A5059518919- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Multiple Sclerosis Research Studies
- Acute Ischemic Stroke Management
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- COVID-19 and Mental Health
- CNS Lymphoma Diagnosis and Treatment
- Migraine and Headache Studies
- Intensive Care Unit Cognitive Disorders
- Cardiovascular and Diving-Related Complications
- Respiratory viral infections research
- Glioma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Systemic Lupus Erythematosus Research
- Plant and soil sciences
- Spondyloarthritis Studies and Treatments
- Information Technology and Learning
- Appendicitis Diagnosis and Management
- Balance, Gait, and Falls Prevention
- Vitamin K Research Studies
- Frailty in Older Adults
- Muscle activation and electromyography studies
Hospital General Universitario de Alicante Doctor Balmis
1999-2025
Instituto de investigación sanitaria y biomédica de Alicante
2021-2025
Universitat de Miguel Hernández d'Elx
2023-2024
Hospital Universitario Reina Sofía
2022
Marqués de Valdecilla University Hospital
2021
Hospital Marina Baixa
2003-2016
Shanghai Museum
2014
Andalusian Health Service
2011
Hospital Regional Universitario de Málaga
2011
This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, evaluate acute infection phase associated risk factors.A prospective cohort adult patients who had recovered from (27th February 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10-14 weeks after disease onset. PCS was defined as persistence at least one clinically relevant symptom, abnormalities in spirometry chest radiology. Outcome predictors were...
Abstract Background Frailty is a physiological condition characterized by decreased reserve to stressors. In patients with COVID-19, frailty risk factor for in-hospital mortality. The aim of this study was assess the relationship between clinical presentation, analytical and radiological parameters at admission, outcomes according frailty, as defined Clinical Scale (CFS), in old people hospitalized COVID-19. Materials methods This retrospective cohort included aged 65 years older admitted...
Multiple sclerosis patients who discontinue using natalizumab are at risk of a rebound in disease activity. However, the optimal alternative therapy is not currently known.We report on clinical and MRI data patient safety group relapsing-remitting multiple tested seropositive for JC virus have switched from to fingolimod because concerns regarding PML risks.The test antibodies was performed 18 were being treated with more than 1 year. Eight while seronegative continued natalizumab.After...
Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (≥ 15 years) and identify key risk factors according age. We designed a retrospective at Dr. Balmis General University Hospital (Alicante, Spain), including patients for from 2016 2022. In-hospital death was expressed as the case fatality rate (CFR). Variables yielding p value under 0.1 on univariable analysis were included multivariable logistic regression...
The aim of the study was to describe effectiveness and safety data rituximab in a group patients with relapsing-remitting multiple sclerosis (MS) treated due failure previous treatments or concomitant autoimmune diseases.This is an observational study. Rituximab considered case second-line therapy, first-line therapy contraindication therapies, disease. Relapses, Expanded Disability Status Scale, EQ VAS, magnetic resonance imaging activity were assessed.This included 12 MS. mean (range) age...
A 38-year-old woman with no significant past medical history presented a generalised tonic–clonic seizure. The patient was afebrile and general physical neurological examinations were normal. MRI of the brain revealed an irregular mass in right temporal lobe T2-weighted fluid-attenuated inversion recovery (FLAIR) signal hyperintensity heterogeneous enhancement after administration gadolinium (figure 1A–D). Laboratory investigations included normal blood count, liver enzymes, serum...
Low bone mineral density (BMD) and vertebral fractures (VF) have been associated with atherosclerosis in the general population. We sought to investigate relationship between BMD VF carotid women systemic lupus erythematosus (SLE).We studied 122 SLE. All patients had BMD, intima-media thickness (IMT), artery atherosclerotic plaque assessment by ultrasound.Mean age at study entry was 44 years mean disease duration 11 years. Carotid found 13 (11%) (9 postmenopausal 4 premenopausal). Patients...
Atherosclerosis affects the vascular system in a diffuse way and its is clearly implicated some of most prevalent diseases western countries such as cerebrovascular cardiovascular diseases. Knowing more about underlying pathogenic mechanisms may contribute to better understanding this entities development therapies for both treatment prevention.We review herein concepts included term atherosclerosis, growth atheromatous plaque complications cellular which intervene development. We analyze...
