A5072989541- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Maternal Mental Health During Pregnancy and Postpartum
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Child Nutrition and Water Access
- Child Abuse and Trauma
- Mobile Health and mHealth Applications
- Reproductive Health and Contraception
- Air Quality and Health Impacts
- Homelessness and Social Issues
- Poverty, Education, and Child Welfare
- Pregnancy and Medication Impact
- Intimate Partner and Family Violence
- Health Literacy and Information Accessibility
- Obesity, Physical Activity, Diet
- HIV Research and Treatment
- Pregnancy and preeclampsia studies
- Sex work and related issues
- Infant Development and Preterm Care
- Migration, Health and Trauma
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of Cape Town
2015-2024
Red Cross War Memorial Children's Hospital
2015-2024
Cancer Research And Biostatistics
2017-2020
Faculty of Public Health
2018
University of KwaZulu-Natal
2015-2017
Wellcome Centre for Infectious Diseases Research in Africa
2017
Columbia University
2016
South African Radio Astronomy Observatory
2016
Icahn School of Medicine at Mount Sinai
2016
October 6 University
2016
Abstract Background Maternal antenatal depression may be particularly prevalent in low‐ and middle‐income countries, but there is a paucity of data on its effect birth outcomes such settings. We investigated risk factors for the associations between infant D rakenstein C hild H ealth S tudy ( DCHS ), cohort study W estern ape, outh A frica. Methods The prevalence pregnant women enrolled from primary care clinics was measured using B eck epression I nventory BDI‐II ). Predictors were logistic...
Studies of antiretroviral therapy (ART) use during pregnancy in HIV-infected women have suggested that ART exposure may be associated with adverse birth outcomes. However, there are few data from sub-Saharan Africa where HIV is most common, and studies involving the World Health Organization's (WHO's) recommended first-line regimens. We enrolled consecutive pregnant a comparator cohort uninfected at primary-level antenatal care facility Cape Town, South Africa. Gestational assessment...
To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and HIV-unexposed children in the context universal maternal antiretroviral therapy (ART).Prospective study with antenatal enrolment follow-up breastfeeding HEU mother-infant pairs through 12-18 months postpartum.Peri-urban community, Cape Town, South Africa.HEU (n = 215) 306) children.Cognitive, motor language development at median 13 (interquartile range 12-14) age: continuous dichotomous Bayley Scales Infant Toddler...
Background As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels retention in HIV services and suboptimal adherence to ART postpartum period. We examined impact integrating for HIV+ mothers alongside infant follow-up within maternal child health (MCH) Cape Town, South Africa. Methods findings conducted a randomised trial among aged ≥18 years who initiated local antenatal care clinic...
Adequate antenatal care is important to both the health of a pregnant woman and her unborn baby. Given South Africa’s high rate cellphone penetration, mobile interventions have been touted as potentially powerful means disseminate information. This study aimed increase knowledge awareness by disseminating text messages about clinic procedures at visits, how be healthy during pregnancy. Participants recruited were women attending primary facility in Cape Town. A controlled clinical trial was...
Objectives Intimate partner violence (IPV) during pregnancy may be common in settings where HIV is prevalent but there are few data on IPV populations of HIV-infected pregnant women Southern Africa. We examined the prevalence and correlates among women. Setting A primary care antenatal clinic Cape Town, South Participants 623 consecutive initiating lifelong antiretroviral therapy. Measures IPV, depression, substance use psychological distress were assessed using 13-item WHO Violence Against...
Prevention of mother-to-child transmission HIV implementation faces significant challenges globally, particularly in the context universal lifelong antiretroviral therapy (ART) for all HIV-infected pregnant women.We describe rationale and methods Maternal Child Health-Antiretroviral Therapy (MCH-ART) study, an science project examining strategies providing care treatment to women who initiate ART during pregnancy their HIV-exposed infants.MCH-ART is composed 3 interrelated study designs...
Abstract Childhood malnutrition is highly prevalent in low‐ and middle‐income countries. The choices of complementary foods, which are important infant nutrition, poorly described this setting. We investigated feeding practices a South African birth cohort, the Drakenstein Child Health Study. Longitudinal data were collected from March 2012 to 2015. Feeding at birth, 6–10 14 weeks 6, 9, 12 months, using food frequency questionnaires. Anthropometry was measured months. quality diet analyzed...
