A5102997422- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Allergic Rhinitis and Sensitization
- Infective Endocarditis Diagnosis and Management
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Respiratory viral infections research
- Asthma and respiratory diseases
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Bacterial biofilms and quorum sensing
- Reproductive tract infections research
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Syphilis Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Neonatal and Maternal Infections
- Vaccine Coverage and Hesitancy
- Dermatology and Skin Diseases
FluGen (United States)
2024
Pfizer (United States)
2012-2022
Jean Brown Research
2016
Foothill Family Clinic
2016
Pearl River Community College
2013
Cerus (United States)
2010
Dynavax Technologies (United States)
2000-2009
United States Military Academy
1997-2004
Dynavax Technologies (Germany)
2002-2004
University of Pennsylvania
2004
Conjugating immunostimulatory sequences of DNA to specific allergens offers a new approach allergen immunotherapy that reduces acute allergic responses.We conducted randomized, double-blind, placebo-controlled phase 2 trial vaccine consisting Amb 1, ragweed-pollen antigen, conjugated phosphorothioate oligodeoxyribonucleotide sequence (AIC) in 25 adults who were ragweed. Patients received six weekly injections the AIC or placebo before first ragweed season and monitored during next two...
Immunostimulatory DNA sequences (ISS) are a potent Th1 adjuvant. We hypothesized that conjugation of ISS to protein antigens would strongly enhance their immunogenicity because both antigen and adjuvant be delivered the same locale/antigen-presenting cell. To test this hypothesis, we conjugated 22-mer immunostimulatory oligodeoxynucleotide (ISS-ODN) two differing intrinsic immunogenicity, namely Escherichia coli beta-galactosidase HIV-1 envelope glycoprotein gp120. show antigen-ISS...
Recent development of serogroup B meningococcal (MenB) vaccines highlights the importance pharyngeal carriage data, particularly in adolescents and young adults, to inform implementation strategies. We describe current UK prevalence this high risk population compare methods detection.In multisite study, swabs were collected on 3-4 occasions over 6-12 months, from 1040 school university students, aged 10-25 years. Meningococcal was detected by standard culture combined with seroagglutination...
ABSTRACT Synthetic oligonucleotides containing CpG motifs in specific sequence contexts have been shown to induce potent immune responses. We evaluated mucosal administration of two immunostimulatory (ISS)-containing phosphorothioate-stabilized for antiherpetic efficacy animal models. The ISS oligonucleotides, suspended phosphate-buffered saline, were tested mouse and guinea pig vaginal models herpes simplex virus type 2 (HSV-2) infection. For comparison, groups untreated, non-ISS...
A prophylactic Staphylococcus aureus four-antigen vaccine (SA4Ag) is under development for prevention of invasive S. disease. preliminary three-antigen (SA3Ag) was reformulated to include a novel manganese transporter protein (MntC or rP305A). This study describes the first-in-human dose-finding, safety, and immunogenicity results SA4Ag.In this double-blind, sponsor-unblind, placebo-controlled, phase 1/2 study, 454 healthy adults aged 18-64years were randomised receive single dose one three...
The decline in immune function with age is a challenge to vaccine development. Following an initial study adults aged 18–64 years, this evaluated the safety and immunogenicity of Staphylococcus aureus (S. aureus) 4-antigen (SA4Ag) 3-antigen (SA3Ag) older adults. SA3Ag included capsular polysaccharide serotypes 5 8 (CP5 CP8) conjugated nontoxic mutant form diphtheria toxin (CRM197) recombinant version clumping factor A (ClfA). SA4Ag these antigens, addition manganese transporter C (rP305A or...
Concomitant administration of bivalent rLP2086 (Trumenba [Pfizer, Inc] and diphtheria, tetanus, acellular pertussis inactivated poliovirus vaccine (DTaP/IPV) was immunologically noninferior to DTaP/IPV saline safe well tolerated. Bivalent elicited robust broad bactericidal antibody responses diverse Neisseria meningitidis serogroup B strains expressing antigens heterologous after 2 3 vaccinations. rLP2086, a (MnB) Inc]) recently approved in the United States prevent invasive MnB disease...
This study in healthy adolescents (11 to <18 years) evaluated coadministration of quadrivalent human papillomavirus vaccine (HPV-4), with bivalent rLP2086, a meningococcal serogroup B (MnB) vaccine.Subjects received rLP2086 + HPV-4, saline or HPV-4 at 0, 2 and 6 months. Immune responses antigens were assessed 1 month after doses 3. Serum bactericidal assays using complement (hSBAs) 4 MnB test strains expressing vaccine-heterologous factor H binding protein (fHBP) variants determined immune...
Eight hundred and twelve children, 12 months to 3.5 years of age, were enrolled in two clinical studies evaluate the safety immunogenicity a live, attenuated combination vaccine for measles, mumps, rubella, varicella (MMRV). Children one randomized, multicenter studies, involving administration (1) MMRV placebo vs. rubella (M-M-RII) varicella-zoster virus (VARIVAX), given at separate anatomic sites same office visit; or (2) MMRV, DTaP (diphtheria, tetanus, acellular pertussis vaccine) OPV...
Background: Bivalent rLP2086, targeting meningococcal serogroup B, will extend prevention of disease beyond that provided by quadrivalent ACWY vaccines; coadministration with recommended vaccines may improve adherence to vaccine schedules. This phase 2, randomized, active-controlled, observer-blinded study assessed whether immune responses induced Menactra (meningococcal A, C, Y and W-135 polysaccharide conjugate [MCV4]) Adacel (tetanus toxoid, reduced diphtheria acellular pertussis [Tdap])...
ObjectivesCurrent information on rates and dynamics of meningococcal carriage is essential for public health policy. This study aimed to determine prevalence, its risk factors duration in the Netherlands, where C vaccine coverage >90%. Several methods identify serogroups isolates among adolescent young adults were compared.MethodsOropharyngeal swabs collected from 1715 participants 13–23 years age 2013–2014; 300 prospectively followed over 8 months. Cultured characterized by Ouchterlony,...
We conducted a prospective study of 385 patients who had community-acquired pneumonia with use modified polymerase chain reaction (PCR) assay that detects amplified DNA by enzyme immunoassay (EIA). used PCR-EIA to improve detection Chlamydia pneumoniae infection and differentiate C. from other chlamydial infections. Cultures throat swab specimens four yielded species (C. pneumoniae, one patient; species, two patients; psittaci, patient). was repeatedly detected for thirteen (3.4%) these...
Neisseria meningitidis serogroup B (MnB) is a leading cause of bacterial meningitis; however, MnB most commonly associated with asymptomatic carriage in the nasopharyngeal cavity, as opposed to disease state. Two vaccines are now licensed for prevention disease; possible additional benefit these could be protect against indirectly by disrupting (e.g., herd protection). To investigate this possibility, accurate diagnostic approaches characterize isolates required. In contrast invasive...