A5048737171- Organic Electronics and Photovoltaics
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Organic Light-Emitting Diodes Research
- Conducting polymers and applications
- Perovskite Materials and Applications
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Crystallization and Solubility Studies
- Semiconductor materials and devices
- Synthesis and Biological Activity
- Neutropenia and Cancer Infections
- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- Supramolecular Chemistry and Complexes
- Natural Antidiabetic Agents Studies
- Advances in Cucurbitaceae Research
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Sesquiterpenes and Asteraceae Studies
- Advanced Sensor and Energy Harvesting Materials
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Organic and Molecular Conductors Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2024
Beijing University of Chinese Medicine
2024
Chinese Academy of Sciences
2016-2019
Beijing National Laboratory for Molecular Sciences
2016-2019
Center for Excellence in Education
2019
Institute of Chemistry
2016-2017
State Key Laboratory of Medicinal Chemical Biology
2014-2016
Nankai University
2013-2016
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2016
The diphenylethene moiety is a versatile building block that offers several chemically functionalizable sites, allowing easy modulation of electronic properties the resulting polymers and providing numerous opportunities for discovering related structure–property relationships. In this study, we report series difluorodiphenylethene-based copolymers with noncovalent conformational locks applications in polymer field-effect transistors. Different fluorination positions lead to different type...
β-Cyclodextrin modified camptothecin (CPT–CD) was synthesized through esterification reaction and "click chemistry" to greatly improve the solubility of CPT in aqueous solution, then, a supramolecular nanoparticle constructed by strong noncovalent interaction between β-cyclodextrin adamantane amphiphilic simply mixing CPT–CD hyaluronic acid (HA–ADA) together. The obtained had hydrophilic HA shell, which could target recognize receptors overexpressed on surface cancer cells, hydrophobic core,...
Highly coplanar bis(thiazol-2-yl)-diketopyrrolopyrrole based donor–acceptor copolymers were synthesized and their field-effect transistors exhibited ambipolar charge carrier transporting performance.
The performance of polymer field-effect transistors was enhanced by microstructure engineering through the use a bi-component solvent.
We designed and synthesized two donor–acceptor type conjugated polymers, the regioirregular polymer RI-PDPP-CNTVT-6 its regioregular counterpart RR-PDPP-CNTVT-6, based on diketopyrrolopyrrole (DPP) alkylated dithienylacrylonitrile (CNTVT) units. Among them, 2-decyltetradecyl side chain DPP acceptor unit hexyl CNTVT donor were used to ensure enough solubility for them. The backbone regioregularity was tune electronic structures carrier transport of system. polymers characterized their...
High-performance ternary π-conjugated copolymers containing diarylethylene units were designed and synthesized.
Two new cucurbitane triterpenoids 1 and 2 were isolated, together with six known compounds, from the seeds of Momordica charantia L. The structures compounds determined to be 3-O-{[β-d-galactopyranosyl(1 → 6)]-O-β-d-galactopyranosyl}-23(R), 24(R), 25-trihydroxycucur-bit-5-ene (1), 3-O-[β-d-galactopyranosyl]-25-O-β-d-galactopyranosyl-7(R), 22(S), 23(R), 25-pentahydroxycucurbit-5-ene (2), respectively. Their elucidated by combination mass spectrometry, one- two-dimensional NMR experiments...
Four novel cyclic peroxide glucosides 15a, 15b, 16a, and 16b, optically pure analogs of shuangkangsu (1), which is an anti-virus natural product with unusual skeleton isolated from the buds Lonicera japonica Thunb, were first synthesized totally in six steps including cycloaddition furan diethyl acetylenedicarboxylate glycosylation.
A series of novel substituted uracil-1'(N)-acetic acid esters (5–9) and 4-pyridone-1'(N)-acetic (10–11) 20(S)-camptothecins (CPTs) have been synthesized by the acylation method. All these new were assayed for in vitro cytotoxicity against five human cancer cell lines A549, Bel7402, BGC-823, HCT-8 A2780. The bioassay results showed that all compounds 5–11 had cytotoxities higher than TPT comparable to CPT on tumor lines, some them even or superior cytotoxic activity CPT. data exhibited ester...
In an attempt to improve the antitumor activity of homocamptothecins (hCPTs), a series novel 20-O-linked hCPT ester derivatives were first designed and synthesized based on synthetic route, by which hCPTs are acylated with different substituted phenoxyacetic acid derivatives. Most assayed for in vitro cytotoxicity against six human cancer cell lines KB, KB/VCR, A549, HCT-8, Bel7402, A2780, most compounds exhibited good antiproliferative these tumor especially KB.
Four novel optically pure cycloperoxide glucosides 9a, 9b, 10a, and 10b, analogs of shuangkangsu – a natural product with unusual skeleton antivirus activity from the buds Lonicera japonica Thunb, were firstly synthesized by employing peroxidation glucosidation reactions phthalaldehyde or 4,5-dichloro glucose.
Small-molecule compounds based on diketopyrrolopyrrole and cyano substituted dithiophene-ethylene were synthesized their properties systematically studied.
Based on diketopyrrolopyrrole (DPP) and (E)-3-phenyl-2-(thiophen-2-yl)acrylonitrile (BVCNT)-linked conjugated backbones, three donor–acceptor type organic small-molecule compounds DPP-BVCNT, DPP-2FBVCNT, DPP-3FBVCNT were designed synthesized. Among them, the 2-decyltetradecyl side chain DPP acceptor unit was used to ensure solubility of material. The fluorine (F) atoms combined with nitrile BVCNT donor adjust electronic structures charge carrier transport properties system. All small...