A5027117126- Neurofibromatosis and Schwannoma Cases
- Obsessive-Compulsive Spectrum Disorders
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Sarcoma Diagnosis and Treatment
- Topic Modeling
- Bacterial Genetics and Biotechnology
- Neuroblastoma Research and Treatments
- Web Data Mining and Analysis
- Biochemical and Molecular Research
- Acute Ischemic Stroke Management
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Advanced Control Systems Optimization
- Autism Spectrum Disorder Research
- Escherichia coli research studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Histone Deacetylase Inhibitors Research
- Eating Disorders and Behaviors
- Advanced Text Analysis Techniques
- Peripheral Neuropathies and Disorders
- Academic integrity and plagiarism
- Clostridium difficile and Clostridium perfringens research
University of Minnesota
2012-2025
University of Minnesota Medical Center
2004-2025
Massachusetts General Hospital
2014-2025
Harvard University
2014-2025
Canon (United States)
2019-2024
University of Minnesota System
2024
Mayo Clinic in Florida
2023-2024
University at Buffalo, State University of New York
2019-2024
Canon (Japan)
2023
Twin Cities Orthopedics
2006-2022
Voice-controlled intelligent personal assistants, such as Cortana, Google Now, Siri and Alexa, are increasingly becoming a part of users' daily lives, especially on mobile devices. They introduce significant change in information access, not only by introducing voice control touch gestures but also enabling dialogues where the context is preserved. This raises need for evaluation their effectiveness assisting users with tasks. However, order to understand which type user interactions reflect...
To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results these inconsistent, likely as a consequence small sample sizes variable methodologies. Furthermore, data concerning heritability factors are limited. Item category-level YBOCS-CL items from 1224 OCD subjects were followed by in 52 OCD-affected...
Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation infection Streptococcus pyogenes. PANDAS may result from induced autoimmunity against brain antigens, although this remains unproven. Pilot work suggests that IgG antibodies children bind to cholinergic interneurons (CINs) in the striatum. CIN deficiency has been...
SPOR domains are approximately 70 amino acids long and occur in >1,500 proteins identified by sequencing of bacterial genomes. The the FtsN cell division from Escherichia coli Caulobacter crescentus have been shown to bind peptidoglycan. Besides FtsN, E. has three additional domain proteins--DamX, DedD, RlpA. We show here that all these localize septal ring coli. loss DamX or DedD either alone combination with mutations genes encoding other resulted a variety phenotypes, demonstrating...
We present a framework for constructing specific type of knowledge graph, concept map from textbooks. Using Wikipedia, we derive prerequisite relations among these concepts. A traditional approach extraction consists two sub-problems: key and relationship identification. Previous work the most part had considered sub-problems independently. propose that jointly optimizes investigates methods identify relationships. Experiments on maps are manually extracted in six educational areas (computer...
In neurofibromatosis type 1 (NF1) and in highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), constitutively active RAS-GTP increased MAPK signaling are important tumorigenesis. Dual specificity phosphatases (DUSPs) negative regulators of that dephosphorylate p38, JNK, ERK different settings. Although often acting as tumor suppressors, DUSPs may also act oncogenes, helping cells adapt to high levels signaling. We hypothesized inhibiting might be selectively toxic from...
Abstract Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin ( NF1 ). patients present with variety of clinical manifestations and are predisposed to cancer development. Many animal models have been developed, yet none display the spectrum seen translational impact these has limited. We describe minipig model that exhibits hallmarks NF1, including café au lait macules, neurofibromas, optic pathway glioma. Spontaneous loss heterozygosity observed this...
Article AbstractObjective: To examine in a sex-sensitive manner the frequencies, clinical correlates, and patterns of co-occurrence impulse-control disorders adolescent psychiatric inpatients. Method: 102 consecutive adolescents (54.9% females; mean age = 15.8 ± 1.4 years) admitted to an inpatient service for variety were screened from January through June 2006 using Minnesota Impulsive Disorders Interview. Subjects screening positive blindly evaluated with structured interviews. Results:...
Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation some cases pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake typically fueled by contamination fears; fears choking, vomiting, or swallowing; and/or sensory issues, such as texture, taste, olfactory concerns. However, body image distortions may also be present. We investigate PANS disordered and compare it with that other disorders.We describe 29...
INTRODUCTION: The current gold standard in prognostic stroke imaging is CT perfusion (CTP) imaging. This semi-quantitative modality approximates the infarct and penumbra regions within brain from parametric maps, aiding treatment decision making. While this gives a good indication of at-risk tissue during assessment, there are many microvascular phenomena which not successfully captured reported CTP imaging, but contribute significantly to dead volumes brain. METHODS: A 1x1x1 mm model was...
Introduction: SARS-CoV-2 (COVID-19) infection has been implicated in the onset of neuropsychiatric symptoms adults and children. While outcomes COVID-19 vaccination have tracked general pediatric population, little is known their impact on children with preexisting syndromes, including acute-onset syndrome (PANS) autoimmune disorders associated streptococcal infections (PANDAS). The aim this study to understand prevalence severity PANS/PANDAS following or PANS/PANDAS. Methods: We analyzed...
The use of CRISPR to knockdown or knockout genes is a powerful tool for understanding the specific role gene in disease development. However, it can cause many unanticipated changes transcriptome that are not detected by DNA amplification and Sanger sequencing target site. Various RNA-sequencing techniques be used identify these effectively gauge full impact knockout, thereby providing means selecting appropriate clones further experimentation. Background/Objectives: RNA-seq data from 4...
Clostridium difficile is a clinically important pathogen and the most common cause of hospital-acquired infectious diarrhea. Expression C. gene csfV, which encodes σ(V), an extracytoplasmic function σ factor, induced by lysozyme, damages peptidoglycan bacteria. Here we show that σ(V) required for lysozyme resistance in difficile. Using microarray analysis, identified genes whose expression dependent upon lysozyme. Although wild-type intrinsically highly deacetylated, have found exposure to...
Concept hierarchies have been useful tools for presenting and organizing knowledge. With the rapid growth in number of online knowledge resources, automatic concept hierarchy extraction is increasingly attractive. Here, we focus on from textbooks based Wikipedia. Given a book, extract important concepts each book chapter using Wikipedia as resource this construct that book. We define local global features capture both relatedness coherence embedded textbook. In order to evaluate proposed...
During growth in the environment, bacteria encounter stresses which can delay or inhibit their growth. To defend against these stresses, induce both resistance and repair mechanisms. Many regulate mechanisms using a group of alternative σ factors called extracytoplasmic function (ECF) factors. ECF represent largest most diverse family Here, we demonstrate that activation member ECF30 subfamily factors, σ(V) Bacillus subtilis, is controlled by proteolytic destruction anti-σ factor RsiV. We...
ABSTRACT Little is known about cell division in Clostridium difficile , a strict anaerobe that causes serious diarrheal diseases people whose normal intestinal microbiome has been perturbed by treatment with broad-spectrum antibiotics. Here we identify and characterize gene cluster encoding three proteins found only C. small number of closely related bacteria. These were named MldA, MldB, MldC, for m idcell l ocalizing d ivision proteins. MldA predicted to be membrane protein coiled-coil...
Angiographic parametric imaging (API), based on digital subtraction angiography (DSA), is a quantitative tool that may be used to extract contrast flow parameters related hemodynamic conditions in abnormal pathologies such as intracranial aneurysms (IAs).To investigate the feasibility of using deep neural networks (DNNs) and API predict IA occlusion pre- post-intervention DSAs.We analyzed DSA images IAs post-treatment dome corresponding main artery (un-normalized data). We implemented...
We introduce MedicalSum, a transformer-based sequence-to-sequence architecture for summarizing medical conversations by integrating domain knowledge from the Unified Medical Language System (UMLS). The novel augmentation is performed in three ways: (i) introducing guidance signal that consists of words input sequence, (ii) leveraging semantic type UMLS to create clinically meaningful embeddings, and (iii) making use weighted loss function provides stronger incentive model correctly predict...