A5009947778- Malaria Research and Control
- Remote Sensing in Agriculture
- Congenital Heart Disease Studies
- Mosquito-borne diseases and control
- Remote Sensing and LiDAR Applications
- Invertebrate Immune Response Mechanisms
- Land Use and Ecosystem Services
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Forest ecology and management
- Trypanosoma species research and implications
- Tissue Engineering and Regenerative Medicine
- Virology and Viral Diseases
- Virus-based gene therapy research
- Tracheal and airway disorders
- Vector-borne infectious diseases
- Cryospheric studies and observations
- Species Distribution and Climate Change
- Cardiovascular Issues in Pregnancy
- Remote-Sensing Image Classification
- Urban Green Space and Health
- Membrane Separation Technologies
- Water Treatment and Disinfection
- RNA Interference and Gene Delivery
- Wildlife-Road Interactions and Conservation
China Medical University
2015-2025
Hong Kong Polytechnic University
2019-2024
Southwest Jiaotong University
2024
Kunming Medical University
2012-2024
China Three Gorges University
2023
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
University of South Florida
2021
Creative Commons
2019
Pennsylvania State University
2016-2018
Artemisinin resistance has emerged in Southeast Asia, endangering the substantial progress malaria elimination worldwide. It is associated with mutations PfK13 protein, but how mediates artemisinin not completely understood. Here we used a new antibody against to show that protein expressed all stages of asexual intraerythrocytic cycle as well gametocytes and partially localized endoplasmic reticulum. By introducing four into 3D7 strain reverting these field parasite isolates, determined...
In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration leukocytes parasite-infected RBCs in the brain. this study, we explored effect vitamin D (VD; cholecalciferol) treatment on host immunity outcome ECM C57BL/6 mice during Plasmodium berghei ANKA (PbA) infection. We observed that oral administration VD both before after PbA infection completely protected from ECM. significantly dampened inducible...
With the emergence of new types data (e.g. social media data) and cutting-edge computer technology Natural Language Processing), shortcomings traditional methods (subjective objective ways) for detecting urban livability can be overcome by an integrated approach. This study aims to develop a comprehensive approach measure based on statistic data, geo-data points interest), questionnaires survey, (Instagram), from both subjective angles. Hong Kong, as city with high level urbanization...
Abstract Background Age-related diminished ovarian reserve (AR-DOR) reduced the quality of oocytes, resulting in decreased female fertility. Aging is tightly related to abnormal distribution and function mitochondria, while mitophagy a major process maintain normal quantity mitochondria cells, especially oocytes which containing large number meet demand energy production during oocyte maturation subsequent embryonic development. Ampk/FoxO3a signaling crucial regulation mitophagy. It reported...
Background Plasmodium vivax is a major cause of malaria, particularly outside Africa, necessitating effective strategies for public health management. Transmission-blocking vaccines (TBVs) have shown the potential to inhibit malaria transmission by targeting antigens expressed in sexual-stage parasites. Pbg37, conserved protein sexual stages from gametocyte ookinete rodent parasite P. berghei , viable target TBV development. Methods and findings In this study, we constructed transgenic...
Falcipain-2a ([FP2a] PF3D7_1115700) is a Plasmodium falciparum cysteine protease and hemoglobinase. Functional FP2a required for potent activity of artemisinin, in vitro selection artemisinin resistance selected an nonsense mutation. To investigate associations between polymorphisms to characterize the diversity enzyme parasites from China-Myanmar border, we sequenced full-length gene 140 P isolates collected during 2004–2011. The were grouped into 8 different haplotype groups. Haplotype...
Landscape ecological risk assessment (LERA) evaluates different types of potential environmental impacts and their cumulative effects, thereby providing policy insights for sustainable regional land-use ecosystem management. In a departure from existing literature that heavily relies on low-resolution data LERA at provincial or municipal scales, this study applies high-resolution to relatively small research area (county). addition, modifies the evaluation units equal-sized grids watersheds...
Obtaining an accurate diagnosis of fetal aortic arch anomalies is often difficult with traditional two-dimensional (2D) sonography. Thus, the aim this study was to assess value three-dimensional (3D) sonography spatiotemporal image correlation for diagnosing using a novel algorithm 3D volume analysis.Two-dimensional and echocardiographic data from 300 normal fetuses 30 were retrospectively reviewed. Grayscale high-definition flow imaging available 2D echocardiography. Three-dimensional...
