A5070870256- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Renal and related cancers
- Birth, Development, and Health
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Balance, Gait, and Falls Prevention
- Chronic Kidney Disease and Diabetes
- Effects of Vibration on Health
- Neonatal and fetal brain pathology
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer-related Molecular Pathways
- Barrier Structure and Function Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebral Palsy and Movement Disorders
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- TGF-β signaling in diseases
- Congenital Heart Disease Studies
Semmelweis University
2015-2025
Cancer progression towards metastasis follows a defined sequence of events described as the metastatic cascade. For extravasation and transendothelial migration cells interact first with endothelial cells. Yet role during process formation is still unclear, interaction between poorly understood. Since tumor are well known to express TGF-β, compact layer undergoes series changes (cell contact disruption, cytoskeletal reorganization, enhanced contractility), we hypothesized that an EndMT may...
Background Minimizing the duration of mechanical ventilation is one most important therapeutic goals during care preterm infants at neonatal intensive units (NICUs). The rate extubation failure among between 16% and 40% worldwide. Numerous studies have been conducted on assessment suitability, optimal choice respiratory support around extubation, effectiveness medical interventions. Since Caffeine Therapy for Apnea Prematurity (CAP) trial, caffeine has become essential drugs NICUs. However,...
Background: The importance and etiology of meconium-stained amniotic fluid (MSAF) in preterm pregnancies are still poorly understood. Among other factors, intrauterine inflammation is proposed to be a pathophysiological change associated with MSAF. To study the extent inflammation, histological evaluation represents “gold standard” diagnostics. Objectives: investigate concomitant occurrence MSAF chorioamnionitis (HCA) fetal inflammatory response (FIR). incidence short-term neonatal outcomes...
The limit of viability for premature newborns has changed in recent decades, but whether to initiate or withhold active care periviable infants remains a subject debate because the chances survival and extent severe neurological impairment can be unclear. In our review, we analyzed large population-based studies from past 2 decades. We compared rates incidence early complications among survivors, including bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia,...
BACKGROUND:In our previous study, some changes were presented in obstetric care and we studied the morbidity mortality trends of infants with <500 grams birth weight. Several neonatal protocol occurred during study period. The aim this was to analyze premature light changing protocols. MATERIAL AND METHODS:We performed a retrospective weight, born at department between 2006 2015. We divided period into two 5-year epochs compared rates. calculated duration mechanical ventilation non-invasive...
Abstract Background There are limited data available on the survival and early complications of preterm infants with less than 500 g birthweight. To estimate outcomes for these infants, it is important caregivers to be aware perinatal factors that may affect survival. Objectives We assessed mortality certain born in Hungary between 2006 2015. Methods reviewed 486 from database Hungarian Central Statistical Office parallel 407 “NICU database.” The study period was divided into two epochs:...
Abstract Endothelial-mesenchymal transition (EndMT) is an embryonic program necessary for organ development. Despite being normally dormant in adult organisms, this mechanism can be reactivated during several pathological conditions, such as cancer and fibrosis. EndMT characterized by the downregulation of endothelial program, activation mesenchymal-fibrogenic finally myogenic program. Cancer progression towards metastasis follows a defined sequence events described metastatic cascade. For...