program predict likely concentrations during infusions. A variability 10% allowed about the chosen target concentration. Results: 3 mg·l −1...
The aim of this study was to describe ketamine pharmacodynamics (PD) in children. Adult concentrations during recovery are reported as 0.74 mg.l(-1) (sd 0.24 mg.l(-1)) with an EC(50) for anesthesia 2 0.5 mg.l(-1)), but pediatric data few.Children presenting painful procedures Emergency Department were given 1-1.5 mg.kg(-1) i.v. Blood assayed on three six occasions (median 3) over the subsequent 14-152 min 28.5). Procedures videotaped. Level sedation (0-5; unresponsive - spontaneously awake...
Bell’s palsy or acute idiopathic lower motor neurone facial paralysis is characterized by sudden onset weakness of the muscles to one side face controlled nerve. While there high level evidence in adults demonstrating an improvement rate complete recovery nerve function when treated with steroids compared placebo, similar studies on use children are not available. The aim this study assess utility a randomised placebo-controlled trial. We conducting randomised, triple-blinded, placebo trial...
Background Paediatric distal forearm fractures are a common ED presentation. They can be diagnosed with point-of-care ultrasound (POCUS) as an alternative to X-rays. Given that nurse practitioners (NPs) relied on for the diagnosis of paediatric fractures, it is important describe diagnostic accuracy NP-conducted POCUS versus X-ray. Methods This prospective study was conducted in tertiary hospital Queensland, Australia, between February 2018 and April 2019. Participants were children aged...
Corticosteroids are used to treat the early stages of idiopathic facial paralysis (Bell palsy) in children, but their effectiveness is uncertain. We set out determine whether prednisolone improves proportion children with Bell palsy complete recovery at 1 month.We conducted a double-blind, placebo-controlled, randomized trial presenting emergency departments palsy. Patients aged 6 months younger than 18 years were recruited within 72 hours after symptom onset and randomly assigned receive 10...
The aim of this study was to describe ketamine pharmacokinetics in children simulate time-concentration profiles predict duration concentrations associated with anesthesia, arousal and analgesia.Children presenting for painful procedures the Emergency Dept were given 1-1.5 mgxkg(-1) i.v. Blood assayed on 3-6 occasions (median 3) over subsequent 14-152 min 28.5). A population pharmacokinetic analysis undertaken by using nonlinear mixed effects models (NONMEM). Simulation used cohortThere 188...
Summary Background: Norketamine, a metabolite of ketamine, is an analgesic with potency one‐third that ketamine. The aim this study was to describe norketamine pharmacokinetics in children order predict time–concentration profiles for after racemic ketamine single dose and infusion administration. possible potential resulting from concentration may then be predicted using simulation. Methods: Ketamine data were available two sources: (i) presenting procedural sedation emergency department...
Abstract Objective: To audit pain management practices and organization in paediatric ED across Australia New Zealand. Methods: Retrospective of Paediatric Research Emergency Departments International Collaborative 20 cases each migraine, abdominal femoral shaft fracture. Review organizational status at sites. Results: Of 14 ED, 10 participated the clinical audit. A total 196 197 177 femur fracture were reviewed. Less than half had degree measured or score documented on triage. Migraine...
Summary Aims: The aim of this study was to describe ketamine pharmacokinetics when administered orally children suffering from burn injury in >10% body surface area. Methods: Children ( n = 20) were given 5 or 10 mg·kg −1 20 min prior presentation for surgical procedures. Anesthesia during procedures maintained with a volatile anesthetic agent. Additional intravenous as bolus (0.5–1 ) nine the procedure while further an infusion (0.1 ·h continued 4–19 h after procedure. Blood assayed and...
Objective: To describe intravenous ketamine dosing regimens for children requiring brief procedural sedation. Methods: Time-concentration and sedation profiles were simulated in (2, 6, 12 years old) using published pediatric pharmacokinetic pharmacodynamic parameter estimates. Single-dose, repeat-dosing, infusion to achieve level of less than 2 (arouses slowly consciousness, with sustained painful stimulus) 15 minutes investigated. Results: A single bolus dose 1.5 1.75, 2, 2.125 mg/kg (for...