Abstract Background : The numbers of women initiating lifelong antiretroviral therapy (ART) during pregnancy and postpartum is increasing rapidly, presenting a burden on health systems an urgent need for scalable models care this population. In pilot project, we referred who initiated ART to community‐based model differentiated services. Methods Eligible (on at least 3 months with viral load (VL)<1000 copies/mL) were offered choice two care: (i) referral existing system ‘adherence clubs’,...
BackgroundPrenatal and peripartum trauma may be associated with poor maternal–fetal outcomes. However, relatively few data on these associations exist from low-middle income countries, populations in transition.ObjectiveWe investigated the prevalence risk factors for maternal posttraumatic stress disorder (PTSD), their association adverse birth outcomes Drakenstein Child Health Study, a South African cohort study.MethodsPregnant women were recruited two clinics peri-urban community outside...
Prevention of unplanned pregnancy is a crucial aspect preventing mother-to-child HIV transmission. There are few data investigating how status and use antiretroviral therapy (ART) may influence planning in high burden settings. Our objective was to examine the prevalence determinants among HIV-positive HIV-negative women Cape Town, South Africa.
The use of mobile phones to deliver health care (mHealth) is increasing in popularity due the high prevalence phone penetration. This seen developing countries, where mHealth may be particularly useful overcoming traditional access barriers. Non-communicable diseases amenable interventions, and hypertension one with an escalating burden world.The objective this study was test whether dissemination information via a short message service (SMS) led improvements knowledge self-reported...
Points• Involving male partners in programmes to prevent mother-to-child transmission of HIV may improve programme coverage and infant outcomes.• Rates partner involvement remain low worldwide, detailed guidelines increase are lacking South Africa.• We recommend that African national provincial policies for preventing be adjusted explicitly include a focus on increasing they concrete descriptions how achieve this.• propose recommendations improving at policy, facility, community level.•...
Exposure to tobacco smoke in African infants has not been well studied, despite the high burden of childhood respiratory disease these communities.To investigate prevalence antenatal and early life exposure associations with infant birth outcomes an cohort, Drakenstein Child Health Study.Self-report questionnaires assessing maternal household smoking were administered. Maternal urine cotinine testing was conducted antenatally, at 6-10 weeks measure exposure. Multivariate regression models...
Abstract Aim This birth cohort study investigated longitudinal infant growth and associated factors in a multiethnic population living low‐resource district surrounding the town of Paarl South Africa. Methods Between March 2012 October 2014, all mothers attending their second trimester antenatal visit at Hospital were approached for enrolment. Mother–infant pairs followed from until 12 months age. Comprehensive socio‐demographic, nutritional psychosocial data collected birth, two, six...
The impact of HIV and antiretrovirals (ART) on long-term mental health in perinatally infected children has not been well studied sub-Saharan Africa where is most prevalent.Cape Town, South Africa.We investigated measures, including depression, anxiety, attention-deficit hyperactivity disorder, motivation, disruptive behavior, functioning adolescents (PHIV+) stable ART within the Cape Town Adolescent Antiretroviral Cohort. Two hundred four living with (median age 10 years; mean CD4 953) a...
Abstract Introduction Many prevention of mother‐to‐child HIV transmission programmes across Africa initiate ‐infected ( positive) pregnant women on lifelong antiretroviral therapy ART ) the first day antenatal care (“same‐day” initiation). However, there are concerns that same‐day initiation may limit patient preparation before starting and contribute to subsequent non‐adherence, disengagement from raised viral load. We examined if was associated with suppression engagement in during...
Tenofovir-diphosphate (TFV-DP) in dried blood spots (DBS) is an objective long-term adherence measure, but data are limited on its ability to predict virologic suppression (VS) people antiretroviral (ARV) treatment. There also no comparing DBS TFV-DP with plasma ARV concentrations as predictors of VS.Women who were a first-line regimen tenofovir, emtricitabine, and efavirenz (EFV) enrolled cross-sectional study. Plasma EFV tenofovir (TFV), assays, 30-day self-reported evaluated VS (<50...
Unintended pregnancies are common among women living with HIV, but there no data on their long-term impact treatment outcomes. In a cohort of initiating antiretroviral therapy (ART) during pregnancy, we examined the association between intendedness current measured antenatally, and elevated viral load up to 5 years postpartum.Prospective study enrolment at entry into antenatal care follow-up visits separate from routine care.At completed London Measure Unplanned Pregnancy. Mixed effects...