A5061053704- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Bacterial Infections and Vaccines
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cancer Cells and Metastasis
- Caveolin-1 and cellular processes
- Acute Myeloid Leukemia Research
- Thyroid Disorders and Treatments
- Bone health and treatments
- LGBTQ Health, Identity, and Policy
- Pregnancy and preeclampsia studies
- Retinoids in leukemia and cellular processes
- Intimate Partner and Family Violence
- Attachment and Relationship Dynamics
- Sexuality, Behavior, and Technology
- Cancer-related molecular mechanisms research
- Urinary Tract Infections Management
- Glioma Diagnosis and Treatment
- Gender, Feminism, and Media
- Protein Degradation and Inhibitors
Centers for Disease Control and Prevention
2020-2025
National Center for Injury Prevention and Control
2025
University of North Carolina at Chapel Hill
2017-2025
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2020-2024
The Centers
2022
Oak Ridge Institute for Science and Education
2020
Oak Ridge Associated Universities
2020
Public Health Department
2017-2018
Dana-Farber Cancer Institute
2008-2014
University of South Carolina
2012
Prominin-1 (CD133) is a commonly used cancer stem cell marker in central nervous system (CNS) tumors including glioblastoma (GBM). Expression of Prom1 thought to parallel expression and function normal cells. Using RNA situ hybridization antibody tools capable detecting multiple isoforms Prom1, we find evidence for two distinct populations mouse brain. first expressed stem/progenitor cells the ventricular zone embryonic Conversely, adult brain low SVZ/SGZ zones but high rare widely...
Objectives. To estimate the association of state policies that define prenatal substance use as child abuse and mandate health care professionals report to protective services with congenital syphilis case rates. Methods. We used 2018 2022 US data on notifications National Notifiable Diseases Surveillance System. conducted linear regression a generalized estimating equation approach compare rates in states policy only, mandated reporting both polices neither policy. Results. After adjustment...
HIV-1 diversity is increasing in North American and European cohorts which may have public health implications. However, little known about non-B subtype the southern United States, despite region being epicenter of nation's epidemic. We characterized transmission clusters to identify extent strains are transmitted locally. conducted cross-sectional analyses partial pol sequences collected from 1997 2014 adults accessing routine clinical care Carolina (NC). Subtypes were evaluated using...
Intrahost viral sequence diversity can be evaluated over multiple genomic regions using next-generation sequencing (NGS) and scaled to population-level identify recent human immunodeficiency virus type 1 infection. Using Primer-ID NGS, we sequenced the reverse transcriptase (RT) env V1–V3 from persons with known infection dates, assessed mean (π) first quintile of pairwise distributions time. The receiver operating characteristic area under curve (AUC) RT combined showed excellent...
In 2016, Centers for Disease Control and Prevention initiated Strengthening the US Response to Resistant Gonorrhea (SURRG) in multiple jurisdictions enhance antibiotic resistant gonorrhea rapid detection response infrastructure evaluate impact of key strategies.Eight were funded establish or local gonococcal culture specimen collection sexually transmitted disease community clinics, conduct antimicrobial susceptibility testing (AST) laboratories, modify systems enhanced data communication...
Neisseria gonorrhoeae culture is required for antimicrobial susceptibility testing, but recovering isolates from clinical specimens challenging. Although many variables influence recovery, studies evaluating the impact of specimen collection timing and patient symptom status are limited. This study analyzed urogenital extragenital recovery data Centers Disease Control Prevention's Strengthening US Response to Resistant Gonorrhea (SURRG) program, a multisite project, which enhances local N....
Evaluating chlamydia prevalence trends from sentinel surveillance is important for understanding population disease burden over time. However, trend estimates data may be misleading if they do not account changes in risk profiles of individuals who are screened (case mix) and changing performance the screening tests used.We analyzed a 389,555 young women (1990-2012) 303,699 men (2003-2012) entering US National Job Training Program. This period follows introduction national programs designed...
Maternal thyroid function is a critical mediator of fetal brain development. Pregnancy-related physiologic changes and handling conditions blood samples may influence hormone biomarkers. We investigated the reliability biomarkers in plasma pregnant women under various conditions.
