A5043216861- Diabetes and associated disorders
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Diabetes Management and Research
- Angiogenesis and VEGF in Cancer
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Bone health and treatments
- Curcumin's Biomedical Applications
- IL-33, ST2, and ILC Pathways
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Effects and risks of endocrine disrupting chemicals
- Biomarkers in Disease Mechanisms
- Parathyroid Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Radiopharmaceutical Chemistry and Applications
Poznan University of Medical Sciences
2008-2023
Introduction Autoimmune reactions in Graves' disease (GD) occur not only the thyroid gland, but also orbital connective tissue, eyelids, extraocular muscles. The occurrence of orbitopathy course GD is influenced by environmental factors, e.g. cigarette smoking. Objectives aim study was to analyze effect smoking on efficacy activity radioiodine(131I) therapy patients with GD. We studied influence and prednisone prophylaxis risk thyroid-associated ophthalmopathy (TAO) development after...
<b><i>Background/Aims:</i></b> Recent experimental research revealed that statins at low doses induce angiogenesis, which in turn may be related to the course of atherosclerosis. There are no clinical studies evaluating effect ‘low-dose' on serum levels angiogenesis regulators diabetic subjects. We aimed explain how modify concentrations two potent proangiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast (bFGF), patients with type 2...
T cells are among the earliest to infiltrate arterial intima during initial stages of atherosclerosis. Alterations in peripheral blood lymphocyte distribution might be associated with intensive lymphocytes extravasation and stimulation atherosclerotic plaque development. Epidemiological data reveal that short-term postprandial hyperglycemia is a significant risk factor for coronary heart disease. Using parameter indicates recently-past acute hyperglycemia, 1,5-anhydro-D-glucitol (1,5-AG),...
To evaluate the use of plasma 1,5-anhydro-d-glucitol (1,5-AG) level as a possible marker for glucose excursions in pregnant women with diabetes.The study group consisted 55 diabetes (gestational mellitus-GDM, n = 28 or pre-gestational mellitus -PGDM, 27), without hepatic renal insufficiency, gestational age range 5-38 weeks. In each patient, 24-h profile, glycated haemoglobin and 1,5-AG levels were measured. Mean blood (MBG) M-value (by Schlichtkrull) calculated. MBG, maximal daily glycaemia...
<b><i>Background:</i></b> The aim of this study was to assess the impact pharmacotherapy diabetes on atherosclerosis, as reflected in interleukin (IL)-1β, IL-6 and IL-10 serum levels. <b><i>Methods:</i></b> We studied patients with type 2 diabetes, treated metformin, insulin combined metformin conventional insulin. IL-1β, levels were assayed using BD™ Cytometric Bead Array. Multivariate analysis covariance performed exclude some metabolic...
The contemporary theory of the inflammatory-immunological pathomechanism atherosclerosis includes participation interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process. knowledge on direct effect hyperhomocysteinemia inflammatory-state-related is rather scarce. Our study first to account for effects secretion Il-10 RANTES vitro conditions. For purpose, human mitogen-stimulated peripheral blood mononuclear cells (PBMNCs) were cultured exposed at high concentrations....
Hyperproinsulinemia in type 2 diabetic subjects has recently been accepted as an independent cardiovascular risk factor. Moreover, it confirmed that high proinsulin concentrations stimulate amylin secretion by pancreatic beta-cells and amyloid accumulation within islets leading to impairment of secretory function. The association between sulfonylureas administration function beta-cells, especially concerning insulin precursor peptides, is not sufficiently elucidated. Preliminary studies our...
AimsThe aim of our study was to evaluate which the pharmacotherapeutic methods that are frequently used treat type 2 diabetes is associated with most beneficial profile in relation pro-atherogenic homocysteine levels.Patients and methodsWe measured serum level 182 patients treated metformin (89), insulin combination (31), receiving sulfonulureas (31) conventionally (31). The total levels were assayed using commercial kits (Axis® Human Homocysteine ELISA Kit, IBL). To exclude influence...
Modern treatment of glioblastoma multiforme (GBM) is based on neurosurgical methods combined with radiotherapy and chemotherapy. The prognosis for patients GBM extremely poor. Often, complete removal the tumor impossible it often recurs. Therefore, in addition to standard regimens, modern such as modulated electrohyperthermia, monoclonal antibodies individualised multimodal immunotherapy (IMI) vaccines oncolytic viruses are also used GBM. Radioiodine therapy (RIT) holds out hope an effective...
Gallotannins are class of hydrolyzable tannins consisting gallic acid and a sugar moiety. Currently, there is growing interest around possible neuroprotective effect this phytochemicals, which suggested to be result their active metabolites. Evidence from experimental studies has that tannin-rich plant preparations might effective at reversing neurodegenerative pathology age-related declines in neurocognitive performance. This mini-review summarizes, based on studies, current knowledge about...
Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value index distribution red blood cells volume (RDW) may be prognostic marker patients diagnosed with chronic heart failure (CHF). Hypothyroid present higher RDW values if compared to healthy controls. Taking into consideration that might both affected by thyroid status CHF, we decided determine effect concomitant hypothyroidism following radioiodine therapy...
The aim of this study was to investigate the influence statins on secretion angiogenesis mediators by peripheral blood mononuclear cells (PBMCs) derived from patients suffering type 2 diabetes. group comprised 30 participants and included: 10 statin-treated with diabetes, statin-free diabetic subjects, non-diabetic individuals. PBMCs isolated were cultured in vitro standard conditions an environment mimicking hyperglycemia. Culture supernatants evaluated for VEGF, MCP-1, Il-10, Il-12 flow...
Despite the increasing number of studies on molecular actions quercetin and curcumin, their anticancer efficacy, safety aspects chemopreventive action in ovarian cancer prophylaxis or treatment also potential sensitization to cytostatics used clinical practice remains still not clearly understood. Based basic we have summarized evidences for inhibitory activities several often studied plantorigin bio-active compounds (mostly curcumin) against cells proliferation, mechanisms as well strong...
Gallotannins are class of hydrolyzable tannins consisting gallic acid and a sugar moiety. Currently, there is growing interest around possible neuroprotective effect this phytochemicals, which suggested to be result their active metabolites. Evidence from experimental studies has that tannin‑rich plant preparations might effective at reversing neurodegenerative pathology age‑related declines in neurocognitive performance. This mini‑review summarizes, based on studies, current knowledge about...
Radioactive iodine therapy (RIT) is an effective, safe, and cheap method in benign malignant thyroid diseases. There still unresolved question of whether RIT treatment also plays a role the of, for example, breast cancer, lung or glioblastoma multiforme (GBM). These studies are currently being carried out rats combination with genes, but it may be interesting challenge to assess "pure" alone, thanks expression sodium iodide symporter (NIS), effective other organ nodules, both malignant....