A5025201568- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Protein Kinase Regulation and GTPase Signaling
- X-ray Diffraction in Crystallography
- HIV Research and Treatment
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Protein Structure and Dynamics
- Mass Spectrometry Techniques and Applications
- Proteoglycans and glycosaminoglycans research
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Biochemical and Structural Characterization
- Enzyme Structure and Function
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Spectroscopy and Chemometric Analyses
- Bacteriophages and microbial interactions
- Nanocluster Synthesis and Applications
- Food Quality and Safety Studies
Institute of Advanced Chemistry of Catalonia
2014-2025
FC Barcelona
2018
Universitat de Barcelona
1997-2017
Instituto de Química Orgánica General
2016
Consejo Superior de Investigaciones Científicas
2015
Institute for Research in Biomedicine
2007-2013
Universitat Autònoma de Barcelona
1992-2002
Sanofi (Spain)
1998
In this work, a peptide for ocular delivery (POD) and human immunodeficiency virus transactivator were conjugated with biodegradable poly(lactic-co-glycolic acid) (PGLA)-polyethylene glycol (PEG)-nanoparticles (NPs) in an attempt to improve drug bioavailability. The NPs prepared by the solvent displacement method following two different pathways. One involved preparation of PLGA followed PEG conjugation (PLGA-NPs-PEG-peptide); other self-assembly PLGA-PEG PLGA-PEG-peptide copolymer NP...
c-Src is a non-receptor tyrosine kinase involved in numerous signal transduction pathways. The kinase, SH3 and SH2 domains of are attached to the membrane-anchoring SH4 domain through flexible Unique domain. Here we show intra- intermolecular interactions involving suggesting presence previously unrecognized additional regulation layer c-Src. We have characterized lipid binding by domains, their intramolecular interaction its allosteric modulation SH3-binding peptide or Calcium-loaded...
Abstract Acidic microenvironments in solid tumors are a hallmark of cancer. Inspired by that, we designed family pseudopeptidic cage‐like anionophores displaying pH‐dependent activity. When protonated, they efficiently bind chloride anions. They also transport through lipid bilayers, with their anionophoric properties improving at acidic pH, suggesting an H + /Cl − symport mechanism. NMR studies DPC micelles demonstrate that the cages within phase. The affinity and chloride‐exchange rate...
Although largely overlooked in peptide engineering, coordination chemistry offers a new set of interactions that opens unexplored design opportunities for developing complex molecular structures. In this context, we report artificial ligands fold into chiral helicates the presence labile metal ions such as FeII and CoII . Heterochiral β-turn-promoting sequences encode stereoselective folding define physicochemical properties their corresponding complexes. Circular dichroism NMR spectroscopy...
The reaction of the gold polymers containing bipyridyl and terpyridyl units, [Au(C≡CC15H10N3)]n [Au(C≡CC10H7N2)]n, with water-soluble phosphines 1,3,5-triaza-7-phosphatricyclo[3.3.1.13.7]decane 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane gives rise to formation four gold(I) alkynyl complexes that self-assemble in water (H2O) dimethyl sulfoxide (DMSO), through different intermolecular interactions, an impact on observed luminescence displayed by supramolecular assemblies. A...
Abstract Dynamic covalent chemistry combines in a single step the screening and synthesis of ligands for biomolecular recognition. In order to do that, chemical entity is used as template within dynamic combinatorial library interconverting species, so that stronger binders are amplified due efficient interaction with target. Here we employed whole A549 living cells mixture imines, which amplification reflects selective corresponding extracellular matrix. The polyamine showed strong matrix...
Abstract Exposure to acrylamide may lead different neurotoxic effects in humans and experimental animals. To gain insights into this poorly understood type of neurotoxicological damage, we used a multi-omic approach characterize the molecular changes occurring zebrafish brain exposed at metabolite, transcript protein levels. We detected formation adducts with thiol groups from both metabolites residues, leading quasi-complete depletion glutathione inactivation components thioredoxin system....
Signal transducer and activator of transcription (STAT) proteins play a crucial role in the activation gene response to extracellular stimuli. The regulation activity these require complex rearrangement domains. According established models, based on crystallographic data, STATs convert from basal antiparallel inactive dimer into parallel active one following phosphorylation. simultaneous analysis small-angle X-ray scattering data measured at different concentrations unphosphorylated human...
Despite heparin being the most widely used macromolecular drug, design of small-molecule ligands to modulate its effects has been hampered by structural properties this polyanionic polysaccharide. Now a dynamic covalent selection approach is identify new ligand for heparin, assembled from extremely simple building blocks. The amplified molecule strongly binds (KD in low μm range, ITC) combination electrostatic, hydrogen bonding, and CH-π interactions as shown NMR molecular modeling....
Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The supramolecular complexation of Tyr residues efficiently precludes their subsequent PTK-catalysed phosphorylation. Our results show a modulation PTK activity competitive substrate caging.
Abstract Acidic microenvironments in solid tumors are a hallmark of cancer. Inspired by that, we designed family pseudopeptidic cage‐like anionophores displaying pH‐dependent activity. When protonated, they efficiently bind chloride anions. They also transport through lipid bilayers, with their anionophoric properties improving at acidic pH, suggesting an H + /Cl − symport mechanism. NMR studies DPC micelles demonstrate that the cages within phase. The affinity and chloride‐exchange rate...
We propose an approach to efficiently compress and denoise multidimensional NMR spectral data, improving their corresponding storage, handling, analysis. This method has been tested with 2D homonuclear, 3D heteronuclear, phase-sensitive data shown be especially powerful for metabolomics studies.
In nuclear magnetic resonance (NMR) metabolomics, most of the studies have been focused on analysis one-dimensional proton (1D 1H) NMR, whereas other nuclei, such as 13C, or NMR experiments are still underrepresented. The preference 1D 1H metabolomics lies fact that it has good sensitivity and a short acquisition time, but lacks spectral resolution because presents high degree overlap. this study, growth metabolism yeast (Saccharomyces cerevisiae) was analyzed by two-dimensional (2D) 1H–13C...
A new type of galactose mimetics has been synthesized following a straightforward synthetic approach based on cyclohexene olefin aziridination reactions directed by hydroxyl substituents. These enantiomerically pure galacto-configured N-aminoaziridines are potent irreversible inhibitors Aspergillus oryzae and Escherichia coliβ-galactosidases.