Background We investigated differences in gonococcal antimicrobial susceptibility by anatomic site among cisgender men who have sex with (MSM) using specimens collected through the Centers for Disease Control and Prevention's enhanced Gonococcal Isolate Surveillance Project Strengthening US Response to Resistant Gonorrhea. Methods During period January 1, 2018–December 31, 2019, 12 8 Gonorrhea sites urogenital, pharyngeal, rectal isolates from MSM sexually transmitted disease clinics. were...
Background The COVID-19 pandemic may have influenced partner-seeking and sexual behaviors of adults. Methods We examined cross-sectional survey data collected at the end first year (n = 1161) second 1233) by National Opinion Research Center's nationally representative, probability-based AmeriSpeak panel. Data were analyzed to (1) quantify behavioral changes across years, (2) examine in-person dating prevalence during 2, (3) assess risk perception for acquiring or HIV/STIs through new...
We analyzed syphilis case notifications in reproductive age women during 2013-2022. Late/unknown duration grew faster after 2020 (45.8% versus 17.9% annual growth pre-2020). Increased screening, inaccurate staging, delayed diagnosis, or increased incidence following clinical and partner services gaps may contribute to rises late/unknown cases.
Objectives. To examine long-term gonorrhea prevalence trends from a sentinel surveillance population of young people at elevated risk for gonorrhea. Methods. We analyzed annual cross-sectional urogenital screening data 191 991 women (2000–2017) and 224 348 men (2003–2017) 16 to 24 years age entering the National Job Training Program, US vocational training program. estimated among using an expectation-maximization algorithm incorporated into logistic regression account increases in test...
Background Black men who have sex with (BMSM) are disproportionately affected by sexually transmitted infections (STI), including chlamydia and gonorrhea. Transactional is an hypothesized risk factor for STI acquisition in BMSM. Methods We estimated the association of transactional incident chlamydia/gonococcal infection among BMSM using longitudinal data from a randomized trial Atlanta (2012–2015). were eligible inclusion if they tested human immunodeficiency virus (HIV)-antibody-negative...
Jurisdictions participating in Strengthening the US Response to Resistant Gonorrhea (SURRG) implemented specimen collection for culture and antimicrobial susceptibility testing from a sample of persons all genders (at multiple anatomic sites) attending sexually transmitted disease clinics community clinics. We describe percentage characteristics patients whose isolates demonstrated reduced (RS) azithromycin, ceftriaxone, or cefixime.
Background Syphilis, a sexually transmitted infection that can cause severe congenital disease when not treated during pregnancy, is on the rise in United States. Our objective was to identify US counties with elevated risk for emergence of primary and secondary (P&S) syphilis among women reproductive age. Methods Using case reports, we identified no cases P&S age 2017 1 or more 2018. county-level sociodemographic data, developed model predict score at risk. Results Of 2451 2017, 345...
In 2010 to 2017, rates of reported chlamydia decreased among young Black women but increased for White and all men. Because case can be influenced by changes in prevalence, screening, other factors, we compared prevalence trends a sentinel population with national rate understand potential drivers trends.Chlamydia was calculated annually 16- 24-year-old entrants the National Job Training Program (NJTP) 2017. An expectation-maximization-based maximum likelihood approach used adjust...
Abstract The relative proportion of cases primary and secondary syphilis among men who have sex with women reported through national case report data from 2010 to 2019 seemed stable overall were stratified by race/ethnicity, region, age group, but counts increased.
National chlamydia case rate trends are difficult to interpret because of biases from partial screening coverage, imperfect diagnostic tests, and underreporting. We examined the extent which these time-varying could influence reported annual rates.Annual rates among women aged 15 through 24 years 2000 2017 were obtained Centers for Disease Control Prevention's Center HIV/AIDS, Viral Hepatitis, STD, TB Prevention AtlasPlus tool. Estimates reporting completeness, test sensitivity specificity,...
ABSTRACT Neisseria meningitidis (Nm) and gonorrhoeae (Ng) are human pathogens that sometimes occupy the same anatomical niche. Ng, causative agent of gonorrhea, infects 87 million individuals annually worldwide is an urgent threat due to increasing drug resistance. Ng a pathogen urogenital tract may infect oropharyngeal or rectal site, often asymptomatically. Conversely, Nm opportunistic pathogen. While commensal in tract, it also leading cause bacterial meningitis with 1.2 cases globally,...