A5014399937- Colorectal Cancer Surgical Treatments
- Hippo pathway signaling and YAP/TAZ
- Aortic aneurysm repair treatments
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Autophagy in Disease and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Diverticular Disease and Complications
- Aortic Disease and Treatment Approaches
- Psoriasis: Treatment and Pathogenesis
- Histone Deacetylase Inhibitors Research
- Hormonal and reproductive studies
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- ATP Synthase and ATPases Research
- Hormonal Regulation and Hypertension
- Genetic Associations and Epidemiology
- Vascular Procedures and Complications
- Colorectal Cancer Screening and Detection
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
- Macrophage Migration Inhibitory Factor
- Aerogels and thermal insulation
- Cancer, Stress, Anesthesia, and Immune Response
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Chongqing Medical University
2021-2024
Chongqing University
2022
Chongqing Three Gorges University
2022
The first-line anticancer agent oxaliplatin (OXL) is the preferred drug for treating colorectal cancer (CRC); however, development of resistance common in patients treated with OXL, which considerably reduces efficacy OXL-based regimens. By performing genome-wide CRISPR/Cas9 library knockdown screening, we found that mitochondrial elongation factor 2 (MIEF2) was among top candidate genes. OXL-resistant cell lines and organoids developed present study showed stable but low expression MIEF2....
Osteosarcoma is the most prevalent form of primary bone malignancy affecting adolescents. Secretion-associated Ras-related GTPase 1A (SAR1A) a key regulator endoplasmic reticulum (ER) homeostasis, but its role as osteosarcoma metastasis has yet to be clarified. Bioinformatics analyses revealed SAR1A and RHOA upregulated in patients, with upregulation these genes being associated poor 5-year metastasis-free survival rates. In addition, was highly positively correlated. Immunohistochemical...
Purpose: Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease that often results in high mortality due to sudden rupture. This paper aims explore potential molecular mechanisms and effective targeted therapies prevent delay AAA Methods: We downloaded two microarray datasets (GSE98278 GSE17901) from the Gene Expression Omnibus (GEO) database. Differential analysis single-sample gene set enrichment (ssGSEA) of hypoxia scores were performed on 48 patients GSE98278. identified...
<title>Abstract</title> Psoriasis, like Crohn's Disease is a lasting inflammatory condition with complex mix of genetic and immune factors. It brings challenges to patients worldwide. This research delves into their connection by using RNA sequencing techniques gene expression analysis uncover pathways. emphasizes the significance NAMPT as influencing how they regulate responses disease development. The study sheds light on interplay among psoriasis merging datasets. provides perspectives,...
The aim of this study was to explore the genetic effects hormones modulated through pituitary-thyroid/adrenal/gonadal axis on risk developing venous thromboembolism (VTE) and investigate potentially causal relationships between them.
For laparoscopic right hemicolectomy, the intermediate approach is commonly employed. However, this possesses several disadvantages. In study, we compare priority access to small bowel mesentery and approach.The clinical data of 196 patients admitted First Hospital Chongqing Medical University for hemicolectomy from January 2019 2022 were retrospectively collected divided into mesenteric traditional groups. The operative time, intraoperative bleeding, number lymph node dissection,...
BACKGROUND Dopamine and cyclic adenosine monophosphate (cAMP)-regulated phosphoprotein with an apparent Mr of 32000 (DARPP-32) is a protein that involved in regulating dopamine cAMP signaling pathways the brain. However, recent studies have shown DARPP-32 also expressed other tissues, including colorectal cancer (CRC), where its function not well understood. AIM To explore effect on CRC progression. METHODS The expression levels were assessed tissues using both quantitative polymerase chain...
Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein (DARPP-32) is overexpressed during colorectal cancer. Since the effect of DARPP-32 on neoplasia unknown, this study combined bioinformatics analysis, quantitative real-time PCR, western blotting, tissue microarrays, a variety in vitro vivo functional tests to investigate effect. We found that was frequently upregulated cancer associated with abnormal clinicopathological features Overexpression shown promote progression....
Background This case report demonstrates the efficacy of total neoadjuvant therapy (TNT) based on pathological complete response (PCR). We also discuss surgical approach to preserving anus and its perioperative management. Case presentaion The patient was a 26-year-old woman, with blood in stool thinning for over two months. Preoperative examination revealed locally advanced rectal cancer invading left anal raphe enlarged lymph nodes adjacent internal iliac vessels. lesion preoperatively...
Lymph node ratio has garnered increasing attention as a prognostic marker for rectal cancer; however, few studies have investigated the relationship between lymph and cancer recurrence. Additionally, Carbon Nanoparticle tracking is safe effective strategy locating tumors nodes. However, no reported Nanoparticles recurrence.Patients with stage III who underwent radical resection January 2016 2020 were analyzed. The primary outcome was tumor 269 patients included in this study. effects of...
Abstract Background: Osteosarcoma (OS) is the prevalent form of primary bone cancer among adolescents, but 5-year overall survival rate for patients with a metastatic or recurrent OS under 20%. Angio-associated migratory cell protein (AAMP) known to be key regulator cellular migration, yet its role in context metastasis has firmly established. Methods: Bioinformatics analyses were used explore association between AAMP and YAP expression prognosis patients, evaluate differences OS, pulmonary...