A5100764073- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Advanced Fiber Optic Sensors
- Advanced Fiber Laser Technologies
- Random lasers and scattering media
- Reproductive Physiology in Livestock
- Acute Ischemic Stroke Management
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Acupuncture Treatment Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Photonic Crystal and Fiber Optics
- Traditional Chinese Medicine Studies
- Inflammatory Bowel Disease
- Optical Coherence Tomography Applications
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Salivary Gland Disorders and Functions
- Acute Kidney Injury Research
- Neonatal and Maternal Infections
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
Anhui Medical University
2025
Weatherford College
2024
Nanjing University of Chinese Medicine
2023-2024
Nanjing Second Hospital
2024
Nanjing Medical University
2024
Tianjin University of Technology
2008-2023
Nagoya University
2022-2023
First Affiliated Hospital of Zhengzhou University
2015-2023
Zhengzhou People's Hospital
2012-2022
First Affiliated Hospital of Henan University
2022
Neutrophils can function and survive in injured infected tissues, where oxygen metabolic substrates are limited. Using radioactive flux assays LC-MS tracing with U-13C glucose, glutamine, pyruvate, we observe that neutrophils require the generation of intracellular glycogen stores by gluconeogenesis glycogenesis for effective survival bacterial killing. These adaptations dynamic, net increases observed following LPS challenge or altitude-induced hypoxia. from patients chronic obstructive...
Gram-positive bacterial pneumonia is a significant cause of hospitalization and death. Shortage good experimental model therapeutic targets hinders the cure acute lung injury (ALI). This study has established mouse ALI using bacteria Lactobacillus casie cell wall extracts (LCWE) identified key regulator NLRP3. We show that LCWE induces TNF, NF-κB signaling, so on pathways. Similar to lipopolysaccharide (LPS), infiltration CD11b-positive cells inflammation in lungs. also triggers inflammatory...
In this paper, we focus on fractional programming problems that minimize the ratio of two indefinite quadratic functions subject to constraints. Utilizing relationship between and parametric programming, transform original problem into a univariate nonlinear equation. To evaluate function in equation, need solve minimizing nonconvex This is commonly called Celis-Dennis-Tapia (CDT) subproblem, which arises some trust region algorithms for equality constrained optimization. outer iterations...
The purpose of this study was to investigate the marital adjustment patients with Crohn's disease and their spouses, analyze its influencing factors. It lays investigation foundation for follow-up binary spouses. Using convenience sampling, 177 pairs spouses from a tertiary hospital in Nanjing, China were selected. With face-to-face electronic questionnaires survey patient spouse, contents include Lock-Wollance Marriage Adjustment Test, Subjective Well-Being Scale Chinese Citizens, Couple...
A multi-wavelength switchable random fibre laser based on a double Sagnac-loop filter is proposed. The threshold of 27 mW and the slope efficiency total power output to pump about 0.04%. In experiment, stable outputs single-, dual-, tri- quad-wavelength channels are obtained by adjusting polarization controller at room temperature. wavelength positions tuneable within range 1556–1564 nm intervals between 2.5, 5 7.5 nm. Under 300 power, average intensity −24dBm achieved. Furthermore,...
What is known and objective Thiopurine methyltransferase (TPMT) enzyme an important component in the metabolism of azathioprine (AZA). Its mutation may lead to AZA-induced toxicity. The dysfunctional genetic variant TPMT *3C low frequency among Asians. Moreover, toxicity still occurs some patients with normal activity. This suggests that additional factors, including other variants, contribute such Recent studies described a strong association between NUDT15, gene mediates hydrolysis...
In female mammals, the abnormal apoptosis of ovarian granulosa cells (GCs) impairs follicular development and causes reproductive dysfunction. Many studies have indicated that FGFR1 gene PI3K signaling pathway p65 subunit transcription factor NF-κB may regulate proliferation GCs involved in development. However, little is known about whether regulates FGFR1, as well biological effects on survival porcine follicles GCs, we found were exclusively expressed follicles, mRNA protein levels...
The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosurgery and systemic treatment. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) could be effective on cerebral mutated NSCLC. However, which EGFR-TKIs more appropriate still unknown.We conducted a retrospective analysis advanced NSCLC patients EGFR targeted from...
Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are associated with significant morbidity and mortality. Among solid organ transplant recipients (SOTRs), clinical outcomes risk factors for death following such infections remain not well documented. A single-center retrospective study was performed. All SOTRs a CRKP infection at the First Affiliated Hospital of Zhengzhou University between 1 January 2018 31 December 2021 were included. Multivariable Cox regression...
Abstract Background In mammals, it is known that the estradiol-17β (E2) mainly synthetized in ovarian granulosa cells (GCs), and excessive apoptosis of GCs induces follicular atresia. Many studies have implicated essential role KISS1, with pro-synthetic effect E2 anti-apoptotic on GCs, mammalian folliculogenesis, several STAT4 potential binding sites were previously predicted promoter KISS1 pigs. However, biological effects molecular regulation between remained largely unknown. Methods Using...
SIRT6, a member of the yeast silent information regulator 2 (SIR2) family, possesses both robust ADP-ribosyltransferase activity and protein deacetylase depending on NAD+. It has been shown to maintain genomic stability telomere integrity, prevent age-related disorders premature ageing. However, mechanism by which SIRT6 overexpression affects cellular ageing is not well understood. In this study, we investigated effect cytotoxicity syndromes. A full-length cDNA porcine was inserted into...
Previous studies suggest that signal transducer and activator of transcription 3 (STAT3) CCAAT/enhancer binding protein beta (C/EBPβ) play an essential role in ovarian granulosa cells (GCs) for mammalian follicular development. Several C/EBPβ putative sites were previously predicted on the STAT3 promoter mammals. However, molecular regulation their effects cell proliferation apoptosis remain virtually unexplored GCs. Using porcine GCs as a model, 5′-deletion, luciferase report assay,...