Extent of resection is a major goal and prognostic factor in the treatment gliomas. In this study we evaluate whether quantitative ex vivo tissue measurements δ-aminolevulinic acid–induced protoporphyrin IX (PpIX) identify regions increasing malignancy low- high-grade gliomas beyond capabilities current fluorescence imaging patients undergoing fluorescence-guided (FGR). Surgical specimens were collected from 133 biopsies 23 processed for neuropathological analysis: PpIX fluorimetry to...

We attempt to demonstrate the regulatory role of miR-200c in glioma progression and its mechanisms behind.Here, we show that expression was significantly reduced tissues compared paratumor tissues, especially malignant glioma.Exogenous overexpression inhibited proliferation invasion cells.In addition, vivo mouse xenograft model showed growth liver metastasis, which is mainly regulated by targeting moesin (MSN).We demonstrated MSN specimens were negatively correlated with expression, rescued...

The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression, participates in cytokine secretion many diseases. However, the effects of experimental subarachnoid hemorrhage remain to be studied. A model was established rats by infusing autologous blood into optic chiasm pool. Some were first treated JAK2/STAT3 small interfering RNA (Si-JAK2/Si-STAT3) or overexpression plasmids JAK2/STAT3. In brains rats, expression levels both JAK2 STAT3 upregulated SOCS1 downregulated,...

<b><i>Background:</i></b> Internal neurolysis (IN) is an effective surgical treatment for trigeminal neuralgia (TN) without neurovascular compression (NVC) or postoperative recurrence. However, the nerve directly manipulated during procedure, and there a high incidence of trigeminocardiac reflex (TCR). The aim this study was to retrospectively analyze outcome IN explore its relationship with occurrence intraoperative TCR. <b><i>Methods:</i></b>...

Radiometers and Wearable biosensors, as vital parts of the realm quantum medicine, are becoming popular for their ability to continuously immediately provide physiological data through single-cell spectroscopy, brain imaging, noninvasive monitoring biochemical markers in various neuroimaging biofluids such sweat, tears, interstitial fluid. Various biosensing, microfluidic sampling, transport technologies have been combined, made smaller, incorporated with flexible materials improve ease use...

The majority of spinal cavernous angiomas (CAs) originate from the vertebral bodies with or without epidural space extension. Solitary CAs are rare. In present study, we retrospectively reviewed records 12 patients who underwent microsurgery for solitary CAs. All had performed pre- and postoperative magnetic resonance imaging. were 7 females 5 males mean age 52.1 years. Two tumors located in cervicothoracic spine, nine thoracic spine one lumbar respectively. generally exhibited isointensity...

Glioblastoma (GBM) is among the most common and aggressive adult central nervous system tumors. One prominent characteristic of GBM presence abnormal microvessels. A significant correlation between angiogenesis prognosis has been observed. Accurately reconstructing this neovascularization tumor microenvironment through personalized in vitro disease models presents a challenge. However, it crucial to develop new anti-angiogenic therapies for GBM. In study, 3D bioprinted glioma stem cell...

Objective To find the microstructural damage of white matter fiber network in patients with mild traumatic brain injury using diffusion tensor magnetic resonance imaging(DTI)and discuss clinical significance these changes. Methods Eighteen injury, received treatment our hospital from April 2015 and September 2015, were included as patient group, while 18 gender-, age-and education degree-matched healthy subjects used control group; they all accepted scanning during 3 or 4 weeks after...

We reviewed our institutional experience during a 10-year period for improvement of safety and efficacy stereotactic biopsy procedures.We performed retrospective review inpatient summaries, worksheets radiologic investigations 208 consecutive patients, who underwent MRI-guided biopsies between March 2010 2020.The overall diagnostic yield was 96.2%. CT-confirmed intracranial hemorrhage occurred in 17 patients (8.2%), the mortality rate 0.5%. Combined MRS PWI helped target selection 27 cases...

