A5028025237- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory Biomarkers in Disease Prognosis
- Peroxisome Proliferator-Activated Receptors
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Trigeminal Neuralgia and Treatments
- Cerebral Venous Sinus Thrombosis
- Pancreatic and Hepatic Oncology Research
- Facial Nerve Paralysis Treatment and Research
- Medical Imaging Techniques and Applications
- Blood transfusion and management
- Abdominal Trauma and Injuries
- Radiation Dose and Imaging
- Brain Tumor Detection and Classification
- Sphingolipid Metabolism and Signaling
- Artificial Intelligence in Healthcare and Education
- Adrenal and Paraganglionic Tumors
Shenzhen Second People's Hospital
2016-2024
Shenzhen University
2017-2024
Shenzhen University Health Science Center
2020-2023
Chinese PLA General Hospital
2014
Shenyang Agricultural University
2014
Shanxi Provincial Cancer Hospital
2011-2014
Pituitary adenoma (PA) includes invasive pituitary (IPA) and noninvasive (NIPA), which are associated with the endocrine system. The gut microbiome plays an important role in human metabolism, but association between remains unclear. A total of 44 subjects were enrolled this study. Of these, 29 PA patients further divided into IPA ( n = 13) NIPA 16), while 15 healthy age-matched defined as control subjects. We collected faecal samples characterized microbial profiles by metagenomic...
To compare the clinical outcomes and complications of 247 pituitary tumor patients managed by endoscopic microscopic approaches in our hospital.The authors performed a retrospective review 100 treated endonasal transsphenoidal surgery (ETS) 147 (MTS) at center from January 2007 to July 2014. The tumors were stratified Knosp classification modified Hardy classification, gross total resection (GTR)/remission rate, visual improvement complications, operation time, intraoperative bleeding length...
Background The purpose of this research was to synthesize the American College Surgeons National Surgical Quality Improvement Program database investigate link between preoperative hematocrit and postoperative 30-day mortality in patients with tumor craniotomy. Methods A secondary retrospective analysis electronic medical records 18,642 craniotomy 2012 2015 performed. principal exposure hematocrit. outcome measure mortality. We used binary logistic regression model explore them conducted a...
The authors presented our institutional experience with skull base reconstruction techniques and developed a stratified algorithm for different causes of cerebrospinal fluid (CSF) leak. This is retrospective review patients who were diagnosed as CSF leak treated or underwent endoscopic transsphenoidal surgery sellar parasellar lesions at department from August 2012 to April 2017. totally identified 57 (59 operations in total) divided into 3 groups according the techniques. All specific focus...
Objective: Rathke cleft cysts (RCC) are benign sellar lesions, and endoscopic endonasal surgery (EES) for symptomatic RCC is becoming increasingly popular, but total resection or partial (TR PR) of the cyst wall still inconclusive. The aim this study was to review complications clinical prognoses associated with by EES. Methods: We retrospectively analyzed a series 72 patients treated EES from -January 2011 June 2019 at Shenzhen University First Affiliated Hospital. For these cases, 30 were...
Glioblastoma multiforme (GBM) is the most frequent, lethal, and aggressive tumor of central nervous system in adults. In this study, we found for first time that moschamindole (MCD), a rare phenolic amide with 8/6/6/5/5 rings, major bioactive constituent derived from Phragmites communis Trin (Poaceae) exhibits potential cytotoxic effect on both TMZ‐resistant GBM cell lines xenograft models. MCD‐induced intrinsic apoptosis signals mitochondrial dysfunction were confirmed by cycle arrest,...
PPARγ agonists have been reported to induce cell death in pituitary neuroendocrine tumor (PitNET) cultures. However, the therapeutic effects of vivo remain unclear. In present study, we found that intranasal 15d-PGJ2, an endogenous agonist, resulted growth suppression Fischer 344 rat lactotroph PitNETs induced by subcutaneous implantation with a mini-osmotic pump containing estradiol. Intranasal 15d-PGJ2 reduced volume and weight gland level serum prolactin (PRL) PitNETs. treatment...
