A5033291833- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Eating Disorders and Behaviors
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Neural and Behavioral Psychology Studies
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Pain Management and Placebo Effect
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Peripheral Neuropathies and Disorders
- Neural dynamics and brain function
- Migraine and Headache Studies
- Autoimmune Neurological Disorders and Treatments
- Child Nutrition and Feeding Issues
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Restraint-Related Deaths
- Urological Disorders and Treatments
National Institutes of Health
2002-2024
National Institute of Neurological Disorders and Stroke
2020-2024
National Institute of Mental Health
2006-2021
Yale University
2010-2020
National Institute of Mental Health
2018
Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work this area focuses on schizophrenia. Here, we extend pediatric bipolar disorder (BD), thus demonstrating traction the developmental psychobiology perspective. To study amygdala dysfunction, examined mechanisms mediating face processing 22 youths (mean age 14.21 +/- 3.11 yr) with BD and 21 controls of comparable age,...
Background We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency allocate is well established anxiety other disorders of negative affect. SMD characterized by the affect irritability, longitudinal studies suggest childhood irritability predicts adult depression. Therefore, it important study pathophysiologic connections between disorders. Methods patients...
Background: The first cases of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were described>15 years ago. Since that time, the literature has been divided between studies successfully demonstrate an etiologic relationship Group A (GAS) and childhood-onset obsessive-compulsive disorder (OCD), those fail to find association. One possible explanation for conflicting reports is diagnostic criteria proposed PANDAS are not specific enough...
The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array biological, social, and environmental factors can have lasting impacts on structure function. To understand how prenatal early life experiences alter neurodevelopmental trajectories shape health outcomes, several NIH Institutes, Centers, Offices collaborated to support launch HEALthy Brain Child Development (HBCD) Study. HBCD Study is multi-site prospective longitudinal cohort study,...
Movement, behavioral, and neuropsychiatric disorders in children have been linked to infections a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. The purpose this study was determine if biomarkers, when used as group, confirmed acute disease Sydenham chorea (SC) Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal (PANDAS). IgG autoantibodies against four neuronal autoantigens (tubulin, lysoganglioside...
While much is known about the neural regions recruited in human brain when a dominant motor response becomes inappropriate and must be stopped, less that support switching to new, appropriate, response. Using functional magnetic resonance imaging with two variants of stop-signal paradigm require either stopping altogether or different response, we examined systems involved these forms executive control. Both trials showed common recruitment right inferior frontal gyrus, presupplementary...
Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation some cases pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake typically fueled by contamination fears; fears choking, vomiting, or swallowing; and/or sensory issues, such as texture, taste, olfactory concerns. However, body image distortions may also be present. We investigate PANS disordered and compare it with that other disorders.We describe 29...
We employed event-related potentials to examine the feedback-related negativity (FRN), during a non-learning reward versus non-reward task. compared 10-12-year-old, 13-14-year-old, and 15-17-year-old youth (n = 91). Age effects included larger FRN for younger age groups, regardless of feedback type, decrease in peak latency feedback, across groups as linear trend. Males showed responses irrespective type longer rewarded feedback. Source modeling revealed reward/non-reward differences...
Background Severe, chronic irritability is receiving increased research attention, and the cardinal symptom of a new diagnostic category, disruptive mood dysregulation disorder (DMDD). Although data from epidemiological community samples suggest that childhood predicts unipolar depression anxiety in adulthood, whether these symptoms are stable cause ongoing clinical impairment unknown. The present study presents 4-year prospective longitudinal on sample children selected for severe...
Objectives: Previous studies have indicated abnormalities in response flexibility pediatric bipolar disorder (BD). Dysfunction may contribute to the pattern of behavioral and emotional dysregulation that is characteristic BD, since depressed manic patients respond inflexibly stimuli (i.e., anhedonia case depression or inappropriate positive affect mania). The present study was undertaken determine if neuronal responses differed between BD control subjects on a simple motor task. Methods: To...
Adolescence is a critical period of neurodevelopment for stress and appetitive processing, as well time increased vulnerability to engagement in risky behaviors. This study was conducted examine brain activation patterns during favorite-food-cue experiences relative neutral-relaxing condition adolescents. Functional magnetic resonance imaging employed using individualized script-driven guided imagery compare responses with such 43 Main effects gender were found, without significant...
Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a neurologist.Thirteen 15 (87%) had abnormalities detected PSG. Twelve evidence rapid eye movement (REM) motor disinhibition, as characterized excessive movement, laughing, hand stereotypies, moaning, or the...