A5064004511- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Cancer Research and Treatments
- Colorectal Cancer Surgical Treatments
- Cytokine Signaling Pathways and Interactions
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- Cervical Cancer and HPV Research
- Bariatric Surgery and Outcomes
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Body Contouring and Surgery
- Cardiac Imaging and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Protein Degradation and Inhibitors
University of Southern California
2020-2022
Health Biomed (China)
2021
Emory University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
First Affiliated Hospital of Chinese PLA General Hospital
2016
Chinese PLA General Hospital
2013
Background Immunogenic cell death (ICD) is a tumor involving both innate and adaptive immune responses. Given published findings that oxaliplatin, but not irinotecan, drives ICD, we investigated whether single nucleotide polymorphisms (SNPs) in the ICD pathway are associated with efficacy of oxaliplatin-based chemotherapy metastatic colorectal cancer (mCRC). Methods Two randomized clinical trials data were analyzed: discovery cohort, FOLFOX/bevacizumab arm (MAVERICC); validation...
Women with symptoms or signs of myocardial ischemia but no obstructive coronary artery disease (INOCA) often have vascular dysfunction and elevated risk for adverse cardiovascular events. We hypothesized that u-hscTnI (ultra-high-sensitivity cardiac troponin I), a sensitive indicator ischemic cardiomyocyte injury, is associated in women INOCA. Approach Results: (N=263) INOCA enrolled the WISE-CVD study (Women's Ischemic Syndrome Evaluation-Coronary Vascular Dysfunction) underwent invasive...
190 Background: Wnt signaling deregulation is a primary driver of colorectal carcinogenesis. RNF43 key suppressor activation while R-Spodin inhibits activity. mutations are associated with the serrated neoplasia pathway, BRAF mutation and MSI. We hypothesized that genetic variants in R-Spodin/RNF43 complex corresponding genes expression levels may predict cetuximab efficacy mCRC pts. Methods: Genomic DNA from blood samples pts enrolled randomized FIRE-3 trial was genotyped through OncoArray,...
Objective To analyze the effectiveness and safety of laparoscopic sleeve gastrectomy (LSG) in treating obesity its co-morbidities.Methods The clinical data obese patients undergoing LSG Peking Union Medical College Hospital from August 2012 to 2017 were retrospectively analyzed. Medium-term outcome measures included excess weight loss (%EWL),co-morbidity improvement,and complications.Results Seventy-five comprising 28 men[ body mass index(BMI):(47.3±7.5)kg/m 2) ] 47 women [BMI (41.1±7.0)...
170 Background: Germline polymorphisms in CCR5 have been associated with treatment outcome pts mCRC receiving regorafenib and cetuximab-based treatment. Δ32, a loss of function deletion, plays key role infectious diseases but data CRC are scarce. We tested whether CCR Δ32 gene expression may be first-line Methods: The impact was evaluated 614 enrolled the randomized FIRE-3 trial (FOLFIRI/cetuximab, cet, n = 313; FOLFIRI/bevacizumab, bev, 301). Gene 102 FOLFIRI/cet arm from 155 treated...
3535 Background: The intracellular DNA sensor stimulator of interferon genes (STING) plays a vital role in anti-tumor immune responses by recognition self-DNA from tumors and by-products genomic instability. Activation STING was reported to enhance cetuximab mediated natural killer cell activation dendritic maturation. Previous reports suggested that polymorphisms cGAS-STING can affect innate response. Therefore, we hypothesized genetic variants the pathway may predict first-line treatment...
232 Background: BRD4 plays an important role in transcription, DNA repair and drug resistance. High expression polymorphisms of regulating pathways were reported to be related worse prognosis colorectal cancer. Therefore, we hypothesized that genetic variants pathway may predict first-line treatment outcome mCRC pts. Methods: The impact on 22 SNPs 7 genes involved (BRD4, SIPA1, MYC, 53BP1, H2AX, BATF, CD47) was analyzed through the OncoArray, a customized array manufactured by Illumina,...
187 Background: ICD is an immune response against dead-cell antigens from cancer cells treated with cytotoxic and/or targeted therapies. Oxaliplatin (OHP) and cetuximab (Cet) are distinct drugs to elicit ICD, while most other anticancer agents kill in a nonimmunogenic manner. We hypothesized that genetic variants ICD-related genes could predictive efficacy of OHP Cet mCRC. Methods: analyzed data mCRC patients enrolled three 1st-line randomized trials [FIRE-3: FOLFIRI+Cet vs...
Background: Activation of stimulator interferon genes (STING) was reported to enhance cetuximab mediated natural killer cell activation and dendritic maturation. Polymorphisms in cGAS-STING pathway may affect innate immune response. Therefore, we hypothesized that genetic variants the predict efficacy cetuximab-based treatment metastatic colorectal cancer (mCRC) patients.Methods: Genomic DNA from blood samples patients enrolled FIRE-3 (cetuximab arm, n=129; bevacizumab n=107) TRIBE...
3139 Background: Protection of replication forks is critical for the survival cancer cells. Chemotherapeutic drugs such as oxaliplatin and irinotecan can impede progression by inducing DNA lesions, which cause fork collapse generate double-strand breaks. We hypothesized that functional genetic variants in genes involved maintenance may predict efficacy cytotoxic mCRC patients. Methods: analyzed genomic clinical data from MAVERICC, a phase II trial compared mFOLFOX6 FOLFIRI combination with...