A5001470616- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Breast Implant and Reconstruction
- Prostate Cancer Treatment and Research
- Polyomavirus and related diseases
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Surgical Treatments
- Effects of Radiation Exposure
- COVID-19 and healthcare impacts
- Advanced Radiotherapy Techniques
- Intraperitoneal and Appendiceal Malignancies
- Renal cell carcinoma treatment
- Gastrointestinal Tumor Research and Treatment
- Management of metastatic bone disease
Paris-Est Sup
2017-2025
Hôpitaux Universitaires Henri-Mondor
2016-2025
Université Paris-Est Créteil
2018-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Institut Curie
2017-2024
Institut Mondor de Recherche Biomédicale
2018-2023
Yale University
2018-2023
Inserm
2018-2023
Université Gustave Eiffel
2023
Centre Hospitalier Universitaire Henri-Mondor
2014-2018
Identification of nodal metastasis and tumor extranodal extension (ENE) is crucial for head neck cancer management, but currently only can be diagnosed via postoperative pathology. Pretreatment, radiographic identification ENE, in particular, has proven extremely difficult clinicians, would greatly influential guiding patient management. Here, we show that a deep learning convolutional neural network trained to identify ENE with excellent performance surpasses what human clinicians have...
Radiation-induced late fecal incontinence (LFI) is one of the most quality-of-life impairing symptoms in prostate cancer. We aimed to assess impact radiotherapy (RT) technique and dose-volume effects on LFI using a robust score. identified 409 patients who underwent curative intent standard fractionated radiation therapy, 190 them were finally included analyzed. The severity was assessed Jorge & Wexner With median follow-up 55 months (range 15-96) months, crude rate 11.5%. In multivariate...
Objectives: Recent DESTINY-Breast trials have demonstrated trastuzumab deruxtecan’s effectiveness in HER2-positive and HER2-low metastatic breast cancer. However, safety concerns remain regarding its combination with radiation therapy (RT). The purpose of this work is to assess the toxicity profile combining deruxtecan RT patients cancer address these concerns. Methods: We conducted a retrospective study which included treated at Institut Curie Paris between November 2020 January 2024....
The standard of care for locally advanced non-small-cell lung cancer (NSCLC) is either surgery combined with chemotherapy pre- or postoperatively concurrent and radiotherapy. However, older frail patients may not be candidates due to the high mortality risk are frequently referred radiotherapy alone, which better tolerated but carries a disease recurrence. Recently, immunotherapy immune checkpoint inhibitors (ICIs) induce response rate among positive programmed death ligand 1 (PD-L1)...
Oncocytic carcinoma of the thyroid is a rare disease, characterized by poor prognosis and low response rate to radioiodine therapy. Crizotinib specific anaplastic lymphoma kinase (ALK) inhibitor, which was initially developed in non-small cell lung cancer. Other solid tumors harboring translocation ALK have been described, such as renal carcinoma, thyroid, colorectal, ovarian cancers, spitzoid melanoma. The research rearrangements tumor promising therapeutic track, treatments need be...
The standard of care for metastatic disease is systemic therapy. A unique subset patients with limited defined as distant involvement five anatomic sites or less (oligometastases) have a better chance remission improved survival and may benefit from local treatments such surgery stereotactic body radiotherapy (SBRT). However, to prevent further spread disease, treatment chemotherapy, targeted therapy, hormonal therapy be required. Older (70 years old above) physiologically frail younger...
This study aimed to evaluate the outcomes of patients with head and neck squamous cell carcinoma (HNSCC) who underwent resection refused recommended adjuvant therapy.Locoregional recurrence-free survival (LRRFS) time progression (TTP) were assessed in HNSCC treated surgery declined some or all therapy (refusal group (RG)) compared those received (TG).With a median follow-up 23 months, 2-year LRRFS was significantly lower 17 from RG 152 TG: 23.1% vs. 69%, HR=0.30, 95% confidence incidence...
To evaluate loco regional control and describe the patterns of failure in women with breast cancer irradiated by a previously described post-mastectomy highly conformal electron beam radiotherapy technique.We included all PMERT for non-metastatic (BC) between 2007 2011 our department. All cases bilateral BC were excluded. patients who experienced recurrence have been studied. Mapping recurrences was also performed compared ESTRO RTOG Guidelines volume definition delineation guidelines.Among...
The aim of this retrospective study was to assess outcomes SABR for metachronous isolated lung oligometastases from HNSCC.
Genomic classifiers such as the Prostate Score (GPS) could help to personalize treatment for men with intermediate-risk prostate cancer (I-PCa). In this study, we aimed evaluate ability of GPS change therapeutic decision making in I-PCa. Only patients intermediate NCCN risk group Gleason score 3 + 4 were considered. The primary objective was assess impact on stratification: clinical and genomic versus stratification alone. We also analyzed predictive role locally advanced disease (≥pT3+)...
The standard of care for locally advanced head and neck cancer is concurrent chemoradiation or postoperative irradiation with without chemotherapy. Surgery may not be an option older patients (70 years old above) due to multiple co-morbidities frailty. Additionally, the chemotherapy cisplatin ideal those oto- nephrotoxicity. Though carboplatin a reasonable alternative in pre-existing hearing deficit renal dysfunction, its efficacy inferior cancer. In addition, frequently associated grade 3-4...
Radiation therapy (RT), a novel approach to boost the anticancer immune response, has been progressively evaluated in neoadjuvant setting breast cancer (BC).We aimed evaluate immunity-related indicators of response chemoradiation (NACRT) BC for better treatment personalization.We analyzed data first 42 patients included randomized phase 2 Neo-APBI-01 trial comparing standard chemotherapy (NACT) and NACRT regimen locally advanced triple-negative (TN) luminal B (LB) subtype BC....
Cutaneous skin carcinoma is a disease of older patients. The prevalence cutaneous squamous-cell (cSCC) increases with age. head and neck region frequent place occurrence due to exposure ultraviolet light. Surgical resection adjuvant radiotherapy frequently advocated for locally advanced decrease the risk loco-regional recurrence. However, cancer patients may not be candidates surgery frailty and/or increased complications. Radiotherapy usually unresectable Compared basal-cell carcinoma, cSCC...
Objective: Our study aimed to compare regional node coverage and doses the organ at risk (OAR) using conventional technique (CT) vs “AMAROS” (AT) intensity-modulated radiation therapy (IMRT) techniques in patients receiving nodal irradiation (RNI) for breast cancer (BC). Methods: We included 30 consecutive with BC who received RNI including axillary nodes. Two independent blinded dosimetric plans were generated all patients. For target volume coverage, we analyzed V95%, D95%, mean minimal...