A5011272768- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Neurological Complications and Syndromes
- Renal Transplantation Outcomes and Treatments
- Genetic and Kidney Cyst Diseases
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Abdominal vascular conditions and treatments
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Renal and Vascular Pathologies
- Ocular Oncology and Treatments
- Pancreatic and Hepatic Oncology Research
Singapore General Hospital
2013-2025
SingHealth
2021
Duke-NUS Medical School
2015-2020
National University Health System
2020
University College London
2008
Singapore National Eye Center
2008
Worthing Hospital
1994
Clear cell sarcoma of the kidney (CCSK) is a rare paediatric renal malignant tumour. The majority CCSKs have internal tandem duplications (ITDs) BCOR gene, whereas minority YWHAE-NUTM2 gene fusion. A third 'double-negative' (DN) category comprises with neither ITDs nor aim this study was to characterise 11 histologically diagnosed immunohistochemically (with CCND1, and CCNB3 stains) genetically.By next-generation sequencing, 10 cases (90.9%) had exon 15 ITDs, positive immunoreactivity being...
Alterations in epithelial mucin expression are associated with carcinogenesis, but there few data biliary tract cancer (BTC). In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as sensitive serological marker for BTC. We assessed (i) prospectively collected bile serum specimens from 72 patients obstruction (39 BTC) by real-time reverse transcriptase–PCR (qPCR) western blot analysis, (ii) 79 archived tissues (69 immunohistochemistry....
Abstract Background Epstein–Barr virus‐associated smooth muscle tumors ( EBV SMT ) in adult kidney transplant recipients KTR are rare. The aims of this study to document the clinical features, types treatment given, and outcomes with our institution. Methods Sixteen patients were identified from institution's databases. Patients' survival, tumor outcome, graft survival compared between who remained on cyclosporine‐based immunosuppressant those converted sirolimus‐based therapy. Results...
The pattern of glomerulonephritis (GN) in Singapore is compared with that 19 other countries to review changing trends the evolution GN Asian, Eastern, and Western countries.Three thousand two hundred eighty-nine renal biopsies were reviewed countries.IgA nephritis on decline many countries, including Singapore, though it still remains commonest Singapore. Membranous if used be more frequently present has also declined continues a rising trend such as China. Worldwide, frequency focal...
Abstract Objectives The Kleefstra syndrome spectrum (KSS) is a group of neurodevelopmental disorders characterized by intellectual disability, behavioral disorders, growth and delay, facial dysmorphism neurological deficits. 2 (KLEFS2) part KSS due to heterozygous loss-of-function variants in the KMT2 C gene. We report long-term clinical course multi-organ manifestations patient with KLEFS2 caused novel pathogenic variant . Methods A phenotype developed proteinuria progressive kidney...
Pathological diagnosis of clear cell sarcoma the kidney (CCSK) is challenging as it resembles blastemal Wilms tumor (WT) and other pediatric sarcomas, does not have any distinctive immunophenotype. The YWHAE-FAM22 translocation t(10;17)(q22;p13) has been reported in a subset CCSK. This also occurs high-grade endometrial sarcoma, which associated with cyclin D1 overexpression. Hence we seek to determine status immunoreactivity series local CCSK cases. Of 8 cases from 7 patients identified, no...
Abstract Multinational studies have reported monogenic etiologies in 25%–30% of children with steroid‐resistant nephrotic syndrome. Such large are lacking Asia. We established Deciphering Diversities: Renal Asian Genetics Network (DRAGoN) and aimed to describe the genetic clinical spectrums Asians. prospectively studied a cohort 183 probands suspected glomerulopathies from South Southeast Asia, whom 17% had positive family history. Using multi‐gene panel sequencing, we detected pathogenic...
Objective To determine the efficacy of CXCL5 administration in lupus‐prone MRL/ lpr (Fas ) mice and elucidate its working mechanisms. Methods expression blood (obtained from SLE patients Fas mice) major internal organs was examined by Luminex, real‐time polymerase chain reaction, immunofluorescent staining analyses. Pharmacokinetic studies were performed healthy Institute Cancer Research mice. Efficacy demonstrated mice, mechanism treatment elucidated flow cytometry, RNA sequencing. Results...
Aim . To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease. Methods In a cohort 9 recruited consecutively at disease onset, we characterized (1) immune the using immunohistochemistry (2) flow cytometry. As an exploratory analysis, association numbers percentages both kidney-infiltrating kidney outcomes including deterioration function proteinuria, as well time to complete clinical remission up 48...
Diabetes mellitus is characterized by chronic inflammation and increased risk of infections, particularly tissues exposed to the external environment. However, causal molecular mechanisms that affect immune cells their functions in diabetes are unclear. Here we show, transcript protein analyses, signatures glucose-induced tissue damage, inflammation, oxidative stress, dysregulated expression multiple inflammation- immunity-related molecules diabetic kidneys compared with non-diabetic...
Benign tumours of the extrahepatic bile ducts are rare, mostly occurring in common duct and hepatic ducts. Solitary papillomas occur mainly gallbladder or at ampulla Vater. Tumours cystic extremely we unaware any reports solitary papilloma duct. Such a case 72-year-old woman is presented.
Synchronous cystic tumors of the pancreas are rarely reported in literature. We report an unusual case synchronous pancreatic serous tumor (SCT) and intraductal mucinous (IPMT) with concomitant gastric carcinoma. This study highlights importance careful intra-operative pathologic examination for neoplasms.
To compare the differential immune T cell subset com
Although the use of current immunosuppressive regimens has significantly improved outcomes autoimmune renal diseases, infectious complications remain an important clinical concern. Cytomegalovirus (CMV) infection been shown to be one major causes mortality in this group patients. We report two cases vasculitis (Granulomatosis with polyangiitis (GPA) and microscopic (MPA)) that developed into severe gastrointestinal CMV disease manifested massive small bowel bleeding, resulting eventual fatal...
This review of 3,289 native kidney biopsies over the past four decades in Singapore documents changing pattern biopsy-proven glomerulonephritis (GN)from that a third world country to developed nation. In 1st decade, mesangial proliferative GN was most common form primary GN, similar Asian region. 2nd percentage decreased, but membranous became more common, as seen China and Thailand. 3rd focal segmental glomerulosclerosis (FSGS) nephropathy continued rise, it only recently, 4th FSGS...
Background: Mazabraud's syndrome was first described, by Mazabraud et al. as a rare disease, associated with single or multiple intramuscular myxomas monostotic polyostotic forms of fibrous dyplasia, Purpose: Reports this is and usually myoxomatas. The authors would want to report the occurrence case hamartoma basis for record future studies. Method: An adult male came institution 4 years ago complaining right unilateral proptosis that he had since childhood. However, progressed in month's...
This study on the prevalence of diabetic nephropathy (DN) and coexistence non-diabetic renal disease (NDRD) in a cohort 255 non-insulin-dependent diabetes mellitus (NIDDM) patients aims to determine value performing biopsies these elucidate factors which could affect their progression end-stage (ESRD).Among NIDDM patients, 93 had DN alone, 69 NDRD remaining plus (mixed group). The indications for biopsy were based clinical suspicion superimposed NDRD, including heavy or rapidly increasing...