A5044835238- Veterinary Equine Medical Research
- Veterinary Pharmacology and Anesthesia
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Tendon Structure and Treatment
- Pain Mechanisms and Treatments
- Veterinary Practice and Education Studies
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Bone Tissue Engineering Materials
- Veterinary Orthopedics and Neurology
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Pediatric Pain Management Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary Medicine and Surgery
- 3D Printing in Biomedical Research
- Empathy and Medical Education
- Musculoskeletal pain and rehabilitation
- Neuropeptides and Animal Physiology
- Airway Management and Intubation Techniques
- Gastrointestinal disorders and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Coccidia and coccidiosis research
- Animal health and immunology
Utrecht University
2014-2025
Royal Veterinary College
2023-2025
University of London
2023-2024
University of Nottingham
2023
Koninklijke Nederlandse Maatschappij voor Diergeneeskunde
2008
Mammalian articular cartilage serves diverse functions, including shock absorption, force transmission and enabling low-friction joint motion. These challenging requirements are met by the tissue's thickness combined with its highly specific extracellular matrix, consisting of a glycosaminoglycan-interspersed collagen fiber network that provides unique combination resilience high compressive shear resistance. It is unknown how this critical tissue deals challenges posed increases in body...
Decellularized tissues have proven to be versatile matrices for the engineering of and organs. These usually consist collagens, matrix-specific proteins, a set largely undefined growth factors signaling molecules. Although several decellularized found their way clinical applications, use in cartilage tissue has only been explored limited extent. We out generate hydrogels from tissue-derived matrices, as are current preferred cell carriers repair. Equine cartilage, meniscus, tendon was...
Inflammation is an important feature of many joint diseases, and levels cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little known about the magnitude time course inflammation-induced changes tissue turnover as vivo markers. We aimed to study temporal concentrations mediators, matrix metalloproteinase activity over 1 week joints with experimentally induced inflammation.Localized inflammation was intercarpal six horses sterile injection 0.5 ng...
Summary Reasons for performing study : Meloxicam is a commonly used nonsteroidal anti‐inflammatory drug in equine practice, but little known about its vivo effects on joint inflammation and cartilage turnover. Objectives To the of meloxicam biomarkers inflammation, matrix metalloproteinase (MMP) activity, joints with experimental synovitis. Methods In 2‐period cross‐over study, synovitis was induced at T = 0 h L or R intercarpal 6 horses by intraarticular injection 0.5 ng lipopolysaccharide...
Intra-articular administration of morphine as a local analgesic and anti-inflammatory drug is widely used in human medicine. In equids, little known about its clinical efficacy.To use an inflammatory orthopaedic pain model to investigate the effects intra-articularly administered new treatment modality horses with acute arthritis.In crossover study design, synovitis was induced left or right talocrural joint by means intra-articular injection 0.5 ng lipopolyssacharide (LPS). The effect 120...
The clinical translation of three-dimensionally printed bioceramic scaffolds with tailored architectures holds great promise toward the regeneration bone to heal critical-size defects. Herein, long-term in vivo performance hydrogel-ceramic composites made methacrylated-oligocaprolactone-poloxamer and low-temperature self-setting calcium-phosphates is assessed a large animal model. Scaffolds different internal architectures, displaying either designed porosity gradient or constant pore...
Chronic pain is an ill-defined disease with complex biopsychosocial aspects, posing treatment challenges. We hypothesized that failure results, at least partly, from limited understanding of diverse patient subgroups. aimed to identify subgroups using psychological variables, allowing for more tailored interventions. In a retrospective cohort study, we extracted patient-reported data two Dutch tertiary multidisciplinary outpatient clinics (2018-2023) unsupervised hierarchical clustering....
Abstract Background Pain assessment based on facial expressions has been described in foals. Objectives To extend previous pilot findings of the Equine Utrecht University Scale for Facial Assessment Foals (EQUUS‐FAP FOAL). Study design Prospective blinded case–control study (known groups analysis). Methods Video recordings (30–60 s) n = 100 foals (38 patients and 62 controls) were collected. Videos randomised scored by two observers, condition animals. Inter‐ intra‐observer agreement was...
Intra-articular (IA) injection of corticosteroids with or without hyaluronate (HA) has been used for decades in equine practice treatment noninfectious synovitis and osteoarthritis. However, to date, no large-scale randomised field trials have reported that address the supposed superior clinical efficacy combination corticosteroid + HA compared IA alone.To compare triamcinolone acetonide (TA, 12 mg) TA (12 high molecular weight (20 horses joint disease.Prospective, randomised, parallel, open...
Reasons for performing the study: Joint pain is one of most common causes lameness in horse but its pathogenesis poorly understood. Objectives: To investigate which synovial fluid markers may be related to presence clinically detectable joint horse. Methods: Concentrations structural (CPII, C2C, GAG) and inflammatory (PGE2, LTB4, CysLTs, bradykinin substance P) were measured fetlock from 22 horses was localised region by perineural anaesthesia. Levels these then compared that responded (n =...
Articular tissues are capable of producing a range eicosanoid mediators, each which has individual biological effects and may be affected by anti-inflammatory treatment. We set out to develop evaluate high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) approach for the simultaneous analysis multiple lipid mediators in equine synovial fluid (SF), illustrate its use investigation vivo non-steroidal drug (NSAID) treatment.Synovial samples were obtained from normal...
Abstract Objective —To assess whether reported alterations in metabolism of cartilage matrix young (0 to 24 months old) horses with osteochondritis dissecans (OCD) may also be found older (24 48 clinical signs OCD and investigate the role eicosanoids initiating these signs. Sample Population —Synovial fluid was collected from 38 tarsocrural joints warmblood (22 16 horses) or without (16 8 a radiographic diagnosis distal intermediate ridge tibia. Procedures —Turnover type II collagen...
An owner-completed questionnaire was designed to monitor the level of chronic pain and impact on quality life in horses with osteoarthritis (OA). A standardized approach develop validate subjective-state scales for clinical use followed. Scale items were generated through literature review, focus group meetings, expert panel evaluation. The draft tool tested reading language ambiguity piloted 25 owners/caregivers osteoarthritis, factor analysis performed responses. resulting revised is...
Bone has great self-healing capacity, but above a certain critical size, bone defects will not heal spontaneously, requiring intervention to achieve full healing. Among the synthetic calcium phosphate (CaP) replacement materials, brushite (CaHPO4·2H2O)-based materials are of particular interest because their degree solubility and related high potential promote regeneration after dissolution. They can be produced tailor-made using modern three-dimensional (3D) printing technology. Although...
Adrenalectomy is the treatment of choice in case functional adrenal tumors and malignant incidentalomas. Laparoscopic adrenalectomy (LA) dogs has gained popularity recent years, however, clinical studies on large patient populations are scarce. This retrospective study describes perioperative recurrence data, survival, prognostic factors 70 that underwent LA or open (OA) our hospital between 2008 2022. Diagnosis was based history, signs, endocrine function tests advanced diagnostic imaging....