A5074937483- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Biochemical and Molecular Research
- Pancreatic and Hepatic Oncology Research
- Amino Acid Enzymes and Metabolism
- Neuroblastoma Research and Treatments
- Chemical Reactions and Isotopes
Maastro Clinic
2021-2024
Maastricht University
2021-2024
University Medical Center
2021
Institut d'Investigació Biomédica de Bellvitge
2019
One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that oncofetal HMGA2 gene aberrantly reexpressed many tumor types together its antisense transcribed pseudogene RPSAP52. RPSAP52 abundantly present cytoplasm, where it interacts RNA binding protein IGF2BP2/IMP2, facilitating to mRNA targets, promoting their translation by mediating recruitment on polysomes enhancing...
Abstract Background Lung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung (NSCLC). Metabolic rewiring a hallmark that causes treatment resistance, lacks insights into serine/glycine pathway adaptations upon radiotherapy. Methods We analyzed radiotherapy responses using mass-spectrometry-based metabolomics in NSCLC patient’s plasma lines. Efficacy conversion inhibitor sertraline with was investigated by proliferation, clonogenic spheroid assays, vivo...
The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% glioblastoma cases, we observed frequent amplifications rare mutations the gene encoding enzyme PSPH, which catalyzes last step serine. This urged us to unveil relevance PSPH genetic alterations subsequent ser/gly metabolism deregulation pathogenesis glioblastoma. Primary cells overexpressing PSPHV116I showed an increased clonogenic capacity, cell...
Transcribed ultraconserved regions (T-UCRs) are noncoding RNAs derived from DNA sequences that entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T-UCRs as regulators of gene has been proposed, their functions remain largely unknown. Herein, we describe the epigenetic silencing uc.160+ T-UCR gliomas and mechanistically define novel RNA-RNA regulatory network which modulates biogenesis several members miR-376 cluster. This includes...