A5029899036- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Healthcare cost, quality, practices
- Parasites and Host Interactions
- Infective Endocarditis Diagnosis and Management
- Patient Satisfaction in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Global Maternal and Child Health
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Surgical site infection prevention
- Global Health Workforce Issues
- Immune Cell Function and Interaction
- Glaucoma and retinal disorders
- Vaccine Coverage and Hesitancy
- Healthcare Decision-Making and Restraints
- Advanced Image Processing Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Influenza Virus Research Studies
- Healthcare Policy and Management
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
Boston Medical Center
2018-2025
Boston University
2018-2024
University Medical Center
2018-2020
Biology of Infection
2018
Engineering Associates (United States)
2018
VA Boston Healthcare System
2018
McGill University
2011
Abstract Background Early pathogen ID and targeted treatment are key to reducing bloodstream infection (BSI) morbidity mortality. Current diagnostics rely on culture which takes 1-2 days for longer antimicrobial susceptibility testing (AST) results, or molecular assays with limited panels, few resistance markers, high false positive rates. We report interim results of a first-in-kind comprehensive predictive AST assay directly from patient blood samples. The system can deliver in ∼8 hrs,...
Background Integrase strand transfer inhibitors (INSTIs) have been associated with excess weight gain in people living HIV compared to other antiretroviral agents. The mechanisms that underlie these effects are not well defined. Thus, we aimed examine the of switching INSTI-containing regimens on clinical metabolic parameters. Setting A secondary analysis a prospective cohort study which stable efavirenz-based regimen were switched cobicistat-boosted elvitegravir or raltegravir-containing...
Abstract Objective: To measure the association between receipt of specific infection prevention interventions and procedure-related cardiac implantable electronic device (CIED) infections. Design: Retrospective cohort with manually reviewed status. Setting: National, multicenter Veterans Health Administration (VA) cohort. Participants: Sampling procedures entered into VA Clinical Assessment Reporting Tracking-Electrophysiology (CART-EP) database from fiscal years 2008 through 2015. Methods:...
Chronic inflammation is prevalent with antiretroviral therapy (ART)-suppressed human immunodeficiency virus (HIV) infection and one immune cell subset putatively driving this phenomenon TIGIT+ γδ T cells.
Abstract Despite effective antiretroviral therapy (ART), transcriptionally competent HIV-1 reservoirs persist and contribute to persistent immune activation in people living with HIV (PWH). HIV-1-infected macrophages are important mediators of chronic innate activation, though mechanisms remain unclear. We previously reported that nuclear export cytoplasmic expression intron-containing RNA (icRNA) activates mitochondrial antiviral signaling protein (MAVS)-mediated type I interferon (IFN)...
Abstract Background The rate of cardiovascular implantable electronic device (CIED) infection is increasing coincident with an increase in the number procedures. Preprocedural antimicrobial prophylaxis reduces CIED infections; however, there no evidence that prolonged postprocedural antimicrobials additionally reduce risk. Thus, we sought to quantify harms associated this approach. Objective To measure association between Clostridium difficile (CDI), acute kidney injury (AKI) and receipt...
The biological mechanisms by which efavirenz (EFV) causes central nervous system (CNS) effects are unclear. objective of this pilot study was to elucidate the underlying these CNS correlating well-described neuropsychological (NP) changes with neurometabolites and immunologic markers following switch off EFV.Two single-arm parallel studies among HIV-infected adults in Boston, USA, from 2015 2017.Twenty asymptomatic on EFV-containing regimens were switched an integrase strand transfer...
Excessive weight gain associated with integrase strand transfer inhibitor (InSTI) antiretrovirals is an emerging issue; however, the metabolic consequences of this effect have not been established. Our objective was to evaluate for InSTI-emergent and potential type 2 diabetes mellitus (T2DM) among a diverse HIV patient cohort. For retrospective cohort study, we obtained clinical warehouse data HIV+ patients between fiscal years 2007-17. We compared initiated on InSTI those started alternate...
