A5006185110- Air Quality and Health Impacts
- Water Treatment and Disinfection
- Noise Effects and Management
- Electromagnetic Fields and Biological Effects
- Hormonal and reproductive studies
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Impact of Technology on Adolescents
- Chemical Analysis and Environmental Impact
- Air Quality Monitoring and Forecasting
- Stress Responses and Cortisol
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Digital Mental Health Interventions
- Wireless Body Area Networks
- Energy and Environment Impacts
- Inhalation and Respiratory Drug Delivery
- Human-Automation Interaction and Safety
- Pharmacological Effects and Assays
- Social Media in Health Education
- Listeria monocytogenes in Food Safety
- Birth, Development, and Health
- Fungal Plant Pathogen Control
- Gestational Diabetes Research and Management
- Toxic Organic Pollutants Impact
Imperial College London
2013-2024
National Institute for Health Research
2017-2024
Medical Research Council
2024
MRC Centre for Environment and Health
2018-2024
UK Health Security Agency
2024
NIHR Imperial Biomedical Research Centre
2022-2023
University of North Carolina at Chapel Hill
2014-2022
Bristol Hospital
2021
King's College London
2017-2019
Churchill Hospital
2015
This paper summarizes the epidemiological evidence for adverse health effects associated with disinfection by-products (DBPs) in drinking water and describes potential mechanism of action. There appears to be good a relationship between exposure DBPs, as measured by trihalomethanes (THMs), bladder cancer, but other cancers including colorectal cancer is inconclusive inconsistent. some an association specifically THMs, little gestational age/intrauterine growth retardation and, lesser extent,...
<h3>Abstract</h3> <h3>Objective</h3> To investigate the relation between exposure to both air and noise pollution from road traffic birth weight outcomes. <h3>Design</h3> Retrospective population based cohort study. <h3>Setting</h3> Greater London surrounding counties up M25 motorway (2317 km<sup>2</sup>), UK, 2006 2010. <h3>Participants</h3> 540 365 singleton term live births. <h3>Main outcome measures</h3> Term low (LBW), small for gestational age (SGA) at term, weight. <h3>Results</h3>...
Evidence for associations between ambient air pollution and preterm birth stillbirth is inconsistent. Road traffic produces both pollutants noise, but few studies have examined these co-exposures together none to date with all-cause or cause-specific stillbirths. To analyse the relationship long-term exposure noise at address level during pregnancy risk of stillbirth. The study population comprised 581,774 live still births in Greater London area, 2006-2010. Outcomes were (<37 completed...
Each new generation of mobile phone technology has triggered discussions about potential carcinogenicity from exposure to radiofrequency electromagnetic fields (RF-EMF). Available evidence been insufficient conclude long-term and heavy use, limited by differential recall selection bias, or crude assessment. The Cohort Study on Mobile Phones Health (COSMOS) was specifically designed overcome these shortcomings. We recruited participants in Denmark, Finland, the Netherlands, Sweden, UK...
There appears to be very good epidemiological evidence for a relationship between chlorination by-products, as measured by trihalomethanes (THMs), in drinking water and bladder cancer, but the other cancers, including colorectal cancer inconclusive inconsistent. some THMs, small gestational age (SGA)/intrauterine growth retardation (IUGR) preterm delivery, outcomes such low birth weight (LBW), stillbirth, congenital anomalies semen quality The overall aim of HIWATE study is investigate...
Large-scale prospective cohort studies are invaluable in epidemiology, but they increasingly difficult and costly to establish follow-up. More efficient methods for recruitment, data collection follow-up essential if such remain feasible with limited public research funds. Here, we discuss how these challenges were addressed the UK COSMOS study where fixed budget time frame necessitated new approaches consent recruitment between 2009-2012. Web-based e-consent should be considered large scale...
The Cohort Study of Mobile Phone Use and Health (COSMOS) has repeatedly collected self-reported operator-recorded data on mobile phone use. Assessing health effects using information is prone to measurement error, but operator were available prospectively for only part the study population did not cover past To optimize reduce bias, we evaluated different statistical approaches constructing exposure histories within COSMOS. We compared performance 4 regression calibration (RC) methods...
Given that many people typically spend the majority of their time at home, accurate measurement and modelling home environment is critical in estimating exposure to air pollution. This study investigates fate impact on human outdoor indoor pollutants London homes, using a combination sensor measurements, pollution estimated from CMAQ-urban model mass balance models. Averaged concentrations PM2.5, PM10 NO2 were 14.6, 24.7 14.2 μg m−3 while 14.4, 22.6 21.4 m−3, respectively. Mean infiltration...
Adolescents are susceptible to mental illness and have experienced substantial disruption owing the COVID-19 pandemic. The digital environment is increasingly important in context of a pandemic when in-person social connection restricted.
The role of surfactant proteins A and D (SP-A SP-D) in lung clearance translocation to secondary organs inhaled nanoparticles was investigated by exposing SP-A SP-D knockout (AKO DKO) wild type (WT) mice nose-only for 3 hours an aerosol 20 nm gold (AuNPs). Animals were euthanised at 0-, 1-, 7- 28-days post-exposure. Analysis inductively coupled plasma mass spectrometry (ICP-MS) the liver kidneys showed that extrapulmonary below limits detection. Imaging lungs laser ablation ICP-MS confirmed...
Evidence for a relationship between trihalomethane (THM) or haloacetic acid (HAA) exposure and adverse fetal growth is inconsistent. Disinfection by-products exist as complex mixtures in water supplies, but THMs HAAs have typically been examined separately.We investigated joint at the individual level to relation birth weight multi-ethnic Born Bradford cohort.Pregnant women reported their consumption activities via questionnaire. These data were combined with area-level THM HAA...
Some studies have reported associations between municipal waste incinerator (MWI) exposures and adverse birth outcomes but there are few of modern MWIs operating to current European Union (EU) Industrial Emissions Directive standards. Associations modelled ground-level particulate matter ≤10 μm in diameter (PM10) from MWI emissions (as a proxy for emissions) within 10 km each MWI, selected infant mortality were examined all 22 Great Britain 2003–10. We also investigated with proximity...
There is increasing evidence that air pollution and noise may have detrimental psychological impacts, but there are few studies evaluating adolescents, ground-level ozone exposure, multi-exposure models, or metrics beyond outdoor residential exposure. This study aimed to address these gaps.
Disinfection by-product (DBP) exposure during pregnancy may be related to reduced fetal growth, but the evidence is inconclusive and improved DBP assessment required. The authors conducted a nested study on subset (n=39) of pregnant women in Born Bradford cohort assess validity TCAA based tap water sampling self-reported water-use; water-use questionnaire validity; use one-time urinary biomarker. levels urine home supply were quantified, was measured via 7-day diary, at 28 weeks gestation....
Personal measurements of radiofrequency electromagnetic fields (RF-EMF) have been used in several studies to characterise personal exposure daily life, but such data are limitedly available for adolescents, and not yet the United Kingdom (UK). In this study, we aimed RF-EMF adolescents study association between rules applied at school home restrict wireless communication use, likely implemented reduce other effects mobile technology (e.g. distraction). We measured 16 common frequency bands...