A5100372540- CAR-T cell therapy research
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Phagocytosis and Immune Regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Renal and related cancers
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Cardiac Ischemia and Reperfusion
- Advanced biosensing and bioanalysis techniques
Zhejiang University
2024
Imperial College London
2014
Nanyang Medical College
2010
Although CRISPR-mediated genome editing holds promise for cancer therapy, inadequate tumor targeting and potential off-target side effects hamper its outcomes. In this study, we present a strategy using cryo-shocked lung cells as CRISPR-Cas9 delivery system cyclin-dependent kinase 4 ( CDK4 ) gene editing, which initiates synthetic lethal in KRAS-mutant non–small cell (NSCLC). By rapidly liquid nitrogen shocking, effectively eliminate the pathogenicity of while preserving their structure...
Abstract The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in management solid tumors by limiting infiltration and inducing exhaustion transferred cells. Here, we developed a bacterial-based adjuvant approach that augments T-cell for treatment. Our study reveals intratumor injection E. coli MG1655 normalizes vasculatures reprograms tumor-associated macrophages into M1 phenotype produce abundant CCL5, together facilitating adoptively...