Abstract Background Early in the coronavirus disease 2019 (COVID-19) pandemic, there was minimal data to guide treatment, and we lacked understanding of how clinicians translated this limited evidence base for potential therapeutics bedside care. Our objective systematically determine emerging about COVID-19 treatments implemented by analyzing institutional treatment protocols. Methods Treatment protocols from North American healthcare facilities recommendations guideline-issuing bodies were...
Abstract Background Antimicrobial prophylaxis is an evidence-proven strategy for reducing procedure-related infections; however, measuring this key quality metric typically requires manual review, due to the way antimicrobial documented in electronic medical record (EMR). Our objective was electronically measure compliance with using both structured and unstructured data from Veterans Health Administration (VA) EMR. We developed methodology cardiac device implantation procedures. Methods...
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Abstract Procedure-related cardiac electronic implantable device (CIED) infections have high morbidity and mortality, highlighting the urgent need for infection prevention efforts to include electrophysiology procedures. We developed validated a semi-automated algorithm based on structured health records data reliably identify CIED infections. A sample of procedures entered into Veterans’ Health Administration Clinical Assessment Reporting Tracking program from FY 2008–2015 was reviewed...
Opioid use may impact the HIV-1 reservoir and its reversal from latency. We studied forty-seven virally suppressed people with HIV (PWH) observed that lower concentration of latency agents (LRA), used in combination small molecules did not reverse latency, synergistically increased magnitude re-activation ex vivo, regardless opioid use. This LRA boosting, which combined a Smac mimetic or low-dose protein kinase C agonist histone deacetylase inhibitors, generated significantly more unspliced...
Abstract Background Excessive weight gain associated with integrase strand transfer inhibitor (InSTI) antiretrovirals is an emerging issue in the current antiretroviral treatment (ART) era. Despite known association between excess and impaired glucose tolerance general population, metabolic implications of InSTI-associated have not been established. The objective this study was to evaluate presence amongst a diverse, urban population investigate potential risk factors implications. Methods...
Ethical and logistical challenges of deploying experimental vaccines in humanitarian emergencies are exacerbated by a paucity safety efficacy data. For outbreaks caused pathogens with high mortality rates few treatments
Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are the imaging techniques for detection of Glioblastoma. However, a single modality is never adequate to validate presence tumor. Moreover, each represents different characteristic brain. Therefore, experts have analyze images independently. This requires more expertise by doctors delays diagnosis time. Multimodal Image Fusion process generating image high visual quality, fusing images. it introduces blocking effect, noise...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the ‘Save PDF’ action button.
Background: Antimicrobial prophylaxis is an evidence-proven strategy for reducing procedure-related infections; however, measuring this key quality metric typically requires manual review, due to the way antimicrobial documented in electronic medical record (EMR). Our objective was combine structured and unstructured data from Veterans’ Health Administration (VA) EMR create tool preincisional prophylaxis. We assessed methodology cardiac device implantation procedures. Methods: With clinician...
in Montreal, Canada Archana Asundi1, Momar Ndao2, Brian Ward2,3, Sonya Cnossen4, Michael Libman2,3 and Christina Greenaway2-5 1McGill University, Department of Internal Medicine, 2McGil University Health Centre, Division Infectious Diseases, 3McGill J.D. Maclean Centre for Tropical 4Jewish General Hospital, Lady Davis Institute Medical Research, 5Jewish Diseases
The opioid epidemic may impact the HIV-1 reservoir and its reversal from latency in virally suppressed people with HIV (PWH). We studied forty-seven PWH observed that lowering concentration of agents (LRA), used combination small molecules do not reverse latency, synergistically increases magnitude re-activation
Cardiovascular implantable electronic device (CIED) infections are highly morbid, thus peri-procedural prevention interventions employed to reduce them. However, little data exists evaluating the comparative effectiveness of these interventions. Thus, objective this study was measure association between infection and antimicrobial prophylaxis strategies procedure-related CIED among a national, multi-center cohort using nested case–control design. A selection procedures entered into VA...