A5073740256- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- Signaling Pathways in Disease
- Nicotinic Acetylcholine Receptors Study
- Genetic Neurodegenerative Diseases
- Biomimetic flight and propulsion mechanisms
- Nerve injury and regeneration
- Genomics and Chromatin Dynamics
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
The University of Tokyo
2020-2024
Tokyo Metropolitan University
2014-2019
Inactivation of the ubiquitin ligase Ube3a causes developmental disorder Angelman syndrome, whereas increased dosage is associated with autism spectrum disorders. Despite enriched localization in axon terminals including presynapses, little known about presynaptic function and mechanisms underlying its localization. We show that synapse elimination requires activity Drosophila neurons. further identified domain required for interaction kinesin motor. syndrome-associated missense mutations...
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon dendrite formation is still incomplete. Neurite outgrowth requires supply membrane components for surface expansion. Two sources are suggested: Golgi secretary vesicles endocytic recycling endosomes. In non-neuronal cells, trafficking from regulated by Rab8, member Rab small GTPases, that endosomes Rab11, another Rabs. whether these coordinately...
Tau is a microtubule (MT)-associated protein that regulates MT dynamics in the axons of neurons. binds to MTs via its C-terminal MT-binding repeats. There are two types tau, those with three (3R) or four (4R) repeats; 4R tau has stronger MT-stabilizing activity than 3R tau. The regulated by phosphorylation. Interestingly, both isoform and phosphorylation change at time neuronal circuit formation during postnatal development; highly phosphorylated replaced which less phosphorylated. However,...
A hallmark of Alzheimer's disease (AD) pathology is the appearance senile plaques, which are composed β-amyloid (Aβ) peptides. Aβ produced by sequential cleavages amyloid precursor protein (APP) β- and γ-secretases. These take place in endosomes during intracellular trafficking APP through endocytic recycling pathways. Genome-wide association studies have identified several risk factors for late-onset AD, one CD2-associated (CD2AP), an adaptor molecule that regulates membrane trafficking....
Cyclin-dependent kinase 5 (Cdk5) is a Ser/Thr that plays an important role in the release of neurotransmitter from pre-synaptic terminals triggered by Ca(2+) influx into cytoplasm through voltage-dependent channels (VDCCs). It reported Cdk5 regulates L-, P/Q-, or N-type VDCC, but there conflicting data as to effect on VDCC activity. To clarify mechanisms involved, we examined regulating -channel property VDCCs, using PC12 cells expressing endogenous, functional and VDCCs. The influx, induced...
ABSTRACT Drosophila serves as a highly valuable model organism across numerous fields including genetics, immunology, neuroscience, cancer biology, and developmental biology. Central to -based biological research is the ability perform comprehensive genetic or chemical screens. However, this often limited by its dependence on laborious manual handling analysis, making it prone human error difficult discern statistically significant rare events amid noise of individual variations resulting...
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon dendrite formation is still incomplete. Neurite outgrowth requires supply membrane components for surface expansion. Two sources are suggested: Golgi secretary vesicles endocytic recycling endosomes. In non-neuronal cells, trafficking from regulated by Rab8, member Rab small GTPases, that endosomes Rab11, another Rabs. whether these coordinately...