Abstract Background Evidence regarding the relationship between preoperative platelet and 30-day postoperative mortality of intracranial tumor patients undergoing craniotomy is still limited. Therefore, present research was conducted to explore link mortality. Methods Electronic medical records 18,642 adult for brain tumors from 2012 2015 in American College Surgeons National Surgical Quality Improvement Program, were subject secondary retrospective analysis. A binary logistic regression...
Craniopharyngioma is an uncommon intracranial tumor that primarily occurs in the sella turcica. Giant cystic craniopharyngioma rare general and extremely adults. We report a case of giant anterior pontine cisterna suprasellar cisterna. A 27-year-old man presented with double vision, craniocerebral MRI revealed masses The were removed surgically diagnosed as large craniopharyngiomas by pathology MRI. Through this report, we hope to increase awareness disease among various clinicians,...
The identification of patients with craniotomy at high risk for postoperative 30‑day mortality may contribute to achieving targeted delivery interventions. present study aimed develop a personalized nomogram and scoring system predicting the in such patients. In this retrospective cross‑sectional study, 18,642 were stratified into training cohort (n=7,800; year surgery, 2012‑2013) an external validation (n=10,842; 2014‑2015). least absolute shrinkage selection operator (LASSO) model was used...
<title>Abstract</title> Our previous studies demonstrated the potential of Notoginsenoside R1 (NGR1), a primary bioactive compound from <italic>Panax notoginseng</italic>, in alleviating diabetic encephalopathy db/db mice and mitigating amyloid-β (Aβ)-induced neuronal damage. However, impact NGR1 on cognitive dysfunction Alzheimer’s disease (AD) mouse model remains unclear. In this investigation, we identified as novel PPARγ agonist through dual-luciferase reporter assay system. treatment...
Background Reliable quantification of the association between hypertension requiring medication and postoperative 30-day mortality in adult patients who undergo craniotomy for tumor resection is limited. We aimed to explore associations these factors. Materials methods This work was a retrospective cohort study that used propensity score matching (PSM) among 18,642 participants from American College Surgeons National Surgical Quality Improvement Program database 2012 2015. Hypertension were...
This study investigated the impact of endoscopic transnasal pituitary adenoidectomy on function and discussed factors that contribute to postoperative function. To provide a foundation for protecting improving curative effect adenoma neuroendoscope resection.
Objective To explore the correlation between iodine content(IC)calculated from gemstone spectral imaging scan and parameters of perfusion measured with CT, to determine their sensitivities specificities. Methods 20 patients pathologically diagnosed as lymphoma received get including blood flow(BF), volume(BV), mean transit time(MTT)and permeability surface(PS)from CT IC CT. The relationship was analyzed. Receiver operating characteristic(ROC)curve performed cut-off values,...
Abstract Background Primary facial spasm accompanied by arrhythmia is a rare clinical phenomenon and has not been reported before. We describe this discuss its mechanism treatment. Case presentation herein present case of patient with left primary third-degree atrioventricular block (III degree AVB), who was implanted temporary cardiac pacemaker to receive microvascular decompression (MVD) because refusal permanent pacemaker. The symptoms disappeared after MVD. removed on the second day...
Objective To investigate the application of three stages enhanced scan multi-slice spiral CT for characteristic analysis on wall and lumen colorectal mucous adenocarcinoma.Methods 51 patients with mucinous adenocarcinoma who had complete pathologic diagnosis were studied.GE Discovery 750HD scanner was used line scan,arterial portal venous phase scan,and delayed scan.The lesions intestinal wall,enteric cavity proximal normal observed by related quantitative value observed.Results The uneven...
Objective To evaluate the value of CT and MRI in diagnosis littoral cell angioma(LCA) spleen. Methods CT findings data 6 patients with LCA were rospectively analyzed, all proved spleen by pathology. Then enhanced CT(n= 4 cases)and MRI(n= 2 cases) performed. The imaging performance was observed,and its features summarized. Results None showed obvious signs symptoms hypersplenism,4 cases splenomegaly.5 had a single lesion, only one few lesions. There not any calcification or...