A5013859921- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Genomics and Phylogenetic Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Crystallization and Solubility Studies
- Ginseng Biological Effects and Applications
- X-ray Diffraction in Crystallography
- Traditional Chinese Medicine Analysis
- Synthesis and biological activity
- Botanical Studies and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Plant and Fungal Species Descriptions
- Crystal structures of chemical compounds
- Traditional and Medicinal Uses of Annonaceae
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Plant Diversity and Evolution
- Food Quality and Safety Studies
- Plant Disease Resistance and Genetics
- Phytochemical Studies and Bioactivities
- Phytochemical compounds biological activities
- Fungal Biology and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Alkaloids: synthesis and pharmacology
Liaoning University of Traditional Chinese Medicine
2015-2024
Dalian University
2018
Sungkyunkwan University
2013
Liaoning University
2008-2011
Dalian Medical University
2008
Liaoning Normal University
2008
Hunan University
1997
Neural stem cells (NSCs) have therapeutic potential in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS); however, to date, their use has resulted only limited clinical and pathological improvement. To enhance capacity, the present study, we transduced bone marrow–derived NSCs (BM-NSCs) with neurotrophin 3 (NT-3), a potent neurotrophic factor that is both neuroprotective immunomodulatory. We found BM-NSCs NT-3 reduced central nervous system (CNS)...
Introduction Blechnopsis orientalis (L.) C. Presl is a medicinal and edible fern species belonging to the Blechnaceae family. Currently, complete mitochondrial genome of B. , as well those other species, remains unreported, studies on are limited. Methods In this study, was sequenced using both Nanopore PromethION Illumina NovaSeq 6000 platforms. Genome annotation performed MITOFY MFANNOT, with structural visualization via OGDRAW. In-depth analyses were conducted, including assessments...
Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role pathogenesis Alzheimer's disease (AD). Previous studies have demonstrated neuroprotective osthole against oxygen and glucose deprivation cortical neurons. However, effects on Aβ-induced neurotoxicity neural cells rarely been reported. The current study was designed to investigate protective a cell model AD insulted by exogenous Aβ25-35 potential mechanism(s). In this study,...
The present study was to investigate the neuroprotective effect of arctigenin, major active component a traditional Chinese medicine “Arctii Fructus”, against PD in rat model induced by rotenone.
In the present study, two new compounds, together with six known were isolated from rhizome of Atractylodes macrocephala Koidz by a series silica gel, ODS column chromatography, and preparative HPLC. Their structures characterized as atractylenolide II (1), I (2), biepiasterolid (3), isoatractylenolide (4), III (5), 3β-acetoxyl (6), (4E,6E,12E)-tetradeca-4,6,12-triene-8,10-diyne-13,14-triol (7), (3S,4E,6E,12E)-1-acetoxy-tetradeca-4,6,12-triene-8,10-diyne-3,14-diol (8) on basis 1D, 2D NMR,...
Baitouweng is a traditional Chinese medicine with long history of different applications. Although referred to as single medicine, actually comprised many closely related species. It therefore critically important identify the species that are utilized in these medicinal Knowledge about their phylogenetic relationships can be derived from chloroplast genomes and may provide additional insights into development molecular markers.Genomic DNA was extracted six Pulsatilla then sequenced on an...
Abstract Background Pulsatilla saxatilis , a new species of the genus has been discovered. The morphological information this well described, but its chloroplast genome characteristics and comparison with same remain to be reported. Results Our results showed that total length (cp.) P. is 162,659 bp, GC content 37.5%. cp. contains 134 genes, including 90 known protein-coding 36 tRNA 8 rRNA genes. demonstrated similar other . Herein, we compared genomes 10 species, found are extremely...
Tagetespatula L. is a widely cultivated herbal medicinal plant in China and other countries. In this study, two new 2, 3-dihydrobenzofuran glucosides (1, 2) fourteen known metabolites (3-16) were isolated from the stems leaves of T. patula (SLT). The chemical structures compounds characterized comprehensively based on one- two-dimensional NMR spectroscopy high resolution mass spectrometry. Absolute configurations 1 2 determined by ECD calculations. Compounds exhibited moderate vitro...
Five new monoterpene glycosides, rhodiolosides A-E (1-5), were isolated from the roots of Rhodiola rosea (Crassulaceae). Their structures elucidated as (2E,6E,4R)-4,8-dihydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glucopyranoside (1), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl alpha-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (2), beta-D-glucopyranosyl(1-->3)-beta-D-glucopyranoside (3), (2E,4R)-4,7-dihydroxy-3,7-dimethyl-2-octenyl (4), and (2E)-7-hydroxy-3,7-dimethyl-2-octenyl...
Currently, a pandemic swine influenza A virus infection causes huge negative impact on human beings all over the world. However, methods of treatment are not satisfactory, therefore it is urgent for us to set up new theory and practice fight against intractable virus. Terminalia chebula Retz., as kind traditional Chinese medicine, widely distributes has multiple pharmacological effects. Evidences in laboratory clinic confirm potential of Terminalia chebula Retz inhibiting infection. We thus...
Arctigenin (Arc) has been shown to act on scopolamine-induced memory deficit mice and provide a neuroprotective effect cultured cortical neurons from glutamate-induced neurodegeneration through mechanisms not completely defined. Here, we investigated the of Arc H89-induced cell damage its potential in mouse human SH-SY5Y neuroblastoma cells. We found that prevented viability loss induced by H89 Moreover, reduced intracellular beta amyloid (Aβ) production cells, also inhibited presenilin...
A new, simple, accurate and reliable full-time five-wavelength fusion method for the simultaneous separation determination of nine active chemical compositions (liquiritin apioside, liquiritin, isoliquiritin ononin, isoliquiritin, liquiritigenin, calycosin, isoliquiritigenin, Glycyrrhizic acid monoammonium salt) in traditional Chinese medicine Glycyrrhiza was developed using reverse phase high-performance liquid chromatography (RP-HPLC) coupled with a diode-array detector (DAD). The...
Ginseng (Panax ginseng C.A. Meyer) is one of the most widely used herbal medicines worldwide. The present study evaluated neuroprotective effects protein (GP) and its possible mechanisms in a cellular animal model AD. results demonstrated that GP (10-100 µg/mL) significantly improved survival rate neurons reduced cells' apoptosis mRNA expression caspase-3 Bax/Bcl-2. In addition, (0.1 g/kg) shortened escape latency, prolonged crossing times percentage residence time; level Aβ1-42 p-tau,...
Seven compounds were isolated from roots and stems of Oplopanax elatus, which 3, 4, 5 6 for the first time title plant; 1 2 are new characterised to be 3,3'-dimethoxy-4,9,9'-trihydroxy-4',7-epoxy-5'8-lignan-4,9-bis-O-beta-D-glucopyranoside 5-methoxylariciresinol-4-O-beta-D-glucopyranoside on basis NMR spectra CD spectrum.