Genetic myopathies constitute a collection of rare diseases that significantly impact patient functionality and quality life. Early diagnosis genetic can prevent future complications provide families with counselling. Despite the substantial on adult population, global epidemiology these disorders is inadequately addressed in literature.
: The aim of the following cross-sectional study is to determine association between human leukocyte antigen (HLA) alleles and outcomes in patients presenting emergency department (ED) with SARS-CoV-2 infection.
The demand for neurological care depends on the type of population to be attended, among other variables. Marina Baixa area, which includes towns such as Altea and Benidorm, has its own peculiar characteristics due being one places that is often chosen by pensioners from northern central Spain Europe set up residence.The aim this study was determine ambulatory in our health area.Data 1,000 patients attended Neurological Clinic at Specialty Centre Benidorm (age, sex, reason visit, tests...
The first reports of neuropathy due to treatment with statins appeared in 1994, although it is an infrequent complication. It usually consists axonal polyneuropathy, which predominantly sensory, distal and symmetric, may be subacute or chronic. We present here the second case reported literature multiple mononeuropathy associated use statins.A 51-year-old female patient who, after beginning therapy pravastatin, presented progressive, asymmetrically distributed, paresthesias limbs unstable...
Abstract Background: Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective this study is to analyze the selective involvement different cognitive domains and existence related biomarkers. Methods: Cross-sectional multicentric patients who survived with consecutively recruited between 90 120 days hospital discharge. All underwent an exhaustive...
Leukoaraiosis is commonly found in neuroimaging ancient people. The pathogenic theory that most suitably explains its origin the vascular one, mainly linked to cerebral hemodynamic abnormalities. techniques frequently used evaluation (PET and SPECT) are expensive not widespread. Transcranial Doppler instead cheaper much more widespread.Our aim has been show whether transcranial a useful tool for leukoaraiosis.We have prospectively included 116 patients aged 60-90 who came Neurology...
Studies conducted in the American population have revealed existence of differences cerebral vascular pathologies and prevalence risk factors between races. The few studies carried out Hispanic populations found a higher diabetes mellitus, as well lower frequency cardioembolic strokes extracranial carotid atheromatosis, comparison with whites Anglo-Saxon extraction.We performed case-control study which one case was paired two controls, according to age sex. cases were people from Central...
Several infectious agents have been found to be involved in atherogenesis over the past decade. Chlamydia pneumoniae is one of commonest associated agents. In this study we analysed possible relationship between a high level antibodies Chlamydia, and presence carotid ultrasound changes patients who had strokes.We studied 230 admitted consecutively Stroke Unit our hospital, with diagnosis stroke. All group duplex studies assess degree stenosis. these also serological using...
Headache is one of the commonest causes consultation in neurology. There are many studies prevalence migraine showing considerable variation results obtained.To find migraine, with and without an aura, by means a randomized transverse study carried out previously selected rural population, using validated questionnaire 'Alcoi-92'. To overall specifically regarding age sex adjusted for European population.A door-to-door was made random selection 790 persons aged over 18, three towns comarca...
Headache is one of the commonest reasons for consultation and it might be useful to know its characteristics in order determine which patients may need medical attention.To carry out a randomized transverse study rural population using validated questionnaire 'Alcoi-92', clinical headaches detected.A door survey was done by selection 790 persons aged over 18 living Comarca del Comtat. A self-questionnaire sent this followed an interview with doctor.Five hundred forty-eight were interviewed....
Epidemiological studies of the risk factors cerebrovascular disease are great interest, particularly identification which may be modified. Previous carried out in Alcoi region Alicante province, showed a high prevalence disease. The town Bañeres was therefore chosen for confirmation this data and frequency vascular factors.To compare group patients with remainder population interviewed.In door-to-door study 1,832 people were interviewed as part Project. aged over 45 years filled...
Abstract Background : Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective this study is to analyze the selective involvement different cognitive domains, it impacts on quality life and possible existence related biomarkers. Methods Cross-sectional patients who survived with consecutively recruited from 13 neurology services in Spain between 90 120...