A5076751413- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Allergic Rhinitis and Sensitization
- Spinal Cord Injury Research
- Contact Dermatitis and Allergies
- Advanced Neuroimaging Techniques and Applications
- Food Allergy and Anaphylaxis Research
- Neurosurgical Procedures and Complications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Syphilis Diagnosis and Treatment
- Dermatology and Skin Diseases
- Spinal Hematomas and Complications
- Muscle activation and electromyography studies
- Cerebrospinal fluid and hydrocephalus
- Medical Imaging and Analysis
- Sphingolipid Metabolism and Signaling
Universitätsklinik Balgrist
2020-2025
University of Zurich
2013-2025
University Hospital of Zurich
2015
University Medical Center Freiburg
2010-2012
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, spatiotemporal dynamics of grey white matter above below is understudied. Methods We acquired longitudinal data from 13 traumatic 3 patients (8–8 cervical thoracic injuries) within 1.5 years after 10 healthy controls over same period. The protocol encompassed structural diffusion-weighted MRI rostral (C2/C3) caudal (lumbar enlargement) to level track tissue-specific...
Fingolimod (FTY720, Gilenya, Novartis Pharma AG, Basel, Switzerland) is a sphingosin-1-phosphate (S1P) receptor modulator with immunomodulatory properties that traps naive and central memory T cells in lymph nodes, leading to reduced numbers of peripheral blood lymphocytes, the first licensed oral drug for multiple sclerosis (MS).1,2 We report case near fatal herpes simplex virus 1 (HSV-1) encephalitis under dose fingolimod patient MS.
This study aims to determine tissue-specific neurodegeneration across the spinal cord in patients with mild-moderate degenerative cervical myelopathy (DCM). Twenty-four DCM and 24 healthy subjects were recruited. In patients, a T2-weighted scan was acquired at compression site, whereas all participants T2*-weighted diffusion-weighted level (C2-C3) lumbar enlargement (i.e., rostral caudal site of compression). We quantified intramedullary signal changes, maximal canal compression, white (WM)...
<h3>BACKGROUND AND PURPOSE:</h3> The spinal cord is subject to a periodic, cardiac-related movement, which increased at the level of cervical stenosis. Increased oscillations may exert mechanical stress on tissue causing intramedullary damage. Motion analysis thus holds promise as biomarker related disease progression in degenerative myelopathy. Our aim was characterization motion patients with <h3>MATERIALS METHODS:</h3> Phase-contrast MR imaging data were analyzed 55 (37 men; mean age,...
Simultaneous assessment of neurodegeneration in both the cervical cord and brain across multiple centres can enhance effectiveness clinical trials. Thus, this study aims to simultaneously assess microstructural changes above stenosis degenerative myelopathy (DCM) using quantitative magnetic resonance imaging (MRI) a multicentre study.
Accurate and automatic MRI measurements are relevant for assessing spinal cord compression severity in degenerative cervical myelopathy (DCM) guiding treatment. The widely-used maximum (MSCC) index has limitations. Firstly, it normalizes the anteroposterior diameter by that above below but does not account size variation along superior-inferior axis, making MSCC sensitive to level. Secondly, shape varies across individuals, this variability. Thirdly, is typically calculated an expert-rater...
Neurogenic lower urinary tract dysfunction (NLUTD), including neurogenic detrusor overactivity (NDO) and sphincter dyssynergia, is one of the most frequent devastating sequelae spinal cord injury (SCI), as it can lead to incontinence secondary damage such renal failure. Transcutaneous tibial nerve stimulation (TTNS) a promising, non-invasive neuromodulatory intervention that may prevent emergence C-fibre evoked bladder reflexes are thought cause NDO. This paper presents protocol for TTNS in...
Background Sufficient and timely spinal cord decompression is a critical surgical objective for neurological recovery in injury (SCI). Residual compression may be associated with disturbed cerebrospinal fluid pressure (CSFP) dynamics. Objectives This study aims to assess whether intrathecal CSFP dynamics SCI following are feasible safe, explore the diagnostic utility. Methods Prospective cohort study. Bedside lumbar cervical MRI were obtained N = 9 mostly acute-subacute 2 patients...