Voiding cystourethrography (VCU) is a distressing procedure for children. Conscious sedation using oral midazolam may reduce this distress, but its use also alter the ability of VCU to show vesicoureteric reflux (VUR). The objectives our study were assess effectiveness conscious when administered routinely in children undergoing and ensure that does not VUR.Our was randomized double-blind controlled trial performed at university teaching hospital; group consisted over age 1 year who been...
Background . Voiding cystourethrograms are distressing for children and parents. Nonpharmacological methods reduce distress. Pharmacological interventions VCUG focus on sedation as well analgesia, anxiolysis, amnesia. Sedation has cost, time, safety issues. Which agents route should we use? Are sure that does not influence the ability to diagnose vesicoureteric reflux? Methods Literature search of Medline, EMBASE, Cochrane Database. Review comparative studies found. Results Seven including...
<h3>Background:</h3> Topical anaesthetics reduce the pain of venous cannulation. The emergency department at Starship Children's Hospital in Auckland uses EMLA (an eutectic mixture 25 mg/g lidocaine and prilocaine) for topical anaesthesia. Amethocaine has recently been shown to be a more effective anaesthetic. It is suggested that, because amethocaine does not vasoconstrict veins, it may increase success <h3>Aim:</h3> primary aim was determine if improves cannulation compared with EMLA....
<h3>Background and Objectives:</h3> Bell's palsy is the third most frequent diagnosis in children with sudden onset neurological dysfunction. The cost-effectiveness of treating prednisolone unknown. We aimed to assess Palsy compared placebo. <h3>Methods:</h3> This economic evaluation was a prospectively planned secondary analysis double-blinded, randomized, placebo-controlled superiority trial (BellPIC) conducted from 2015 2020. Time horizon 6 months since randomization. Children aged <18...
An accurate and comprehensive pain assessment is crucial for adequate management in pre- early verbal children during painful medical procedures. This study used an inductive approach to explore the processes involved parental develop a new model of Parental Assessment Acute Child Pain. Participants were 19 parents aged under 3 years who had previously or potentially about experience intravenous cannula nasogastric tube insertion. affect regulation, while witnessing their child acute...
Summary Background Intravenous racemic ketamine is commonly administered for procedural sedation, although few pharmacokinetic studies have been conducted among children. Moreover, an optimal sampling schedule has not derived to enable the conduct of that minimally inconvenience study participants. Methods Concentration‐time data were obtained from 57 children who received 1–1.5 mg·kg −1 as intravenous bolus. A population analysis was using nonlinear mixed effects models, and results used...
Aim: Newborn infants are routinely exposed to pain. We wanted see how practice regarding pain relief changed over a 6‐year period. Methods: Serial audits were carried out of existing and attitudes at three points, span, in New Zealand neonatal units. Results: Almost all units agreed that many commonly performed procedures painful the study The number using analgesia rose markedly same Conclusions: fact simple, cheap effective intervention (oral sucrose) has taken more than 6 years be used...
<h3>Introduction</h3> Starship Hospital Children9s Emergency Department (CED) uses EMLA for topical anaesthesia during insertion of intravenous cannula (IVC). Amethocaine has recently been shown to offer more effective pain relief and work faster than EMLA, but may be expensive. <h3>Aim</h3> To determine cost implications introducing amethocaine into CED practice. <h3>Methods</h3> Data were obtained from a randomised controlled trial, quality assurance project an audit anaesthetic use, with...
Abstract Objective Currently there is no parent administered scale for facial nerve function in children. We set out to assess the agreement between a newly developed parent‐administered modified version of House‐Brackmann (HB) and standard clinician‐administered HB children with Bell's palsy. Study Design Secondary analysis triple‐blind, randomized, placebo‐controlled trial corticosteroids treat idiopathic paralysis (Bell's palsy) (6 months <18 years). Setting Multicenter study at...