Semaglutide (GLP-1 agonist) was approved for treating obesity. Although the effects on weight loss and metabolism are known, responses of adipocytes to semaglutide yet limited. C57BL/6 male mice (n = 20/group) were fed a control diet (C) or high-fat (HF) 16 weeks then separated into four groups 10/group) an additional weeks: C, C semaglutide, HF, HF semaglutide. Epididymal white adipose tissue (eWAT) subcutaneous (sWAT) fat pads studied with biochemistry, immunohistochemistry/fluorescence,...

Background Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines glucose-insulin homeostasis dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts weight loss regain, a phenomenon known cycling (WC). Methods In this work we studied the effects WC on feed efficiency, blood lipids, carbohydrate metabolism, adiposity inflammatory markers in C57BL/6 male mice that two or three...

To evaluate the pleiotropic effects of empagliflozin in liver through lipogenesis, beta-oxidation, and endoplasmic reticulum stress pathways. Male C57Bl/6 mice, 3 months age, received a control diet (C, 10% lipids, n = 20) or high-fat (HF, 50% for 10 weeks, after that, groups were subdivided to receive empagliflozin, during 5 weeks at dose mg/kg/day added diets, totalizing four groups: C, C-EMPA, HF, HF-EMPA. We performed biochemical analyzes, oral glucose tolerance test, homeostasis model...

Intermittent fasting (IF) is a nutritional intervention with significant metabolic effects on the liver that are not yet fully understood. The aim of this study was to investigate IF body mass, lipid profile, glucose metabolism, lipogenesis, β-oxidation, and inflammation.We used cellular molecular techniques 3-mo-old male C57 BL/6 mice were fed control (10% kcal fat), high-fat (HF; 50% or high-fructose (HFr; fructose) diets for 8 wk. Half animals submitted (1 d fed, 1 fast) an additional 4...

Changes in feeding habits are the primary environmental factors (though modifiable) commonly correlated with increase diseases such as obesity and associated comorbidities.

To assess the effects of peroxisome proliferator-activated receptor (PPAR) agonists on glucose tolerance and hepatic lipid metabolism in diet-induced obese mice. Male C57BL/6 mice received a standard chow diet (SC, 10% energy as lipids) or high-fat (HF, 50% for 10 weeks, after which treatment was initiated, forming groups: SC group, HF HF-BZ group (HF + bezafibrate, pan-PPAR agonist), HF-WY WY-14643, PPARalpha agonist) HF-GW GW1929, PPARgamma agonist). Treatments lasted four weeks. Insulin...

Studies show that the continuous consumption of fructose can lead to nonalcoholic fatty liver disease (NAFLD) and steatohepatitis. We aimed investigate role Metformin in an animal model injury caused by intake, focusing on molecular markers lipogenesis, beta-oxidation, antioxidant defenses. Male three months old C57BL/6 mice were divided into control group (C) (F, 47% fructose), maintained for ten weeks. After, groups received or vehicle a further eight weeks: (C), + (CM), (F), (FM)....

Intermittent fasting (IF) sets the preference for fats as fuel and is linked to beneficial metabolic outcomes; however, effects in renin-angiotensin system (RAS) heart remains be determined. We hypothesized that IF improves blood pressure lipid profiles due a less activated local RAS left ventricle of mice, irrespective dietary scheme. This study aimed evaluate intermittent on cardiovascular parameters (LV) mice fed either high-fat (HF) or high-fructose diet (HFru). Metabolic alterations...

Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of adult population in Western world.This condition a major cause cardiovascular blindness, renal failure, and amputations, with increasing prevalence worldwide.The influence obesity on type risk determined by degree body fat localization, insulin resistance (IR) being main link between these diseases.Experimental studies have shown that dietary factors, particularly lipids, are strongly...

Obesity has been associated with hepatic overexpression of the renin-angiotensin system (RAS).To evaluate action two angiotensin II (ANGII) receptor blockers (losartan or telmisartan) on modulation local RAS and resulting metabolic effects in a diet-induced obesity murine model.Twenty C57BL/6 mice were randomly divided into nutritional groups for 10 wk: control group (C, n = 5, 10% energy as fat) high-fat (HF, 15, 50% fat). After treatment started, HF was three groups: untreated (n 5),...

