A5084059283- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Particle physics theoretical and experimental studies
- RNA and protein synthesis mechanisms
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- RNA modifications and cancer
- Superconducting Materials and Applications
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Cholinesterase and Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Protein Structure and Dynamics
- thermodynamics and calorimetric analyses
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Particle Accelerators and Free-Electron Lasers
- Nuclear physics research studies
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Astrophysics and Cosmic Phenomena
- High-Energy Particle Collisions Research
- Scientific Computing and Data Management
Casa Sollievo della Sofferenza
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
European Institute of Oncology
2022-2023
University of Rome Tor Vergata
2000-2021
Bristol Robotics Laboratory
2008
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2000-2002
The process of aging is a complex phenomenon that involves progressive decline in physiological functions required for survival and fertility. To better understand the mechanisms underlying this process, scientific community has utilized several tools. Among them, mitochondrial DNA emerged as crucial factor biological aging, given dysfunction thought to significantly contribute phenomenon. Additionally, Drosophila melanogaster proven be valuable model organism studying due its low cost,...
RNA molecules are able to bind proteins, DNA and other small or long RNAs using information at primary, secondary tertiary structure level. Recent techniques that use cross-linking immunoprecipitation of can detect these interactions and, if followed by high-throughput sequencing, be analysed find recurrent elements shared interactors, such as sequence and/or motifs. Many tools motifs from lists target RNAs, while others focus on different approaches specific interaction elements. In this...
Abstract The interaction between RNA and RNA-binding proteins (RBPs) has a key role in the regulation of gene expression, stability, many other biological processes. RBPs accomplish these functions by binding target molecules through specific sequence structure motifs. identification motifs is therefore fundamental to improve our knowledge cellular processes how they are regulated. Here, we present BRIO (BEAM Interaction mOtifs), new web server designed for one or more interest. enables user...
Risk and outcome of acute promyelocytic leukemia (APL) are particularly worsened in obese-overweight individuals, but the underlying molecular mechanism is unknown. In established mouse APL models (Ctsg-PML::RARA), we confirmed that obesity induced by high-fat diet (HFD) enhances leukemogenesis increasing penetrance shortening latency, providing an ideal model to investigate obesity-induced events preleukemic phase. Surprisingly, despite DNA damage hematopoietic stem cells (HSC), HFD only...
Abstract Motivation RNA structural motif finding is a relevant problem that becomes computationally hard when working on high-throughput data (e.g. eCLIP, PAR-CLIP), often represented by thousands of molecules. Currently, the BEAM server only web tool capable to handle tens in input with discovery procedure limited current secondary structure prediction accuracies. Results The recently developed method (BEAr Motifs finder) can analyze molecules and identify motifs associated measure their...
Abstract Structural characterization of RNAs is a dynamic field, offering many modelling possibilities. RNA secondary structure models are usually characterized by an encoding that depicts structural information the molecule through string representations or graphs. In this work, we provide generalization BEAR (a context-aware previously developed) expanding set alignments used for construction substitution matrices and then applying it to encodings ranging from fine-grained more...
The worldwide computing grid is essential to the LHC experiments in analysing data collected by detectors. Within LHCb, model aims simulate at Tier-2 sites as well non-grid resources. reconstruction, stripping and analysis of produced LHCb will pimarily place Tier-1 centres. challenge DC06 started May 2006 with primary being exercise mod produce events which be used for analyses forthcoming physics book. This paper gives an overview addresses challenges experiences during DC06. management...
<p>Supplementary Figure S2: extension of RNAseq and PPARd ChIPseq analysis, related to figure 6</p>
<p>Supplementary Figure S2: extension of RNAseq and PPARd ChIPseq analysis, related to figure 6</p>
<div>Abstract<p>Risk and outcome of acute promyelocytic leukemia (APL) are particularly worsened in obese-overweight individuals, but the underlying molecular mechanism is unknown. In established mouse APL models (Ctsg-PML::RARA), we confirmed that obesity induced by high-fat diet (HFD) enhances leukemogenesis increasing penetrance shortening latency, providing an ideal model to investigate obesity-induced events preleukemic phase. Surprisingly, despite DNA damage hematopoietic...