A5064614647- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Global Maternal and Child Health
- Mycobacterium research and diagnosis
- Chronic Disease Management Strategies
- Sex work and related issues
- Machine Learning in Healthcare
- Ethics in Clinical Research
- Mental Health and Patient Involvement
- Child Nutrition and Water Access
- Mental Health Treatment and Access
- Gender Diversity and Inequality
- Health Policy Implementation Science
- Gender, Security, and Conflict
- HIV/AIDS drug development and treatment
- Sports, Gender, and Society
- Immunodeficiency and Autoimmune Disorders
- Adventure Sports and Sensation Seeking
- Biosimilars and Bioanalytical Methods
Desmond Tutu HIV Foundation
2015-2025
Stellenbosch University
2008-2025
Western Cape Department of Health
2017
Inserm
2016
Université de Bordeaux
2016
Creative Commons
2016
Institut de Recherche pour le Développement
2016
Tygerberg Hospital
2008
<sec><title>BACKGROUND</title>TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk progression from infection to disease. However, implementation TPT for children is poor most high-burden settings. The long duration and pill burden 6-month once-daily isoniazid regimen (6H) pose significant barriers completion. We aimed understand children’s, caregivers’, healthcare providers’ experiences 12-week once-weekly rifapentine (3HP) using a...
To achieve UNAIDS 90:90:90 targets at population-level, knowledge of HIV status must be followed by timely linkage to care, initiation and maintenance antiretroviral therapy (ART) for all people living with (PLHIV). Interpreting quantitative patterns using qualitative data, we investigate time taken link care initiate ART amongst individuals aware their HIV-status in high HIV-prevalence urban communities the HPTN 071 (PopART) study, a community-randomised trial combination prevention...
Health workers in 21 government health facilities Zambia and South Africa linked spatial organisation of HIV services material items signifying HIV-status (for example, coloured client cards) to the risk People Living with (PLHIV) 'being seen' or identified by others. Demarcated services, distinctive flow associated-items were considered especially distinguishing. Strategies circumvent any resulting stigma mostly involved PLHIV avoiding and/or reducing contact visibility through alterations...
Abstract Background : Stigma and discrimination related to HIV key populations at high risk of have the potential impede implementation effective prevention treatment programmes scale. Studies measuring impact stigma on these are rare. We conducting an science study HIV-related in communities health settings within a large, pragmatic cluster-randomized trial universal testing intervention for Zambia South Africa will assess how affects, is affected by, this intervention. Methods/Design A...
Gauging community responses to the WHO 2015 recommendation provide antiretroviral treatment (ART) all people living with HIV (PLHIV) is critical. There limited qualitative evidence on acceptability of this Universal Test and Treat (UTT) strategy or understanding impact ART reducing transmission, promoted as Treatment Prevention (TasP). This article explores early UTT TasP in 21 urban communities South Africa Zambia 2013 before a randomized trial combination prevention-HPTN 071 (PopART). It...
Moxifloxacin (MFX) and linezolid (LZD) are key components of rifampicin-resistant TB treatment regimens. Currently, available dispersible tablet formulations both drugs have poor palatability in children. We evaluated children's preferences for more child-friendly from two generic manufacturers. This was a randomised, cross-sectional 'swish-and-spit' taste panel study at sites South Africa. Each manufacturer created three flavour-blend variants each drug. Healthy child volunteers 5-17 years...
Abstract Background In a cluster-randomised trial (CRT) of combination HIV prevention (HPTN 071 (PopART)) in 12 Zambian communities and nine South African communities, carried out from 2012 to 2018, the intervention arm A that offered treatment irrespective CD4 count did not have significant impact on population level incidence. Intervention B, where incidence was reduced by 30%, followed national guidelines mid (2016) changed starting according threshold 500 universal treatment. Using...
Current antiretroviral therapy (ART) adherence monitoring is premised on patients' self-reported behaviour (prone to recall error) and verified by blood viral load measurement (which can delay results). A newly developed Urine Tenofovir Rapid Assay (UTRA) assesses tenofovir in urine at point-of-care a novel tool test immediately respond levels of people living with HIV (PLHIV). We explored PLHIV health workers' initial perceptions about integrating the UTRA into routine medical care for...
This paper explores contextual heterogeneity within a community randomised trial HPTN 071 (Population Effects of Antiretroviral Treatment to Reduce HIV Transmission) carried out in 21 study communities (12 Zambian, 9 South African). The evaluates the impact combination prevention package (including household-based counselling and testing anti-retroviral treatment (ART) eligibility regardless CD4-count) on incidence. selection, matching randomisation relied key epidemiological demographic...
BACKGROUND: South Africa has one the highest TB and HIV burdens globally. preventive therapy (TPT) reduces risk of disease TB-related mortality in adults children living with is indicated for use TB-exposed HIV-negative individuals children. TPT implementation remains suboptimal. METHODS: We conducted a pragmatic review using multiple data sources, including informant interviews ( n = 134), semi-structured observations 93) patient folder reviews 31 health facilities purposively selected...
