A5074442073- Prostate Cancer Treatment and Research
- Neuroscience and Neuropharmacology Research
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Memory and Neural Mechanisms
- Renal and related cancers
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Hippo pathway signaling and YAP/TAZ
- Xenotransplantation and immune response
City of Hope
2020-2024
Beckman Research Institute
2020-2024
University of California, Riverside
2015-2018
Loma Linda University
2016
Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant (CRPC). While more potent AR antagonists and blockers androgen synthesis were developed to improve clinical outcomes, they also show induce diverse CRPC phenotypes. Specifically, AR- neuroendocrine-null PCa, DNPC, occurs abiraterone enzalutamide-treated...
Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neurological, affective disorders. Our study focused on long-term behavioral deficits after repeated injury in which mice received either a single mild CHI (mCHI), (rmCHI) consisting one impact each hemisphere separated by 3 days, or moderate controlled cortical (CCI). Shams only anesthesia. Behavioral tests were administered at 1, 3, 5, 7, 90 days post-injury (dpi)....
Androgen/androgen receptor (AR) signaling pathways are essential for prostate tumorigenesis. However, the fundamental mechanisms underlying AR functioning as a tumor promoter in inducing prostatic oncogenesis still remain elusive. Here, we demonstrate that subpopulation of Osr1 (odd skipped-related 1)-lineage cells functions progenitors Single cell transcriptomic analyses reveal aberrant activation these elevates insulin-like growth factor 1 (IGF1) and initiates oncogenic transformation....
The androgen receptor (AR)-signaling pathways are essential for prostate tumorigenesis. Although significant effort has been devoted to directly targeting AR-expressing tumor cells, these therapies failed in most cancer patients. Here, we demonstrate that loss of AR stromal sonic-hedgehog Gli1-lineage cells diminishes epithelial oncogenesis and development using vivo assays mouse models. Single-cell RNA sequencing other analyses identified a robust increase insulin-like growth factor (IGF)...
Androgens/androgen receptor (AR) mediated signaling pathways are essential for prostate development, morphogenesis, and regeneration. Specifically, stromal AR-signaling has been shown to be prostatic initiation. However, the molecular mechanisms underlying AR-initiated mesenchymal-epithelial interactions in development remain unclear. Here, using a newly generated mouse model, we directly addressed fate role of genetically marked AR-expressing cells during embryonic development. Androgen...
ABSTRACT Stromal androgen-receptor (AR) action is essential for prostate development, morphogenesis and regeneration. However, mechanisms underlying how stromal AR maintains the cell niche in support of pubertal prostatic epithelial growth are unknown. Here, using advanced mouse genetic tools, we demonstrate that selective deletion expression prepubescent Shh-responsive Gli1-expressing cells significantly impedes development. Single-cell transcriptomic analyses showed loss these dysregulates...
Abstract Prostate cancer is the second most common in men worldwide. The current treatment targeting androgen receptor (AR) expressing cells, deprivation therapy (ADT), eventually fails prostate patients who consequently develop castration resistant cancer, an incurable disease. Although significant effort has been devoted to understanding promotional role of AR action tumor there urgent need define specific stromal tumorigenesis and needs be evaluated for designing effective therapy.We...