A5101583085- Dermatology and Skin Diseases
- Obsessive-Compulsive Spectrum Disorders
- Urticaria and Related Conditions
- Medicine and Dermatology Studies History
- Asthma and respiratory diseases
- Peripheral Neuropathies and Disorders
- Allergic Rhinitis and Sensitization
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Tryptophan and brain disorders
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Neurological Disorders and Treatments
- Contact Dermatitis and Allergies
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Immunodeficiency and Autoimmune Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cutaneous lymphoproliferative disorders research
- Eating Disorders and Behaviors
- Pediatric health and respiratory diseases
- Effects and risks of endocrine disrupting chemicals
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- HER2/EGFR in Cancer Research
- Horticultural and Viticultural Research
Massachusetts General Hospital
2014-2024
Harvard University
2016-2024
Monash University
2023
Canon (United States)
2022
Johns Hopkins University
2019-2021
Johns Hopkins Medicine
2019-2021
Connecticut College
2020
PhytoCeutica (United States)
2020
University Hospitals Bristol NHS Foundation Trust
2018
Bristol Royal Infirmary
2017
On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians researchers from complementary fields pediatrics: General developmental pediatrics, infectious diseases, immunology, rheumatology, neurology, child psychiatry. Participants were academicians with clinical research interests in pediatric autoimmune neuropsychiatric disorder associated streptococcus (PANDAS) youth, larger category...
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinically heterogeneous disorder with number of different etiologies and disease mechanisms. Inflammatory postinfectious autoimmune presentations PANS occur frequently, some clinical series documenting immune abnormalities in 75%-80% patients. Thus, comprehensive treatment protocols must include immunological interventions, but their use should be reserved only for cases which the symptoms represent underlying neuroinflammation or...
Objective: The objectives of this study were to identify unique clinical characteristics children with pediatric autoimmune neuropsychiatric disorders associated streptococcal infections (PANDAS) compared a control group non-PANDAS obsessive-compulsive disorder (OCD) respect ancillary symptoms, types obsessions and compulsions, symptom severity, co-morbid DSM-IV diagnoses. Method: Classification PANDAS was based on review psychiatric records using the criteria developed by Swedo colleagues....
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN remains to be fully elucidated, but emerging evidence suggests that neuroimmune alterations play principal roles in pathogenesis PN. There are several associated etiologic factors thought with PN, including dermatoses, systemic, infectious, psychiatric, and neurologic conditions. We conducted systematic literature...
Movement, behavioral, and neuropsychiatric disorders in children have been linked to infections a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. The purpose this study was determine if biomarkers, when used as group, confirmed acute disease Sydenham chorea (SC) Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal (PANDAS). IgG autoantibodies against four neuronal autoantigens (tubulin, lysoganglioside...
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus, but information on patient experience and impact quality of life (QoL) remains understudied.To characterize characteristics QoL in global sample patients with PN.An anonymous survey was distributed via support groups for PN.In total, 231 members responded to the survey. The majority respondents reported itch localized both nodules intervening (67.0%). Associated symptoms included prickling, pain,...
Abstract Atopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures AD AAs moderate to severe pruritus, lesional non-lesional punch biopsies were taken from AA patients along age-, race-, sex-matched controls. Histology skin showed psoriasiform spongiotic dermatitis, suggesting both Th2 Th17 activity. Gene Set Variation Analysis upregulation pathways versus control (p < 0.01), while Th1...
<h3>Importance</h3> The hypothesis that disrupted immune function is implicated in the pathophysiology of psychiatric disorders and suicide gaining traction, but underlying mechanisms are largely unknown. Primary humoral immunodeficiencies (PIDs) rare deficiencies system—mainly dysfunction antibody production—and associated with adverse health problems, such as recurrent infections autoimmune diseases. <h3>Objective</h3> To establish whether PIDs affect level lifetime suicidal behavior this...
Excoriation disorder is a psychocutaneous characterized by repetitive skin-picking and associated with significant morbidity. Currently, epidemiological data in patients excoriation are lacking so we sought to characterize common patient demographics comorbidities. We conducted retrospective case-control study comparing 250 age-, race- sex-matched controls identified between 2007 2019 at single tertiary care center. found that the majority of were female (76%), Caucasian (82%) unmarried...
Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a neurologist.Thirteen 15 (87%) had abnormalities detected PSG. Twelve evidence rapid eye movement (REM) motor disinhibition, as characterized excessive movement, laughing, hand stereotypies, moaning, or the...