We describe and reflect on a rapid qualitative survey approach called “Broad Brush Survey” (BBS) used in six community-randomized trials (CRTs)/studies Zambia South Africa (2004–2018) to document, compare, classify, communicate community features systematically for public health multidisciplinary research ends. BBS is based set sequence of participatory methods fieldwork carried out prior CRT intervention and/or by social scientists generate profiles using four key indicators: physical...
To assess the impact of a combination HIV prevention intervention including universal testing and treatment (UTT) on stigma among people living with HIV, community members health workers not HIV.This study was nested in HPTN 071 (PopART) trial, three-arm cluster randomised trial conducted between 2013 2018 21 urban/peri-urban communities (12 Zambia nine South Africa).Using an adjusted two-stage cluster-level analysis, controlling for baseline imbalances, we compared multiple domains arms at...
Abstract Despite continued development of effective HIV treatment, expanded access to care and advances in prevention modalities, HIV‐related stigma persists. We examine how, the context a universal HIV‐testing treatment trial South Africa Zambia, increased availability services influenced conceptualisations HIV. Using qualitative data, we explore people’s stigma‐related experiences living ‘intervention’ ‘control’ study communities. conducted exploratory data analysis from cohort 150...
The global expansion of HIV testing, prevention and treatment services is necessary to achieve epidemic control promote individual population health benefits for people living with (PLHIV) in sub-Saharan Africa. Community-based workers (CHWs) could play a key role supporting implementation at scale. In the HPTN 071 (PopART) trial Zambia South Africa, cadre 737 study-specific CHWs, working closely government-employed CHW, were deployed deliver 'universal' door-to-door package, including an...
Abstract Background South Africa is reported to have the highest burden of HIV with an estimated 8.2 million people living (PLHIV) in 2021- despite adopting World Health Organisation (WHO) universal test and treat (UTT) recommendations 2016. As 2021, only 67% (5.5 million) all PLHIV were accessing antiretroviral therapy (ART), as per recorded clinic appointments attendance. Studies sub-Saharan show that low-income households experience multiple livelihood-related barriers either or adhering...
SETTING: Treatment tolerability among adolescents diagnosed with multidrug-resistant tuberculosis (MDR-TB) is underexplored. We present qualitative study data from participating in an observational cohort the Western Cape, South Africa. OBJECTIVE: To elicit adolescent experiences of MDR-TB diagnosis and treatment body-mapping activities discussions. DESIGN: Adolescents received routine toxicity audiology screenings clinicians. enrolled eight participants (age 10–16 years) to participate...
Introduction Broad Brush Surveys (BBS) are a rapid, qualitative assessment approach using four meta-indicators -physical features, social organization, networks and community narratives - to gauge how local context interfaces with service/intervention options, implementation uptake. Methods In 2021, responding rapid urbanization the accompanying need for water sanitation services, BBS was innovatively applied by scientists engineers assess infrastructure, both formal informal, in two African...
Aim: To determine the comprehensibility of preliminary paediatric food-based dietary guidelines (PFBDG) for infants younger than 6 months in South Africa.Methods: This qualitative study used focus group discussions held Western Cape to evaluate and understandability PFBDG. Groups were convened according area residence (rural, urban formal informal) ethnicity (white, coloured black) reflect population. Focus conducted participant’s home language, namely Afrikaans, English or Xhosa. The...
Background: Public health programming often frames HIV status disclosure as a means to negotiate condom- and abstinence-based prevention or involve intimate partners in care garner treatment adherence support. can be used ensure viral suppression prevent onward transmission, which provides strong evidence encourage disclosure. The ideological shift towards is expected facilitate Purpose: There lack of research on how the scale-up universal testing influences practices high burden settings....
HIV prevalence and incidence in South Africa remain high, making a part of everyday life. Community narratives on treatment prevention are important influence official unofficial health messaging community perceptions understandings HIV. We explore how contributors the columnist an agony aunt column position relative to choices made about love, partnership, sex over three years. analysed all columns series (Antie Mona) published between December 2012 November 2015. The is African,...
The South African Police Service (SAPS), like other policing institutions, is often associated with exaggerated and narrowly hegemonic ‘masculinity’ in which aggressiveness, dominance, fortitude, emotional composure, resilience an emphasis on physicality are pervasive ideals. officers perceived to embody these ideals, but few researchers have focused how this masculinity experienced by police officers. Semi-structured interviews situ observations were conducted at a large station the Western...
BACKGROUND: Multidrug-resistant TB (MDR-TB) treatment for children frequently includes unpalatable drugs with low overall acceptability. This can negatively impact and their caregivers´ experiences is an important contributor to poor adherence, potentially, outcomes. Children preferences MDR-TB are not well documented. We describe priorities inform future regimens.METHODS: conducted a cross-sectional qualitative study at hospital in South Africa using semi-structured interviews participatory...
Abstract: Public health researchers repeatedly represent women as a group vulnerable to ill health. This has been particularly true in the field of HIV research, where are disproportionately affected by terms disease burden and social effects epidemic. Although have focus many prevention treatment programs, structural barriers implementation these targeted programs persist. In this article we explore how high HIV-burden communities South Africa Zambia engage with concepts “woman” “HIV risk”....