A5019825374- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Cardiomyopathy and Myosin Studies
- Nursing education and management
- Higher Education Research Studies
- Heat shock proteins research
- Mentoring and Academic Development
- Homelessness and Social Issues
- Nitric Oxide and Endothelin Effects
- Nursing Education, Practice, and Leadership
- Health Sciences Research and Education
- MicroRNA in disease regulation
- Substance Abuse Treatment and Outcomes
- Receptor Mechanisms and Signaling
- Reflective Practices in Education
- Interprofessional Education and Collaboration
- Circular RNAs in diseases
- HIV/AIDS Research and Interventions
- Youth Development and Social Support
- Viral Infections and Immunology Research
- HIV, Drug Use, Sexual Risk
- Racial and Ethnic Identity Research
- Patient Satisfaction in Healthcare
- Meta-analysis and systematic reviews
University of Cincinnati Medical Center
2010-2024
University of Cincinnati
2007-2020
Applied Science Private University
2020
Centro de Biología Molecular Severo Ochoa
2011
Academy of Athens
2011
Sabin Vaccine Institute
2007-2010
University of Missouri
2009
Bassett Medical Center
2009
University of Wales
2005
Background— Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation cardiomyocyte death. However, the signature miRNA expression and possible ischemic heart been less well studied. Methods Results— We performed arrays to detect pattern miRNAs murine hearts subjected ischemia/reperfusion (I/R) vivo ex vivo. Surprisingly, we found that only miR-320 was significantly decreased on I/R This further confirmed by TaqMan real-time...
Background: Heat shock proteins (Hsp) are known to enhance cell survival under various stress conditions. In the heart, small Hsp20 has emerged as a key mediator of protection against apoptosis, remodeling, and ischemia/reperfusion injury. Moreover, been implicated in modulation cardiac contractility ex vivo. The objective this study was determine vivo role heart mechanisms underlying its regulatory effects calcium (Ca) cycling. Methods Results: overexpression intact animals resulted...
The Na(+)-K(+)-ATPase (NKA) is a transmembrane protein that sets and maintains the electrochemical gradient by extruding three Na(+) in exchange for two K(+). An important physiological role proposed vascular smooth muscle NKA regulation of blood pressure via modulation contractility (5). To investigate relations between level pressure, we developed mice carrying transgene either alpha(1)- or alpha(2)-isoform (alpha(1 sm+) alpha(2 mice) driven muscle-specific alpha-actin promoter SMP8....
College retention rates continue to be a national issue in the United States. Solutions decrease attrition have not been adequately tested nursing student population.The purpose of this study was investigate benefits peer-mentoring program baccalaureate from perspectives both mentor and mentee.Electronic surveys were used evaluate impact program.Responses showed beneficial academically, personally, professionally. A large majority (89%-96%) mentees agreed or strongly with positive effects...
Innovative strategies may support the Institute of Medicine's recommendation to increase number doctorally prepared nurses by 50% 2020. Moreover, implemented and diversity Doctor Philosophy (PhD)-prepared in particular.The purpose this article is describe approaches used one college nursing enact a research-doctorate pipeline initiative inspire diverse pool undergraduate students consider pursuing PhD degree. Principles that served as foundation for are identified.Sixteen students, with...
The Na(+)-K(+)-ATPase (NKA) can affect intracellular Ca(2+) concentration regulation via coupling to the Na(+)-Ca(2+) exchanger and may be important in myogenic tone. We previously reported that mice carrying a transgene for NKA alpha(2)-isoform smooth muscle (alpha(2sm+)), protein as well alpha(1)-isoform (not contained transgene) increased similar degrees (2-7-fold). Aortas from alpha(2sm+) relaxed faster KCl-induced contraction, hypothesized related more rapid clearance. To elucidate...
Impaired sarcoplasmic reticulum calcium cycling and depressed contractility are key characteristics in heart failure. Defects function characterized by decreased SERCA2a Ca-transport that is partially attributable to dephosphorylation of its regulator phospholamban increased protein phosphatase 1 activity. Inhibition through activation endogenous inhibitor-1 has been shown enhance cardiac Ca-handling as well protect from pathological stress remodeling young mice. In this study, we assessed...
Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic reticulum (SR) Ca2+ release by interacting with the ryanodine receptor. The levels of these significantly down-regulated in failing human hearts. However, significance such decreases is currently unknown. Here, we addressed functional role accessory heart's responses to ischaemia/reperfusion (I/R) injury. Isolated mouse hearts were subjected global I/R, contractile parameters assessed wild-type (WT),...
Background: Summer bridges facilitate the transition from high school to college. Although many schools employ summer bridges, few have published outcomes. This article's purpose is share preconceptions of college by underrepresented and disadvantaged nursing students describe important elements long-term impact a bridge, component Leadership 2.0 program. Method: A longitudinal study design was used collect baseline, short-term, post-summer bridge data. Methods included pre- postsurveys,...
This study examined students' conceptions of the relationship between aspects theory and practice in art, media design undergraduate education. was considered specifically relation to dissertation which most final-year arts undergraduates undertake. The based on interviews conducted within one institution where is normally delivered, supported assessed by tutors who teach student both practice. These practice/theory also supervise assess dissertation. An analysis a varied sample 24 students...
Arterial myocytes express α1-catalytic subunit isoform Na(+) pumps (75-80% of total), which are ouabain resistant in rodents, and high affinity α2-Na(+) pumps. Mice with globally reduced α2-pumps (but not α1-pumps), mice mutant ouabain-resistant α2-pumps, a smooth muscle (SM)-specific α2-transgene (α2 (SM-Tg)) that induces overexpression all have altered blood pressure (BP) phenotypes. We generated α2 (SM-DN) SM-specific (not α1) reduction (>50%) using nonfunctional dominant negative (DN)...
The purpose of this research study was to develop a theoretical framework explain the psychosocial process care initiation in individuals living with HIV, and identify critical junctures that influence HIV their decision initiate care. Grounded theory method used by HIV. Thirty (28 men, 2 women) shared stories about initiating Participants described which they progressed through five distinct stages following diagnosis: a) receiving news, b) interpreting c) incorporating d) acting on e)...
Abstract In 2020, the Dean of University Cincinnati College Medicine created a college-wide task force to address inequities in medical school curriculum. The consisted four workgroups, each co-chaired by faculty member and student. This co-leadership model was chosen because it provided diverse perspectives addressed typical faculty-student power differentials. balanced knowledge education curriculum with student experience. It also opportunity for co-chairs take on new roles leadership...
Colleges and universities are pivotal to successful efforts aimed at achieving greater nursing workforce diversity. In 2013, the College of Nursing University Cincinnati in Cincinnati, Ohio, introduced a multi-faceted program that supports underrepresented racial/ethnic minority disadvantaged students throughout four years baccalaureate curriculum. The Leadership 2.0: Nursing’s Next Generation has achieved impressive gains recruitment, retention, academic performance participants. This...
High ouabain affinity α2 Na + pumps are expressed in arterial smooth muscle (ASM). They help regulate blood pressure (BP) several forms of hypertension, but their influence on basal BP is controversial. We determined (telemetry), and the effects subcutaneous (sc) angiotensin II (Ang II) dietary salt in: 1) SM/Tg mice, which express an transgene controlled by α-actin (SM) promoter; 2) SM/DN a truncated gene, dominant negative for native pumps, SM myosin heavy chain promoter. Expression...