A5049988882- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Complement system in diseases
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Effects of Radiation Exposure
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Advanced Drug Delivery Systems
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Digestive system and related health
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Macrophage Migration Inhibitory Factor
- Cancer Research and Treatments
- FOXO transcription factor regulation
Monash University
2020-2022
Australian Regenerative Medicine Institute
2020
University of California, Berkeley
1970-1978
Stanford University
1972-1973
Thymus-derived cells (T cells) that actively suppress production of IgG2a immunoglobulins carrying the Ig-1b allotype have been found in adult (SJL x BALB/c)F(1) mice exposed to anti-Ig-1b early life. The suppression is specific for Ig-1b. allelic product, Ig-1a, unaffected. Spleen, lymph node, bone marrow, or thymus from suppressed by syngeneic spleen normal F(1) mice. When a mixture and transferred into lethally irradiated BALB/c mice, there short burst after which levels recipient fall...
Cytotoxic antiserum to theta antigen reduces the capacity of mouse spleen cells generate direct and indirect plaque-forming sheep erythrocytes in vitro but does not affect cells, their precursors, or hemopoietic stem cells. The response treated with is restored by thymus incubated vivo erythrocytes.
Using anti-allotype sera and AKR anti thetaC3H sera, a requirement for two cell types has been demonstrated in the adoptive secondary response of mice to heterologous erythrocytes. The have designated B cells [precursors plaque-forming (PFC)] T (thymus-influenced cells, not providing precursors detectable PFC). vivo indirect PFC spleen from primed is markedly reduced by vitro treatment with mixture anti-theta serum guinea pig (Anti theta + GPS). This fully restored control levels thymus...
Both helper and suppressor activities for an in vitro IgG anti-hapten (Lac) response to Lac-HRBC were demonstrated the same population of carrier (HRBC)-primed spleen cells. The relative radiosensitivity activity permitted selective removal suppression demonstration help. appear be T cell-dependent antigen-specific. Dilution analysis showed that help are mediated by distinct populations
Abstract The anti-Lac B precursor cells from BALB/c (H-2)d mice which survive cytotoxic treatment with anti-Iak and complement will respond to Lac-KLH in culture, but require more KLH helper T than unselected cell populations or surviving anti-Ig killing. These findings are not explainable by the classical Poisson assumption of a constant target T-B ionteraction. We propose interaction theory variable Ia on surface. quantitatively predicts observed dose response relationships, implies that...
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, set key transcription factors (Egr1, Irf1, FosB) that drives molecular functional differences between young states. Overall, by dissecting the signature aged ISCs, our study enhance regenerative capacity
Mouse spleen cells were cultured for 5 days with or without HRBC. Cultured 'parked' in irradiated syngeneic recipients 3 weeks and then tested their immunologic reactivity vitro. We found that from of HRBC-sensitized (S) as well control unsensitized (U) possessed radiosensitive suppressor radioresistant helper activities. Suppressor activity was observed by the capacity unirradiated S U to inhibit vitro generation IgM IgG PFC primed vivo HRBC LacKLH. Helper shown restore responses primed,...
Abstract We have examined the cytotoxic activity of anti-Iak serum and complement on various immune functions BALB/c (H-2d) cells. Since action this antiserum H-2d cells defines specificity Ia.7, an I-C region product, we looked at selective expression antigen. mainly used in vitro anti-Lac2 response to study involved induction regulation antibody. The data presented here show that Ia.7 is present both IgM IgG precursor B lesser amounts plaque-forming also recognizes with less efficiency a...