A5022845624- Wound Healing and Treatments
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Tissue Engineering and Regenerative Medicine
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Lymphatic System and Diseases
- Virology and Viral Diseases
- Health and Medical Research Impacts
- Animal Virus Infections Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Bacteriophages and microbial interactions
- Diversity and Career in Medicine
- Viral Infectious Diseases and Gene Expression in Insects
- Hair Growth and Disorders
- Proteoglycans and glycosaminoglycans research
- Connective tissue disorders research
- Cancer Research and Treatments
- Tendon Structure and Treatment
- Skin Protection and Aging
- Health and Lifestyle Studies
- vaccines and immunoinformatics approaches
- Venous Thromboembolism Diagnosis and Management
- Viral gastroenteritis research and epidemiology
- Pressure Ulcer Prevention and Management
ID Genomics (United States)
2024-2025
Baylor College of Medicine
2016-2022
Texas Children's Hospital
2016-2022
Cincinnati Children's Hospital Medical Center
2014-2015
Tulane University
2014
The aim of this study was to examine the challenges confronting surgeons performing basic science research in today's academic surgery environment.Multiple studies have identified surgeon-scientists and impacting their ability be successful. Although these threats been known for decades, downward trend number successful continues. Clinical demands, funding challenges, other factors play important roles, but a rigorous analysis experiences regarding issues has not previously performed.An...
Abstract Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL‐10), an anti‐inflammatory cytokine that primarily signals via STAT3, has been shown drive EPC recruitment injured tissues. Our previous work demonstrated overexpression of IL‐10 in dermal wounds promotes regenerative repair STAT3‐dependent regulation fibroblast‐specific hyaluronan synthesis. However, IL‐10's role specific mode action on recruitment,...
The cytokine IL-10 has potent antifibrotic effects in models of adult fibrosis, but the mechanisms action are unclear. Here, we report a novel finding that triggers signal transducer and activator transcription 3(STAT3)–dependent signaling pathway regulates hyaluronan (HA) metabolism drives fibroblasts to synthesize an HA-rich pericellular matrix, which mimics fetal regenerative wound healing phenotype with reduced fibrosis. By using cre-lox-mediated novel, inducible, fibroblast-,...
Abstract Introduction: Oncolytic viral therapies (OVTs) have shown promise in cancer treatment, though efficacy and selectivity challenges remain. HGI627 is an engineered vesicular stomatitis virus (VSV) featuring a synthetic glycoprotein retargeted to glypican-3 (GPC3) beta-catenin (CTNNB1)-dependent aptazyme as genetic ON switch. This dual targeting strategy enhances specificity liver cells. Methods: was constructed rescued using virology platform [Moles et al., Viruses 2024], titers were...
ABSTRACT Reduced mobilization of endothelial progenitor cells (EPCs) from the bone marrow (BM) and impaired EPC recruitment into wound represent a fundamental deficiency in chronic ulcers. However, mechanistic understanding role BM‐derived EPCs cutaneous neovascularization healing remains incomplete, which impedes development EPC‐based therapies. The objective this study was to determine both under normal conditions using single (EPC) or double‐deficiency (EPC + diabetes) models healing....
Abstract Background: Humane Genomics is pioneering multi-factored authenticated oncolytic virotherapy (OVT) using glycoprotein receptor matching and aptazyme technology to positively control replication in cytoplasm. Using VSV as a platform the OVTs show excellent safety remain highly lytic. Sindbis virus was mutated eliminate natural infectivity retargeted GPC3 with codon optimized nanobody. An used regulate viral replication. As far we are aware, this first report of functional ON switch...
Vesicular stomatitis virus (VSV) is a prototype RNA that has been instrumental in advancing our understanding of viral molecular biology and applications vaccine development, cancer therapy, antiviral screening, more. Current VSV genome plasmids for purchase or contract services provide limited options modification, restricted to predefined cloning sites insert locations. Improved methods tools engineer will unlock further insights long-standing virology questions new opportunities...
Vesicular stomatitis virus (VSV) is a prototype RNA that has been instrumental in advancing our understanding of viral molecular biology and applications vaccine development, cancer therapy, antiviral screening, more. Current VSV genome plasmids for purchase or contract services provide limited options modification, restricted to predefined cloning sites insert locations. Improved methods tools engineer will unlock further insights into long-standing virology questions new opportunities...
Abstract Introduction: Humane Genomics has developed a platform to make artificial oncolytic viruses with unprecedented selectivity and efficiency. The is based on Vesicular Stomatitis Virus (VSV), which several ideal properties (highly oncolytic, non-pathogenic, small genome that’s well understood easily modified). Here we present the development of HG001, our first therapy for treatment liver cancer. Methods: Genome design HG001 was completed using proprietary software. virus designed GPC3...
Abstract Evidence from prior studies of cutaneous trauma, burns, and chronic diabetic wound repair demonstrates that endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, anti-inflammatory reactions, tissue regeneration, remodeling. We have shown IL-10, a potent cytokine, promotes regenerative in an adult model dermal scar formation via the regulation fibroblast-specific hyaluronan synthesis STAT3 dependent manner. While it is known IL-10 drives EPC recruitment...