The widely distributed lakes, as one of the major components inland water system, are primary available freshwater resources on earth and sensitive to accelerated climate change extensive human activities. Lakes play an important role in terrestrial cycle biogeochemical substantially influence health humans living surrounding areas. Given importance lakes ecosystem, long-term monitoring dynamic changes has theoretical practical significance. Here, we extracted body information monitored...
Artemisinin resistance in Plasmodium falciparum has emerged as a major threat for malaria control and elimination worldwide. Mutations the Kelch propeller domain of PfK13 are only known molecular markers artemisinin this parasite. Over 100 non-synonymous mutations have been identified from various endemic regions. This study aimed to investigate genetic diversity PvK12, vivax ortholog PfK13, parasite populations Southeast Asia, where P. emerged.The PvK12 sequences 120 isolates collected...
In the pursuit of sustainable urbanization, Bike-Sharing Services (BSS) emerge as a pivotal instrument for promoting green, low-carbon transit. While BSS is often commended its environmental benefits, we offer more nuanced analysis that elucidates previously neglected aspects. Through Dominant Travel Distance Model (DTDM), evaluate potential to replace other transportation modes specific journey based on travel distance. Utilizing Multiscale Geographically Weighted Regression (MGWR),...
Transmission-blocking vaccines (TBVs) are a promising strategy for malaria control and elimination. However, candidate TBV antigens currently limited, highlighting the urgency of identifying new development. Using combination bioinformatic analysis functional studies in rodent model Plasmodium berghei, we identified conserved protein PbPH (PBANKA_041720) containing pleckstrin homology (PH) domain. The expression was detected by Western blot indirect immunofluorescence assay (IFA). function...
Abstract Background The malaria elimination plan of the Greater Mekong Subregion (GMS) is jeopardized by increasing number Plasmodium vivax infections and emergence parasite strains with reduced susceptibility to frontline drug treatment chloroquine/primaquine. This study aimed determine evolution P. multidrug resistance 1 ( Pvmdr1 ) gene in parasites isolated from China–Myanmar border area during major phase elimination. Methods Clinical isolates were collected 275 patients 2008, 2012–2013...
Information about tree species plays a pivotal role in sustainable forest management. Light detection and ranging (LiDAR) technology has demonstrated its potential to obtain information using the structural features of trees. Several studies have explored properties boreal or temperate trees from terrestrial laser scanning (TLS) data applied them classification, but study tropical for classification is rare. Compared conventional static TLS, handheld (HLS) able effectively capture point...
The male gamete fertilization factor P48/45 in malaria parasites is a prime transmission-blocking vaccine (TBV) candidate. Efforts to develop antimalarial vaccines are often thwarted by genetic diversity of the target antigens. Here we evaluated Pvs48/45 gene global Plasmodium vivax populations. We determined 200 sequences collected from temperate and subtropical parasite populations China. Population evolutionary analyses were performed determine levels diversity, potential signature...
Transmission-blocking vaccines (TBVs) interrupting malaria transmission are an integrated tool for eradication. We characterized a sexual-stage-specific gene (PBANKA_060330) from Plasmodium berghei and studied its potential use as TBV. This gene, referred to pbg37, encodes protein of 37 kDa with signal peptide multiple transmembrane domains is preferentially expressed in gametocytes. A recombinant Pbg37 (rPbg37) targeting the N-terminal 63 amino acids (amino 26 88) bacteria elicited strong...
Abstract Background Since helminths and malaria parasites are often co-endemic, it is important to clarify the immunoregulatory mechanism that occurs during process of co-infection. A previous study confirmed dendritic cells (DCs) involved in establishment regulation T-cell-mediated immune response infection. In current study, distinct profiles for splenic DCs regulatory T cell (Treg) responses were assessed evaluate effects a pre-existing Schistosoma japonicum infection on Methods Malaria...
Malaria parasites in different areas where malaria is endemic display levels of resistance to antimalarial drugs as the result varied drug use histories. To provide updated knowledge sensitivities during elimination phase Southeast Asia, an epicenter multidrug resistance, we determined vitro susceptibilities culture-adapted Plasmodium falciparum isolates from two eastern border regions (Wa and Kachin) Myanmar 10 drugs. Despite their close proximity, Kachin displayed higher 50% inhibitory...