A5111899963- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Facial Rejuvenation and Surgery Techniques
- Dermatologic Treatments and Research
- Vascular Malformations and Hemangiomas
- Wound Healing and Treatments
- Laser Applications in Dentistry and Medicine
- Diagnosis and Treatment of Venous Diseases
- Anatomy and Medical Technology
- Vascular Malformations Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Digital Imaging in Medicine
- Cancer, Hypoxia, and Metabolism
- Dermatological and Skeletal Disorders
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Sarcoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Fibroblast Growth Factor Research
- Vascular Anomalies and Treatments
- Orthodontics and Dentofacial Orthopedics
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Intracranial Aneurysms: Treatment and Complications
Peking University Third Hospital
2014-2025
Peking University
2014-2025
Hebei Medical University
2021
Second Hospital of Hebei Medical University
2021
Gansu Provincial Hospital
2020
Periostin, a secreted extracellular matrix protein, is involved in the wound healing and pathological process of various human cancers. Keloid scars are fibroproliferative tumor-like lesions develop under local hypoxia. Using suppression subtractive hybridization, previous study, we found that periostin overexpressed keloids compared with hypertrophic scars. However, little known about regulation function keloids. In this examined effects on bioactivity keloid fibroblasts (KFs) order to...
Periostin, a secreted extracellular matrix protein, is highly expressed in wound healing and various types of human cancer involved angiogenesis. Keloids, considered dermal benign tumors, are granulomatous lesions characterized by capillary proliferation. However, the underlying regulatory mechanism angiogenesis keloids remains to be elucidated. The present study aimed examine effect periostin on keloids. expression was upregulated vessel density higher compared with normal tissue, observed...
Our previous study demonstrated altered glucose metabolism and enhanced phosphorylation of the PI3K/AKT pathway in keloid fibroblasts (KFb) under hypoxic conditions. However, whether influences KFb cell function by regulating conditions remains unclear. Here, we show that when was inactivated with LY294002, protein expression glycolytic enzymes decreased, while amount mitochondria mitochondrial membrane potential increased. The key parameters extracellular acidification rate markedly...
Background: miRNA, as a biological marker, had more and attention in recent years due to the important role it plays cancer. Currently, there are extensive studies on miRNAs, among which miR-330-3p is reported be implicated pathophysiological processes of various cancers. However, little progress has been made mechanism gastric Objective: To explore expression relevant PRRX1 cancer (GC). Methods: Forty-five GC patients (study group), from whom paired paracancerous tissues were collected,...
To investigate the effect of 810 nm near-infrared (NIR) laser on revascularization ischemic flaps.It has long been proved that photobiomodulation therapy (PBMT) improves blood supply flaps. NIR treatment hypodermis-located lesions and flap survival, but basic research use for is still lacking.We prepared two symmetrical random-pattern flaps backs 60 rats. Each was 6 cm long, 1 wide, to middle line. The were divided into an irradiated group internal control group. underwent postoperative with...
Abstract Background Implant-based breast reconstruction is easy to be performed but has flaws that an unnatural appearance might presented when no sufficient coverage existing. While autologous tissue also disadvantages like donor site scar and skin patch effect. There a demand for new method obtain natural aesthetic while surmounting drawbacks of conventional surgery. Methods A retrospective review thirty-one patients undergoing expander (TE)/implant two-stage with latissimus dorsi muscle...
Polyacrylamide hydrogel (PAHG), which had been used widely for breast augmentation, has banned more than 15 years. Patients who injected PAHG augmentation need evacuation surgery to remove as much possible. To provide a series of diagnosis and treatment process MRI intraoperative color Doppler ultrasound are combined maximal removal PAHG.
Purpose: This study aims to investigate whether contrast-enhanced ultrasound (CEUS) could be used reveal the status of blood supply superficial flap rat model in early postoperative stage. Methods: One viable and one ischemic random-pattern were prepared on left right back same respectively with a number 40. CEUS examinations applied within 12 h 7 days postoperatively, quantitative measurements microvascular volume (BV) base end both flaps expressed using acoustic intensity as ratio that...
Objectives: Interleukin (IL)-1 receptor-associated kinase 1 (IRAK1) is a very important immunomodulatory gene for autoimmune diseases located on the X chromosome. However, there was little study about correlation of IRAK1 functional single nucleotide polymorphisms with mRNA expression in neuromyelitis optica spectrum disorder (NMOSD) patients. In this study, we aimed to investigate plausible association polymorphism, expression, and NMOSD risk northern Chinese Han population. Methods: Four...
Abstract Background Keloids are disfiguring fibro-proliferative disorders characterized by glucose metabolism reprogramming, namely elevated glycolysis and compromised oxidative phosphorylation. Our previous study demonstrated altered enhanced phosphorylation of the PI3K/AKT pathway in keloid fibroblasts (KFb) under hypoxic conditions. However, whether influences KFb cell function regulating conditions remains unclear. Results findings revealed that when was inactivated with LY294002...
Blue rubber bleb nevus syndrome is a very rare systemic vascular malformation frequently affecting the skin and gastrointestinal tract. The pathogenesis of disease still unclear, standard treatment does not exist. This study reports two blue cases, which second patient received TEK gene mutations detection got low-dose sirolimus therapy, compared with first who was treated sirolimus. report shows some positive findings efficacy treatment. We postulate that play an important role in...
Objective To study the pathological mechanism of aseptic necrosis breast tissue after long-term augmentation injected with polyacrylamide hydrogel (PAHG). Methods We included patients who had no obvious clinical symptoms and underwent surgical removal PAHG in our hospital, excluding a history prosthesis implantation. Extracts were collected, then careful gross observation serial sections followed by HE, Mallory, toluidine blue staining, to observe histological structure collagen...