A5076190842- Trypanosoma species research and implications
- Leprosy Research and Treatment
- Research on Leishmaniasis Studies
- Cardiomyopathy and Myosin Studies
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Healthcare Systems and Reforms
- Toxin Mechanisms and Immunotoxins
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Data-Driven Disease Surveillance
- Infectious Diseases and Tuberculosis
- Dermatological diseases and infestations
Administración Nacional de Laboratorios e Institutos de Salud
2002-2016
Ministerio de Salud
2008
Despite the strong immune responses elicited after natural infection with Trypanosoma cruzi or vaccination against it, parasite survival suggests that these are insufficient inherently inadequate. T. contains a major cystein proteinase, cruzipain, which has catalytic N-terminal domain and C-terminal extension. Immunizations employed recombinant cruzipain its N- domains allowed evaluation of ability to circumvent domain. This phenomenon is not property but itself, because triggers response...
Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported presence sulfate groups in N-linked oligosaccharide chains this domain. In order to evaluate immune responses sulfated moieties on Cz, BALB/c mice were immunized purified Cz and C-T prior after desulfation treatment. The humoral response sulfates or was mainly IgG2b. Interestingly, abolishment IgG2b reactivity when...
BACKGROUND Corrientes, a province of northeastern Argentina with endemic leprosy, has improved its epidemiological indicators, however, study the dynamics over time is lacking. OBJECTIVES We analysed data 1308 leprosy patients between 1991 to 2014, and forecast for 2020. METHODS Descriptive statistics stepwise Bayesian model selection were performed. Forecasts made using median 100,000 projections parameters calculated via Monte Carlo methods. RESULTS found decreasing number new cases (-2.04...
SUMMARY Establishing the putative links between sylvatic and domestic transmission cycles of Trypanosoma cruzi , etiological agent Chagas disease, is public health relevance. We conducted three surveys to assess T. infection in wild mammals from a rural preserved area Misiones Province, Northeastern Argentina, which had recently been declared free vector- blood-borne human infection. A total 200 were examined by xenodiagnosis (XD) and/or polymerase chain reaction (PCR) amplification...
Tc 13 is a trans -sialidase family protein of Trypanosoma cruzi , the aetiological agent Chagas' disease. Recently, in vitro studies had suggested that might participate pathogenesis In order to study role antigens an vivo model, we administered plasmid DNA encoding antigen from Tulahuén strain ( Tul) BALB/c mice and evaluated immunological pathological manifestations as well capacity this confer protection against T. infection. Tul immunization did not elicit detectable humoral immune...
Chagasic cardiomyopathy is a major life-threatening complication of Trypanosoma cruzi infection in human beings. This study focuses on the hypertrophic and hyperplastic mechanisms underlying structural changes heart during experimental infection. Proliferating cell nuclear antigen (PCNA) expression, transversal diameter, area, number nuclei per unit volume were determined ventricular myocytes T. cruzi-infected Wistar rats. PCNA expression was enhanced throughout inflamed myocardium spared...
SUMMARY We have previously reported that genetic immunization with Tc 13Tul antigen of Trypanosoma cruzi , the aetiological agent Chagas' disease, triggers harmful effects and non-protective immune responses. In order to confirm role 13 antigens during T. infection, herein we studied humoral cellular responses molecule its EPKSA C-terminal portion in BALB/c -infected mice or immunized recombinant 13Tul. Analysis antibody response showed B-cell epitopes stimulate a sustained IgM production...
Leprosy is a chronic, neglected tropical infectious disease, currently endemic in Formosa, province northwestern Argentina. To analyze the performance, distribution, and effectiveness of health system leprosy diagnosis we estimated trend number new cases diagnosed between 2002 2019 forecast for 2022 at primary care centers (PHCCs) first level (1stLC), district hospitals (DHs) second (2ndLC), high-complexity third (3rdLC), rural urban areas. The general was calculated based on detection rate...
Background The province of Formosa, Argentina, is endemic for leprosy. In the present paper, we assessed trend (T, 2002–2016 time series) and forecast 2022 new case detection rate (NCDR) determined spatial distribution cases detected (NCD) Methodology/Principal findings This a descriptive observational study 713 NCD leprosy from provincial medical records between January 2002 December 2016. whole dataset record was used to independently estimate NCDR trends general population, age groups,...