A5087322657- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Medicinal Plant Pharmacodynamics Research
- Ferroptosis and cancer prognosis
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- TGF-β signaling in diseases
- Healthcare and Venom Research
- Synthesis of Organic Compounds
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Potato Plant Research
- Carbohydrate Chemistry and Synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Proteoglycans and glycosaminoglycans research
- Ginseng Biological Effects and Applications
- Glutathione Transferases and Polymorphisms
- Botanical Studies and Applications
- Biochemical and Molecular Research
- Bioactive Natural Diterpenoids Research
- Circular RNAs in diseases
Nanjing University of Chinese Medicine
2016-2024
Jiangsu Province Hospital
2012-2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2008-2012
Nanjing University
2012
Dehydrocostus lactone (Dehy), a natural sesquiterpene from Saussurea lappa Clarke, displays remarkable efficacy in treating cancer and gastrointestinal disorders. However, its anti-gastric (GC) effect remains poorly understood. Our study aimed to elucidate the anti-GC of Dehy putative mechanism. The was assessed with MTT, colony formation, wound healing transwell invasion assays. Cell apoptosis rate detected by Annexin V-FITC/PI binding assay. Network pharmacology analysis XF substrate...
// Jin-Yong Zhou 1, * , Min Chen 2, Long Ma 3, Xiaoxiao Wang 4 Yu-Gen 5, Shen-Lin Liu 6 1 Central Laboratory, The Affiliated Hospital of Nanjing University Chinese Medicine, Jiangsu Province Traditional Nanjing, China 2 Department Internal 3 Urology, Medical Science Research, 5 Colorectal Surgery, Oncology, These authors contributed equally to this work Correspondence to: Liu, e-mail: jsszyylsl@163.com Keywords: CD133, CD44, cancer stem cells (CSCs), colorectal cancer, biomarkers Received:...
Follistatin-related gene 3 (FSTL3), an established oncogene, can modulate target expression via members of the transforming growth factor β (TGF-β) superfamily. The present study was conducted to evaluate FSTL3 in gastric cancer (GC) and determine its prognostic significance. We also evaluated possible mechanisms involved oncogenic role carcinogenesis development.We obtained data from Human Protein Atlas, MethSurv, cBioPortal, UALCAN, TIMER, GEPIA, STRING, GeneMANIA, ONCOMINE, MEXPRESS...
Beta-asarone is one of the main bioactive constituents in traditional Chinese medicine Acorus calamu. Previous studies have shown that it has antifungal and anthelmintic activities. However, little known about its anticancer effects. This study aimed to determine inhibitory effects on LoVo colon cancer cell proliferation clarify underlying mechanisms vitro vivo. Dose-response time-course anti-proliferation were examined by MTT assay. Our results demonstrated viability showed dose-...
Introduction: Epithelial-mesenchymal transition (EMT) is regarded as a crucial process of invasion and metastasis, which contribute greatly to cancer-related relapse death. Based on research results that hypoxia can trigger gastric cancer EMT decreasing lactate production selectively kill hypoxic cells, we infer dehydrogenase A (LDH-A) transforming pyruvate into at least in part responsible for poor prognosis cancer. Materials methods: We used siRNA knock down LDH-A intestinal-type (ITGC)...
The present study evaluated whether magnetic nanoparticles containing Fe(3)O(4) could enhance the activity of gambogic acid in human colon cancer cells, and explored potential mechanisms involved.Cytotoxicity was by MTT assay. percentage cells undergoing apoptosis analyzed flow cytometry, cell morphology observed under both an optical microscope a fluorescence microscope. Reverse transcriptase polymerase chain reaction Western blot assay were performed to determine transcription genes...
Background. Yiqi Huayu Jiedu Decoction (YHJD) can obviously improve the quality of life those patients with gastric cancer and prolong their survival. Methods . In vitro experiments, we observe YHJD’s effect on cells’ proliferation by MTT assay. Cell adhesion assay, wound-healing Transwell invasion assay serve to detect its influence adhesion, migration, invasion, respectively. Inhibitor (10 μ M/L SB431542) activator ng/mL TGF- β ) /Smad pathway were used estimate whether impact biological...
To explore the role of CWP in invasion and migration gastric cancer cells its underlying molecular mechanism, we performed experiment SGC-7901 both vitro vivo . In cell experiment, evaluated proliferation by MTT assay. The results showed that can inhibit growth cells. influence on was detected wound-healing Transwell assays. abilities are restrained group. Western blot decrease expression Cox-2 PI3K/AKT/GSK3 β / -catenin signaling pathway. animal observed had an inhibitory effect xenograft...
Traditional Chinese medicine (TCM) is increasingly extensively being applied as a complementary and alternative therapy for gastric cancer (GC); however, there lack of large-scale evidence-based deep learning the guidance its clinical prescription.The combinational search terms "Gastric and/or malignancy" "Traditional Medicine" were used to retrieve study-based herbal prescriptions from public database over past 3 decades [1990-2020]. Association rules mining (ARM) was analyze prescription...
Purpose: To explore the role of thyroid hormone receptor interactor 13 (TRIP13) in gastric cancer (GC) and associated mechanism.
 Methods: TRIP13 expression GC was found The Cancer Genome Atlas (TCGA) database siTRIP13 transfected cells order to generate cell lines with low expression. Cell proliferation determined by colony formation assay, while migration invasion were evaluated scratch test Transwell respectively. Sphere assay used assess stemness characteristics whereas...
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, underscoring the need for novel therapeutic targets. This study aimed to elucidate role endoplasmic reticulum membrane protein complex subunit 1 (EMC1) in HCC progression and its potential.
Purpose: Gastric cancer (GC) is a common type of worldwide. It can relapse and metastasize even after standard treatment; therefore, it has poor prognosis. Moreover, sensitive biomarkers for prognosis prediction in GC are lacking. In this study, using bioinformatics approach, we aimed to examine the value DAZ Interacting Protein 1 ( DZIP1 ) as prognostic predictor therapeutic target GC. Methods: We explored clinical relevance, function, molecular role MethSurv, cBioPortal, TIMER, Gene...
Clinically, Jian Pi Yang Zheng Xiao (JPYZXZ) has been used for many years to treat gastric cancer (GC); however, the underlying mechanism and targets are still undetermined. The active JPYZXZ components were assessed by Liquid chromatography combined with quadrupole-orbitrap high-resolution mass spectrometry (LC-Q-orbitrap-HRMS). These findings TCM Systematic Pharmacology Database Analysis Platform (TCMSP) database perform network pharmacological analysis. Using second-generation sequencing...
The goal of the current research was to investigate circATXN7 expression in esophageal cancer (EC) and its impact on proliferation, migration, invasion EC cells.Determination tissues adjacent tissueswas carried out using quantitative reverse transcription polymerase chain reaction (qRT-PCR), we further analyzed correlation between patients' clinical characteristics expression. cell lines (EC-9706, Eca-109, TE-1, KYSE-30, KYSE-150) normal line (HET-1A) were cultured, detected by qRT-PCR....