A5071978853- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Pelvic and Acetabular Injuries
- Foot and Ankle Surgery
- Hip and Femur Fractures
- Medical Imaging and Analysis
- Tendon Structure and Treatment
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Elbow and Forearm Trauma Treatment
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- Orthopaedic implants and arthroplasty
- Artificial Intelligence in Healthcare and Education
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Shoulder and Clavicle Injuries
- Radiomics and Machine Learning in Medical Imaging
- Pregnancy-related medical research
- Knee injuries and reconstruction techniques
- Trauma and Emergency Care Studies
- Surgical Simulation and Training
- Human Pose and Action Recognition
Klinikum Ludwigshafen
2013-2025
Heidelberg University
2012-2024
Ludwigshafen University of Business and Society
2016-2022
University Hospital Heidelberg
2011-2021
Berufsgenossenschaftliche Unfallklinik Ludwigshafen
2013-2017
Hautklinik Heidelberg
2011
Mutation is a fundamental process in tumorigenesis. However, the degree to which rate of somatic mutation varies across human genome and mechanistic basis underlying this variation remain be fully elucidated. Here, we performed cross-cancer comparison 402 whole genomes comprising diverse set childhood adult tumors, including both solid hematopoietic malignancies. Surprisingly, found that inactive X chromosome many female cancer accumulates on average twice up four times as mutations per...
Background: Adequate surgical treatment of intra-articular calcaneal fractures is challenging. Current clinical evidence on the superiority either extended lateral approach (ELA) or sinus tarsi (STA) and their impact radiologic functional outcome remains inconclusive, studies are characterized by low case numbers short follow-up periods. We hypothesized that using STA would lead to fewer complications revisions, without impairing fracture reduction short- midterm outcome. Methods: This...
The aim of this study was to evaluate the intraoperative revision rate and reasons for following 3D imaging in management dislocated articular tibial plateau fractures based on a large patient sample. This retrospective cohort included all patients who underwent open reduction internal fixation due type B or C fracture according AO/OTA classification between August 2001 December 2017 using cone beam CT (3D imaging) analysis implant placement. findings scan were categorized regarding amount...
In acetabular fractures, the assessment of reduction and implant placement has limitations in conventional 2D intraoperative imaging. 3D imaging offers opportunity to acquire CT-like images thus improve results. However, clinical experience shows that even limitations, especially regarding artifacts when implants are placed. The purpose this study was assess difference between postoperative CT placement. Twenty consecutive cases fractures were selected with a complete set data. largest...
Acute unstable syndesmotic lesions are regularly treated with closed or open reduction and fixation either a positioning screw tight rope. Conventional fluoroscopy is limited to identify malreduction of the ankle mortise. The aim study was validate criteria intraoperative cone beam CT in injuries by analyzing clinical outcome.Acute were fixation, mortise evaluated CT. patients grouped postoperatively according radiological 3D images. unknown surgeons. Malreduction assumed if one more not...
The reconstruction of anatomical joint surfaces, limb alignment and rotational orientation are crucial in the treatment fractures terms preservation function range motion. To assess reduction implant position intra-operatively, mobile C-arms mandatory to immediately continuously control these parameters. Usually, devices operated by OR staff or radiology technicians assessed surgeon who is performing procedure. Moreover, due special objectives intra-operative setting, situation cannot be...
Abstract Background The aim of the study was to validate a software‐based planning method for Schoettle Point and evaluate precision time efficiency its live overlay on intraoperative X‐ray. Methods A compared with surgeons' manual in an inter‐ intrarater study. Subsequently, K‐wire placement performed without planning. used achieved were statistically compared. Results average deviation between surgeons (1.68 mm; 2.26 mm) greater than discrepancy (1.30 1.38 mm). In comparison, provided...
Different radiation-techniques in treating local staged prostate cancer differ their dose- distribution. Physical phantom measurements indicate that for 3D, less healthy tissue is exposed to a relatively higher dose compared SSIMRT. The purpose substantiate distribution lymphocytes in-vivo and discuss the possibility of comparing it physical model total body distribution.For each technique (3D SSIMRT), blood was taken from 20 patients before 10 min after first fraction radiotherapy. isolated...
In radiotherapy, in vivo measurement of dose distribution within patients' lymphocytes can be performed by detecting gamma-H2AX foci lymphocyte nuclei. This method help determining the whole-body dose. Options for risk estimations toxicities normal tissue and incidence secondary malignancy are still under debate. this investigation, helical tomotherapy (TOMO) is compared with step-and-shoot IMRT (SSIMRT) prostate gland measuring lymphocytes. prospective study, blood was taken from 20...
Abstract Introduction Distal radioulnar joint (DRUJ) instabilities are challenging and their optimal treatment is controversial. In special cases or when reconstruction of the stabilizing triangular fibrocartilage complex (TFCC) fails, K-wire transfixation can be performed. However, no consensus has been reached regarding rotational position forearm in which this should done. Therefore, it was investigated whether anatomical reduction would best achieved by neutral supination forearm....
Background: There has been an increasing number of fragility fractures the sacrum in recent decade. With rates up to 28%, complication after surgical treatment are still at unacceptably high level, and new strategies urgently needed. Therefore, purpose this study was evaluate potential 3D-navigated trans-sacral bar osteosynthesis sacrum. Methods: Retrospectively, from 2017 2023, all cases with confirmed patients > 65 years age that were surgically treated navigated included,...