A5013380798- Enzyme Catalysis and Immobilization
- Photosynthetic Processes and Mechanisms
- Advanced Nanomaterials in Catalysis
- Synthesis and Catalytic Reactions
- Electrochemical sensors and biosensors
- Sulfur-Based Synthesis Techniques
- Advanced Photocatalysis Techniques
- Porphyrin Metabolism and Disorders
- Metalloenzymes and iron-sulfur proteins
- Photoreceptor and optogenetics research
- Porphyrin and Phthalocyanine Chemistry
- Biochemical and Molecular Research
- Chemical Synthesis and Reactions
- Amino Acid Enzymes and Metabolism
- Biofuel production and bioconversion
- CO2 Reduction Techniques and Catalysts
- Synthesis and Properties of Aromatic Compounds
- Microbial Fuel Cells and Bioremediation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Luminescence and Fluorescent Materials
- Algal biology and biofuel production
- Microbial Metabolic Engineering and Bioproduction
- Advanced biosensing and bioanalysis techniques
BioTechMed-Graz
2018-2024
University of Graz
2018-2024
Nawi Graz
2021-2023
Abstract Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare visible‐light photocatalysis. Here we show that redox potential carbon nitride photocatalyst (CN‐OA‐m) can be tuned by changing irradiation wavelength to generate electron holes different oxidation potentials. This tuning was key realizing photo‐chemo‐enzymatic cascades give either ( S )‐ or R )‐enantiomer phenylethanol. In combination an unspecific peroxygenase from...
Abstract The concurrent operation of chemical and biocatalytic reactions in one pot is still a challenging task, and, particular for photocatalysts, examples besides simple cofactor recycling systems are rare. However, especially due to the complementary chemistry that two fields catalysis promote, their combination has potential unlock intriguing, unprecedented overall reactivities. Herein we demonstrate reduction photocatalytic oxidation process. Specifically, enantioselective sulfoxide...
Abstract Photobiocatalysis is an alternative approach in synthesis that has received much attention the recent years. Due to youth of topic, only few reactor systems are commercially available. To allow a parallel parameter‐screening as often used optimization biocatalytic processes, photoreactor was developed can illuminate up 24 samples at well‐defined reaction conditions. The device‘s optical features and temperature regulation have been thoroughly characterized its application...
Abstract Many biocatalytic redox reactions depend on the cofactor NAD(P)H, which may be provided by dedicated recycling systems. Exploiting light and water for NADPH‐regeneration as it is performed, e.g. cyanobacteria, conceptually very appealing due to its high atom economy. However, current use of cyanobacteria limited, challenging time‐consuming heterologous enzyme expression in well limitations substrate or product transport through cell wall. Here we establish a transmembrane electron...
Abstract Synthetically established methods for methylation of phenols and demethylation methyl phenyl ethers rely in general on hazardous reagents or/and harsh reaction conditions are irreversible. Consequently, alternative regioselective the reversible formation breakage C-O-ether bonds to be performed under mild sustainable highly desired. Here we present a biocatalytic shuttle concept making use corrinoid-dependent transferases from anaerobic bacteria. The two-component enzymatic system...
Abstract Biocatalysis is increasingly used in combination with light to develop new and more sustainable synthetic methods. Thereby, mostly a chemical photocatalyst harvesting the energy combined an established enzymatic reaction, thus biocatalyst itself does not require for its specific reaction. Here we expand library of enzyme which requires natural namely light‐dependent protochlorophyllide oxidoreductase (LPOR). This catalyzes NADPH‐dependent reduction C=C N ‐heterocycle. Out five LPORs...
Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare visible-light photocatalysis. Here we show that redox potential carbon nitride photocatalyst (CN-OA-m) can be tuned by changing irradiation wavelength to generate electron holes different oxidation potentials. This tuning was key realizing photo-chemo-enzymatic cascades give either (
Isomerization is a fundamental reaction in chemistry. However, isomerization of phenyl methyl ethers has not been described yet. Using cobalamin-dependent transferase, reversible shuttle concept was investigated for catechol monomethyl ethers. The ether substituted derivatives successfully transferred onto the adjacent hydroxy moiety. For instance, biocatalyst transformed isovanillin to its regioisomer vanillin with significant regioisomeric excess (68% vanillin). To best our knowledge, by...
The concurrent operation of chemical and biocatalytic reactions in one pot is still a challenging task, and, particular for photocatalysts, examples besides simple cofactor recycling systems are rare. However, especially due to the complementary chemistry that two fields catalysis promote, their combination has potential unlock intriguing, unprecedented overall reactivities. Herein we demonstrate reduction photocatalytic oxidation process. Specifically, enantioselective sulfoxide using (
Abstract The synergistic combination of biocatalysis and photocatalysis is emerging as powerful tool for the development sustainable atom‐efficient synthetic concepts facilitating an enormous portfolio possible reactions which even goes beyond capabilities found in nature. Here, a cyclic deracemization process presented tailored synthesis optically pure sulfoxides are versatile structural motifs asymmetric well bioactive compounds. Enantioselective enzyme‐catalyzed reduction rac ‐sulfoxides...
Abstract Many biocatalytic redox reactions depend on the cofactor NAD(P)H, which may be provided by dedicated recycling systems. Exploiting light and water for NADPH‐regeneration as it is performed, e.g. cyanobacteria, conceptually very appealing due to its high atom economy. However, current use of cyanobacteria limited, challenging time‐consuming heterologous enzyme expression in well limitations substrate or product transport through cell wall. Here we establish a transmembrane electron...
Metal-Organic FrameworksIn their Communication on page 6920, Da-Huan Liu, Zhi-Yuan Gu et al. report ah ost-guest noncovalent strategy to tune the stacking modes of metal-organic framework nanosheets for alkane isomer separation.
The Cover Feature brings the enzyme named 'Light-Dependent Protochlorophyllide Oxidoreductases' (LPOR) into light. LPORs can be found in plants and other phototrophic organisms. It catalyzes light-driven reduction of a C=C double bond molecule pchlide to chlide, which is key intermediate biosynthesis chlorophyll. In their Full Paper, L. Schmermund et al. describe identification that also accept NADH as cofactor, unique since until now only NADPH-dependent have been described (Cover designed...
Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare visible-light photocatalysis. Here we show that redox potential carbon nitride photocatalyst (CN-OA-m) can be tuned by changing irradiation wavelength to generate electron holes different oxidation potentials. This tuning was key realizing photo-chemo-enzymatic cascades give either ( S )- or R )-enantiomer phenylethanol. In combination an unspecific peroxygenase from Agrocybe...
<a></a><a></a><a></a><a></a><a></a><a>Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare visible-light photocatalysis. Here we show that redox potential carbon nitride photocatalyst (CN-OA-m) can be tuned by changing irradiation wavelength to generate electron holes different oxidation potentials. This tuning was key realizing photo-chemo-enzymatic cascades give...