A5028835248- Seismic Performance and Analysis
- Glioma Diagnosis and Treatment
- Cinema and Media Studies
- Literature, Film, and Journalism Analysis
- Shakespeare, Adaptation, and Literary Criticism
- Diet and metabolism studies
- Risk and Safety Analysis
- Probabilistic and Robust Engineering Design
- Ear and Head Tumors
- Peripheral Neuropathies and Disorders
- Graphite, nuclear technology, radiation studies
- Parkinson's Disease and Spinal Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Cancer Treatment and Pharmacology
- Nuclear and radioactivity studies
- Structural Response to Dynamic Loads
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Structural Health Monitoring Techniques
- Byzantine Studies and History
- Intracerebral and Subarachnoid Hemorrhage Research
- Military Strategy and Technology
- Radio, Podcasts, and Digital Media
Center for Neuro-Oncology
2023-2025
Dana-Farber Cancer Institute
2023-2025
Massachusetts General Hospital
2023-2024
Brigham and Women's Hospital
2023
Dana-Farber Brigham Cancer Center
2023
Cedars-Sinai Medical Center
2019-2022
Neurology, Inc
2020-2021
Georgia Gwinnett College
2017
University of Florida
2001
Lawrence Livermore National Laboratory
1992
In CheckMate 204, nivolumab + ipilimumab showed high intracranial (IC) objective response rates (icORRs) in patients with melanoma brain metastases (MBMs). Using icORR as a surrogate for overall survival (OS) has prompted use of alternate criteria. To set the stage harmonized MBM trials, aim this exploratory analysis was to determine using several criteria and examine correlations survival.
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is an immune-mediated disorder of the central nervous system characterized by inflammatory response to amyloid-beta (Aβ) deposition within cerebral blood vessel walls. Immunosuppressive therapy mainstay treatment. We present a case CAA-ri in subject already on immunosuppressive after orthotopic heart transplantation (OHT). A 57-year-old man eight months post-OHT for sarcoid cardiomyopathy developed headaches and staring spells while...
Endolymphatic sac tumors (ELSTs) are rare, locally invasive, vascular of the temporal bone. These lesions associated with von Hippel-Lindau syndrome but may arise sporadically. Early surgical intervention is recommended to prevent permanent neurologic deficits; however, many ELSTs unresectable or subtotally resected due neurovascular compromise. Chemotherapeutic salvage therapy in trials neoplasms syndromes has targeted angiogenesis variable response. We present case a sporadic ELST,...
2076 Background: Facing limited treatment options, brain tumor patients are often highly motivated to use complementary therapies, including diet, help themselves. There is now an abundance of preclinical evidence suggesting possible benefit with a ketogenic diet (KD) for patients, but clinical still limited. Thus, we conducted single-arm, phase 1 safety and feasibility trial KD among recently diagnosed glioblastoma (GBM) during standard- of-care (SOC) treatment. Methods: Adults GBM within 3...
Abstract Objectives Retrospective evaluation of repairing distal radial and ulnar fractures in small breed dogs with the Synthes 1.5-mm locking Adaption plate system compare results a similar group patients repaired 2.0-mm limited contact-dynamic compression (LC-DCP). Methods Electronic medical records from one specialty referral centre were reviewed March 21, 2010, to October 9, 2015, for weighing less than or equal 4 kg that had one-third fracture adaption LC-DCP. Further inclusion...
Leung, Bo MD; Nelson, Thomas Willenberg, Rafer MD, PhD; Burford, Matthew MD Author Information
e14036 Background: Sleep disturbance is a common symptom experienced in patients diagnosed with glioblastoma (GBM) and has been correlated poor physical psychological outcomes. Advancements wearable technologies have allowed for the opportunity to obtain objective measures of sleep quality outside laboratory setting. Thus, we conducted secondary analysis remotely monitored data from phase 1 study newly GBM following classic ketogenic diet (KD) addition standard-of-care treatment. Methods:...
Abstract INTRODUCTION There is abundant interest in the potential therapeutic and supportive role of a ketogenic diet (KD) for glioblastoma patients. We conducted single-arm phase 1 trial to assess safety feasibility KD plus standard-of-care (SOC) patients (NCT03451799). METHODS Adults within 3 months diagnosis participated 16-week intervention classic 3:1 (grams fat : grams carbohydrate + protein) with dietitian support. Blood glucose ketone levels were assessed twice daily (Keto-Mojo),...
Abstract BACKGROUND Glioblastoma (GBM) is the most common malignant primary nervous system tumor and remains incurable with a poor prognosis despite current therapy. The standard for monitoring response to treatment, as defined by Response Assessment in Neuro-Oncology (RANO) criteria, relies on bidimensional (2D) measurement product of T1-gadolinium enhancing disease. However, due variability characterization, there considerable interest volumetric segmentation assess burden, which could be...
The Passenger: Antonioni's Cinema of Escape THOMAS ALLEN NELSON During the final stages in shooting a film provisionally titled Profession: Reporter, Michelangelo Antonioni an interview witii Philip Strick ("The Report," Sight and Sound [Winter 1973/74]) talked about his enthusiastic involvement development its script (from story by Mark Peploe "Fatal Exit") how it would inevitably be most "rationalized" film. He described film's as complex mosaic which began to crystalize : "one day...
When Thackeray in the 1840's wrote The Memoirs of Barry Lyndon, Esq., he did so during a period experimenting with aesthetics parody. While poking fun at sentimentalities first person confessional novel, form already worn out by Defoe and ridiculed Fielding, toyed fictive forms point view an age no longer impressed 18th century addiction to decorum language behavior; good sense was being replaced fascination various dynamics thought as means for exploring complex modes perception. In Lyndon...
Barry Lyndon: Kubrick's Cinema of Disparity by Thomas Allen Nelson* When Thackeray in the 1840's wrote The Memoirs Lyndon, Esq., he did so during a period experimenting with aesthetics parody. While poking fun at sentimentalities first person confessional novel, form already worn out Defoe and ridiculed Fielding, toyed fictive forms point view an age no longer impressed 18th century addiction to decorum language behavior; good sense was being replaced fascination various dynamics thought as...
Wednesday, April 29April 14, 2020Free AccessDaratumumab as First Line Therapy in a POEMS Syndrome Patient Demonstrating Atypical Features (451)Bo Leung, Thomas Nelson, and Matthew BurfordAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.451 Letters to the Editor
Thursday, April 30April 14, 2020Free AccessAmyloid Beta-related Angiitis in the Immunosuppressed: A Case Report (292)Thomas Nelson, Bo Leung, Serguei Bannykh, Jignesh Patel, Kevin Shah, and Oana DumitrascuAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.292 Letters to Editor