Weight cycling (WC) is frequent in obesity treatment. We evaluated the degree of regression liver damage WC.C57BL/6 male mice received standard chow (SC, 10% energy from lipids) or high-fat diet (HF, 60% for 6 months (SC6 HF6) a that alternated every 2 (SC2/HF2/SC2 HF2/SC2/HF2).The body mass gain followed HF intake and induced WC animals. The alanine aminotransferase, triglyceride cholesterol levels were higher groups receiving any period. plasma insulin glucose highest HF6 HF2/SC2/HF2...

Aim The aim of this study was to investigate the effects rosuvastatin in a model diet‐induced obesity and non‐alcoholic fatty liver disease, with attention activation hepatic stellate cells (HSCs). Method Male C57BL/6 mice received control diet (C; 10% energy as lipids) or high‐fat (HF; 50% for 12 weeks, followed by 7 weeks treatment. Group CR + rosuvastatin; group HFR rosuvastatin. Results HF showed higher insulin, total cholesterol, triacylglycerol, leptin levels than C group, all which...

El consumo de fructosa ha aumentado en los últimos 50 años por la incorporación a dieta jarabe maíz alto (JMAF), presente productos industrializados, como las bebidas azucaradas. Se puede asociar ingesta altas concentraciones con el aumento obesidad y trastornos metabólicos. La fructosa, un azúcar natural que se encuentra muchas frutas, consume cantidades significativas dietas occidentales. En iguales, es más dulce glucosa o sacarosa y, lo tanto, usa comúnmente edulcorante. Debido al...

Aims. The cardiobenefits of empagliflozin are multidimensional, and some mechanisms still unclear. aim the present study was to evaluate effect treatment with on biometric parameters gene expression in local cardiac RAS, oxidative stress, endoplasmic reticulum pathways a mouse model. Main Methods. Forty male C57BL/6 mice were fed control (C) or high-fat (HF) diets for 10 weeks. After that, groups redistributed according empagliflozin—CE HFE. administered via food 5 weeks (10 mg/kg/day). We...

Scope To analyze the effects of fexaramine (FEX), as an intestinal FXR agonist, on modulation microbiota and ileum mice fed a high‐fat (HF) diet. Methods results Three‐month‐old C57Bl/6 male are divided into two groups received control (C, 10% energy from lipids) or HF (50% diet for 12 weeks. They subdivided C, C + FEX, HF, FEX groups. is administered (FEX‐5 mg kg −1 ) via orogastric gavage three Body mass (BM), glucose metabolism, qPCR 16S rRNA gene expression, bile acids (BAs), tight...

To investigate the effects of linagliptin treatment on hepatic energy metabolism and ER stress in high-fat-fed C57BL/6 mice.Forty male mice, three months age, received a control diet (C, 10% lipids as energy, n = 20) or high-fat (HF, 50% for 10 weeks. The groups were randomly subdivided into four to receive linagliptin, five weeks, at dose 30 mg/kg/day added diets: C, C-L, HF, HF-L groups.The HF group showed higher body mass, total cholesterol levels triacylglycerol than C group, all which...

Both Hepatic Lipogenesis and Beta-Oxidation are Altered in Offspring of Mothers Fed a High-Fat Diet the First Two Generations (F1 F2) La Lipogénesis Hepática y la Beta-Oxidación están Alteradas en las Crías de Madres Alimentadas con una

RESUMEN Uno de los endulzantes más comúnmente utilizado es la fructosa.La fructosa directamente metabolizada en el hígado y se puede transformar glucosa, posteriormente almacenada como glicógeno constituyéndose una fuente energía para hepatocitos.Todo exceso convierte lípidos ejerciendo un efecto tóxico sobre hígado, similar al producido por alcohol, pudiendo provocar graso no alcohólico (NAFLD).El objetivo esta revisión reunir hallazgos recientes relación ingesta altas concentraciones su con NAFLD.