A5004629519- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Motor Control and Adaptation
- Spinal Fractures and Fixation Techniques
- Muscle activation and electromyography studies
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Bone health and osteoporosis research
- Gastric Cancer Management and Outcomes
- Musculoskeletal pain and rehabilitation
- Stroke Rehabilitation and Recovery
- Bone Metabolism and Diseases
- Medical Imaging and Analysis
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Balance, Gait, and Falls Prevention
- Lower Extremity Biomechanics and Pathologies
- Clinical Nutrition and Gastroenterology
- Meningioma and schwannoma management
- Cerebral Palsy and Movement Disorders
- Osteoarthritis Treatment and Mechanisms
Tokyo Medical and Dental University
2014-2024
Kindai University
2008-2024
Institute of Science Tokyo
2024
Okayama University
2022-2023
Tsuyama Chuo Hospital
2022-2023
Naga Municipal Hospital
2020-2023
Neurological Surgery
2023
Gifu University
2023
Cyber University
2023
The University of Tokyo
2023
Growing evidence shows that microRNAs (miRNAs) regulate various developmental and homeostatic events in vertebrates invertebrates. Osteoblast differentiation is a key step proper skeletal development acquisition of bone mass; however, the physiological role non-coding small RNAs, especially miRNAs, osteoblast remains elusive. Here, through comprehensive analysis miRNAs expression during differentiation, we show miR-206, previously viewed as muscle-specific miRNA, regulator this process....
Artificial intelligence (AI) has gained tremendous popularity recently, especially the use of natural language processing (NLP). ChatGPT is a state-of-the-art chatbot capable creating conversations using NLP. The AI in medicine can have impact on health care delivery. Although some studies evaluated ChatGPT's accuracy self-diagnosis, there no research regarding its precision and degree to which it recommends medical consultations.
Chondrocyte differentiation is strictly regulated by various transcription factors, including Runx2 and Runx3; however, the physiological role of Runx1 in chondrocyte remains unknown. To examine Runx1, we generated mesenchymal-cell-specific chondrocyte-specific Runx1-deficient mice [Prx1 Runx1(f/f) alpha1(II) mice, respectively] to circumvent embryonic lethality mice. We then mated these with mutant obtain or Runx1; double-mutant DKO respectively]. Prx1 displayed a delay sternal development...
Studies in postmenopausal women have shown that estrogen reduces circulating sclerostin levels, but effects of on skeletal mRNA levels are unknown.The objective the study was to evaluate short-term treatment bone and other genes relevant metabolism.Needle biopsies were obtained from 20 treated with transdermal for 3 weeks untreated controls. Quantitative PCR analyses used examine expression related metabolism, including 71 additional linked density/fracture genome-wide association...
Precise delineation of the specific genes and pathways altered with aging estrogen (E) therapy may lead to new skeletal biomarkers development novel bone therapeutics. Previous human studies, however, have been limited by only examining pre-specified pathways. High-throughput RNA sequencing (RNAseq), on other hand, offers an unbiased approach examine entire transcriptome. Here we present RNAseq analysis samples, obtained from iliac crest needle biopsies, yield first in vivo interrogation all...
We evaluated thumb pronation angles in patients with trapeziometacarpal joint osteoarthritis. Patients a significantly decreased angle showed moderate correlation the Eaton–Littler classification. Weakness of opponens pollicis function is associated development Level evidence: III
Estrogen receptor (ER) alpha and beta were expressed in the inner ear, expression decreased with increasing age. ERalpha may alter cochlear vestibular sensory transduction, ERbeta have a neuroprotective function ear.Expression of mouse ear its alterations sex aging analyzed.Male female CBA/J mice aged 8 weeks 24 months used. The localization intensity immunoreactivity young old both sexes investigated by immunohistochemistry.ERalpha co-expressed i.e. nuclei stria vascularis, outer hair...
ABSTRACT Although the role of ERα in regulating bone metabolism has been extensively studied, ERβ largely dismissed as a relevant modulator mass. Previous studies examining utilized germline knockout mouse expressing transcript variants and displaying systemic hormonal changes that confounded interpretation skeletal phenotype. Thus, we used conditional model to achieve deletion specifically early osteoprogenitor cells using Prx1-Cre driver. We observed marked increases trabecular volume...
Thumb opposition is vital for hand function and involves pronation palmar abduction. The improvement of often used as one the evaluation items opponensplasty method severe carpal tunnel syndrome. However, most studies substitution methods measurement angle. Thus, there still no appropriate measuring thumb angle accurately in syndrome patients. In recent reports, a wearable gyroscope was to evaluate upper extremity motions it can be possibly accurate along three-dimensionally moving bone...
In this case-control study, we concluded that women with distal radial fractures who were surgically treated showed lower grip strength and dynamic body balancing than those of controls. These results suggest measurements balance may be useful screening tools to assess future fracture risk. Patients (DRFs) are at risk fragility fractures. However, their physical characteristics tendencies for falls remain unclear. We aimed compare the without included 128 a DRF as first (fracture group)...
We have investigated mid-shaft stress fractures of the bowed femoral shaft (SBFs), well before first report an association between suppression bone turnover and atypical (AFFs). Although all cases SBF meet criteria for AFF, SBFs can also occur in patients with no exposure to suppression-related drugs (e.g., bisphosphonates). Using morphometry biomechanical analyses, we devised a theory AFF subtypes, dividing AFFs into fragility "typical" subtrochanteric caused by suppressed turnover. The aim...
Electrophysiological examination is important for the diagnosis and evaluation of nerve function in carpal tunnel syndrome (CTS). severity classifications CTS using a conduction study (NCS) have been reported, there are many reports on relationship between clinical symptoms. The existing electrophysiological several problems, such as cases that do not fit into classification unclear reasons boundary value. purpose this was to clarify sensory velocity (SCV) distal motor latency (DML) evaluate...
Early detection and intervention are essential for the mitigation of degenerative cervical myelopathy (DCM). However, although several screening methods exist, they difficult to understand community-dwelling people, equipment required set up test environment is expensive. This study investigated viability a DCM-screening method based on 10-second grip-and-release using machine learning algorithm smartphone equipped with camera facilitate simple system.Twenty-two participants comprising group...
Abstract Purpose: The risk of colorectal cancer is increased in patients with inflammatory bowel diseases, especially those ulcerative colitis (UC). Although 5-aminosalicylic acid (5-ASA) widely used the treatment UC to suppress colitic inflammation, no studies have been conducted examine chemopreventive effect 5-ASA, given remission phase colitis, against colitis-associated using animal models. We therefore investigated possible inhibition by peroxisome proliferator-activated receptor-γ...
There is increasing evidence that osteocytes regulate multiple aspects of bone remodeling through bi-directional communication with osteoblasts. This potentially mediated cell-cell contact via osteocytic dendritic processes, the activity secreted factors, or both. To test whether affects gene expression patterns in osteoblasts and osteocytes, we used a co-culture system where calvarial IDG-SW3 were allowed to touch porous membrane, while still being physically separated allow for phenotypic...