Abstract Background and Purpose The timing of decision‐making for a surgical intervention in patients with mild degenerative cervical myelopathy (DCM) is challenging. Spinal cord motion phase contrast MRI (PC‐MRI) measurements can reveal the extent dynamic mechanical strain on spinal to potentially identify high‐risk patients. This study aims determine comparability axial sagittal PC‐MRI prospect improving clinical workup. Methods Sixty‐four DCM underwent scan assessing motion. agreement was...
Abstract The aim of this study was to determine tissue-specific blood perfusion impairment the cervical cord above compression site in patients with degenerative myelopathy (DCM) using intravoxel incoherent motion (IVIM) imaging. A quantitative MRI protocol, including structural and IVIM imaging, conducted healthy controls patients. In patients, T2-weighted scans were acquired quantify intramedullary signal changes, maximal canal compromise, compression. T2*-weighted applied all participants...
Abstract Objective Automatic and robust characterization of spinal cord shape from MRI images is relevant to assess the severity compression in degenerative cervical myelopathy (DCM) guide therapeutic strategy. Despite its popularity, maximum (MSCC) index has practical limitations objectively compression. Firstly, it computed by normalizing anteroposterior diameter that above below level compression, but does not account for fact itself varies size along superior-inferior axis, making this...
Abstract Peripheral neuropathy (PN) is the most common complication of diabetes. It characterized by sensory loss which often causes major health consequences including foot ulceration, chronic pain, poor mobility and increased risk falls. However, present treatments do not counteract cause disease, namely lack feedback, but rather aim at partial temporal symptoms relief (e.g. analgesics for pain or creams ulcers healing). Electrical stimulation a promising solution restoration, it yet...
Spinal canal narrowing with consecutive spinal cord compression is considered a key mechanism in degenerative cervical myelopathy (DCM). DCM common spine condition associated progressive neurological disability, and timely decompressive surgery recommended. However, the clinical radiological diagnostic workup often ambiguous, challenging confident proactive treatment recommendations. Cerebrospinal fluid pressure dynamics (CSFP) are altered by narrowing. Therefore, we aim to explore potential...
Introduction Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic incomplete spinal cord injury, but its pathophysiology poorly understood. As compression observed in standard MRI often fails to explain a patient's status, new diagnostic techniques assess DCM are one research priorities. Minor cardiac-related cranio-caudal oscillations by phase-contrast (PC-MRI) healthy controls (HCs), while they become pathologically increased patients suffering from degenerative...
Abstract Purpose Before the era of spinal imaging, presence a canal block was tested through gross changes in cerebrospinal fluid pressure (CSFP) provoked by manual compression jugular veins (referred to as Queckenstedt's test; QT). Beyond these changes, cardiac-driven CSFP peak-to-valley amplitudes (CSFPp) can be recorded during registration. This is first study assess whether QT repurposed derive descriptors CSF pulsatility curve, focusing on feasibility and repeatability. Method Lumbar...
Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain increased fall risk. However, present treatments do not counteract loss, but only partially manage its consequences. Electrical neural stimulation holds promise restore sensations, efficacy benefits in PN damaged nerves are yet unknown. We designed a wearable neuroprosthesis (NeuroStep) providing targeted neurostimulation undamaged nerve portion assessed...
Background . The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. objective this study evaluation ALFA bee venom (BV) and wasp (WV) in insect allergic patients. Methods Specific IgE BV WV was analyzed by ALFA, ALLERG-O-LIQ, ImmunoCAP 80 patients 60 control sera. Sensitivity specificity correlation results were calculated. Results sensitivity/specificity diagnosis 100%/83% 82%/97% WV. For patients, Spearman coefficient versus 0.79 0.80 However,...
Introduction Degenerative cervical myelopathy (DCM) is a disabling spinal disorder characterised by sensorimotor deficits of upper and lower limbs, neurogenic bladder dysfunction neuropathic pain. When suspected, MRI helps to reveal cord compression rules out alternative diagnoses. However, the correlation between radiological findings symptoms weak. Cerebrospinal fluid pressure (CSFP) analysis may complement appreciation be used for intraoperative postoperative monitorings in patients...
Degenerative cervical myelopathy (DCM) is hallmarked by spinal canal narrowing and related cord compression myelopathy. Cerebrospinal fluid (CSF) pressure dynamics are likely disturbed due to stenosis. The study aimed investigate the diagnostic value of continuous intraoperative CSF monitoring during surgical decompression. This prospective single center (NCT02170155) enrolled DCM patients who underwent decompression between December 2019 May 2021. Data from n = 17 were analyzed symptom...