A5051073794- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy and preeclampsia studies
- Venous Thromboembolism Diagnosis and Management
- Renin-Angiotensin System Studies
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Chronic Kidney Disease and Diabetes
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Apelin-related biomedical research
- Chemical synthesis and alkaloids
Islamia University of Bahawalpur
2021
Heidelberg University
2008-2010
University Hospital Heidelberg
2009
Introduction: Thrombomodulin (TM) is predominantly a vascular endothelial cell plasma membrane glycoprotein that, via distinct structural domains, interacts with multiple ligands, thereby modulating coagulation, fibrinolysis, complement activation, inflammation and proliferation. We have previously shown that TM protects against diabetic nephropathy (DN) through activation of protein C(PC), which inhibits glomerular apoptosis. Recent studies showed mediates cytoprotective effects independent...
Objective: The thrombomodulin (TM) protein C (PC) system is an endothelial dependent, cytoprotective which has been initially identified based on its anticoagulant function. Following binding and inactivation of thrombin the complex TM activates PC via EGF-domains 4–6. Activated (APC) as well properties. In addition mediates a direct effect through lectin-like domain (LD), potentially scavenging HMGB-1 thus preventing excess activation receptor RAGE. role this for diabetic microvascular...
Molecular docking is a powerful and significant approach for the identification of lead molecules on basis virtual screening. With it large number compounds can be tested based scoring function ranking, conclusion made about how selected inhibit targeted protein/receptor. Considering importance selective inhibitors cholinesterase in treatment Alzheimer disease, this research focused determination mechanism binding interactions few benzene-1,3-diol derivatives within active site both...
Activated protein C (APC) exerts anti-coagulant, anti-inflammatory and anti-apoptotic activities. We have recently shown that APC modulates diabetic nephropathy by inhibiting endothelial podocyte apoptosis. The cyto-protective effects of on cells require receptor (EPCR) protease activated receptor-1 (PAR-1). However, it is not known how regulates function.