To investigate the effect of transtemperal approach and placement intracranial pressure sensor into temporal horn lateral ventricle in management spontaneous supratentorial intracerebral hemorrhage broken ventricles, a total 37 patients with ventricles treated by operation from January 2016 to December 20l6 were analyzed retrospectively, which 25 simple transtemporal group 12 group. All followed up for 8 months 1.5 years. Two groups estimated mortality, clearance rate hematoma, removal bone...

Objective Aneurysmal recanalization is related to aneurysmal occlusion degree, and dense may decrease the recurrence rate after treatment. The purpose of this study analyze influencing factors associated with immediate angiographic results intracranial aneurysms endovascular coiling, so as provide guidance for clinical treatment. Methods A retrospective analysis data 352 patients aneurysms, admitted our hospital from January 2011 December 2013 treated was performed. Clinical imaging...

Objective To investigate the operation strategy and advantages of multimodal imaging guided stereotactic biopsy simultaneous ventriculoperitoneal shunt for thalamic gliomas.Methods Thirty-seven patients with gliomas,admitted to our hospital from April 2008 September 2013,were chosen in study; 15 them were performed 22 only biopsy; their clinical data efficacy compared.Results All confirmed as having gliomas by intraoperative frozen section postoperative regular pathologic...

Objectives To summarize the preliminary experience of endovascular treatment irregular and complicated intracranial aneurysms with double microcatheter technique to investigate feasibility its application. Methods From January 2012 May 2015, clinical data 37 patients aneurysm admitted Department Neurosurgery, Anhui Provincial Hospital were analyzed retrospectively. All treated endovascularly by using technique, 33 them alone 4 stent-assisted technique. Prognosis evaluated Glasgow...

Objective To evaluate the clinic effects of electrophysiological monitoring during microvascular decompression(MVD) for hemifacial spasm(HFS) . Methods From June 2012 to May 2014, 76 HFS patients were performed with intraoperative abnormal muscle reaction(AMR) and facial-motor evoked potentials(facial-MEP) MVD. The therapeutic effect was evaluated at 1 week 3 months postoperation. relationship between AMR changes prognosis, Facial-MEP postoperative early facial paralysis in period...

Objective To conclude the application experience of intraoperative ultrasound added with neuronavigation in resection intracranial gliomas.Methods A retrospective analysis was performed on clinical data 60 patients gliomas,performed our hospital from January 2010 to June 2013 by neuronavigation; 32 them had high-grade gliomas and 28 low-grade ones.Ultrasonoscopy different grade studied.Results The accuracy localization 100％ gliomas.Ultrasonic image enjoyed obvious hyperechogenicity...

Objective To explore surgical techniques and curative effects of microsurgical treatment for neurilemmoma in upper cervical spinal canal. Methods From Jan. 2004 to Nov. 2007, 59 cases schwannoma was resected through microoperation, the operation conducted a posteromedial approach, using German Laika microscope resection tumor, large tumors cannot complete resection,block or sac, postoperative neck activity conventional restrictions, with following observation 6 months-2 years. Results A...

Objective To discuss the clinical value of intraoperative ultrasonography added with neuronavigation in intracranial lesions resection.Methods The materials 42 cases which were resected by between January 2010 to July 2011 retrospectively analysised.There 30 male and 12 female,aged from 13 70 years old,with a mean age 42.9 old.The brain shift neuronavigation,the ultrasonic image operation skills focused on.Results accuracy localization was 100％ caseswith neuronavigation.Intraoperative can...

Objective To investigate the relationship between grade of gliomas and status adjacent fiber tract with DTL Methods MRI DTI were performed in 24 patients histologically confirmed brain gliomas.Regions interest placed white matter to tumor lowest FA(Faa) contralateral hemisphere(Fac).The values Faa Fac measured.In regions same slice, ADCa ADCc measured. Relative fractional anisotropy ratios (rFA) relative apparent diffusion coefficient (rADC) also calculated.The tracts characterized as...