A5031738512- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Gynecological conditions and treatments
- Minimally Invasive Surgical Techniques
- PARP inhibition in cancer therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Hernia repair and management
- Clinical practice guidelines implementation
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Reproductive Biology and Fertility
- Intestinal and Peritoneal Adhesions
- Genetic factors in colorectal cancer
- Cancer survivorship and care
- Testicular diseases and treatments
Memorial Sloan Kettering Cancer Center
2015-2024
Cornell University
2015-2024
Henry Ford Hospital
2023
Kettering University
2022
University College Dublin
2019
AstraZeneca (Brazil)
2019
University of Southampton
2018
Icahn School of Medicine at Mount Sinai
2004-2017
Gynecologic Oncology Group
2016
Weatherford College
2007-2011
Abstract Purpose: The presence of similar histologic subtypes epithelial ovarian and endometrial cancers has long been noted, although the relevance this finding to pathogenesis clinical management is unclear. Despite characteristics, ovary endometrium are treated according organ origin. This study compares gene expression profiles analogous using same genomic platform determine similarities differences between these tumors. Experimental Design: Gene 75 (endometrioid, serous, clear cell)...
Abstract High-grade serous ovarian cancer (HGSOC) is an archetypal of genomic instability 1–4 patterned by distinct mutational processes 5,6 , tumour heterogeneity 7–9 and intraperitoneal spread 7,8,10 . Immunotherapies have had limited efficacy in HGSOC 11–13 highlighting unmet need to assess how the anatomical sites foci determine immunological states microenvironment. Here we carried out integrative analysis whole-genome sequencing, single-cell RNA digital histopathology multiplexed...
Abstract Papillary serous low malignant potential (LMP) tumors are characterized by features and metastatic yet display a benign clinical course. The role of LMP in the development invasive epithelial cancer ovary is not clearly defined. aim this study to determine relationships among ovarian cancers identify genes contributing their phenotypes. Affymetrix U133 Plus 2.0 microarrays (Santa Clara, CA) were used interrogate 80 microdissected malignancies along with 10 surface epithelium (OSE)...
<h3>Objective</h3> Risk-reducing salpingo-oophorectomy (RRSO) is recommended for women with <i>BRCA</i> mutation due to increased risk of pelvic serous carcinoma. Serous tubal intraepithelial carcinoma (STIC) a pathologic finding unknown clinical significance. This study evaluates the outcome patients isolated STIC. <h3>Materials/Methods</h3> We retrospectively reviewed medical records consecutive germline <i>BRCA1/2</i> or high-risk personal family history ovarian cancer who underwent RRSO...
The purpose of this phase II study was to evaluate hyperthermic intraperitoneal chemotherapy (HIPEC) with carboplatin for recurrent ovarian cancer during secondary cytoreductive surgery.Patients were intraoperatively randomly assigned HIPEC (800 mg/m2 90 minutes) or no HIPEC, followed by five six cycles postoperative IV carboplatin-based chemotherapy, respectively. Based on a binomial single-stage pick-the-winner design, an arm considered winner if ≥ 17 49 patients without disease...
To evaluate the risk of epithelial ovarian cancer (EOC) recurrence in patients with rising serum antigen 125 (CA-125) levels that remain below upper limit normal (< 35 U/mL).All treated for EOC between September 1997 and March 2003 were identified screened retrospectively following: (1) elevated CA-125 at time diagnosis, (2) complete clinical radiographic response (CR) to initial treatment normalization CA-125, (3) least three serial determinations remained within range, (4) and/or...
Abstract BACKGROUND. The objective of this study was to evaluate the role secondary cytoreductive surgery in outcome patients who had recurrent epithelial ovarian carcinoma that limited ≤5 recurrence sites within abdomen or pelvis on preoperative imaging studies and attempt define selection criteria associated with improved survival, specific attention number lesions suspicious for disease. METHODS. Patients underwent surgical cytoreduction cancer between September 1997 March 2005 were...
The TP53 mutation frequency in ovarian serous carcinomas has been reported to range between 50% and 80%, but a stringent analysis of using purified epithelial samples not yet performed accurately assess the correlate it with histologic grade. purpose this study was mutational profile relatively large series high-grade (53 primary 18 recurrent) 13 low-grade tumors DNA isolated from affinity-purified tumor cells vitro drug resistance. All were affinity purified, analyzed for mutations exons...